Restoration of gut motility in Kit-deficient mice by bone marrow transplantation

Abstract

These results suggest that BM contains cells that may incorporate into ICC networks and improve dysmotility in W/W(v) mice. Thus, BM transplantation may become to a new therapeutic modality for gut dysmotilities due to ICC insufficiency.

Is This the Era of Interstitial Cells of Cajal Transplantation?

“…22 In that study, however, detailed functional stud- Transplantation successfully induced the BM-derived ICC clusters at the level of the myenteric plexus, consistent with two previous studies. 21,22 However, the range of ICC cluster distribution after BM transplantation was not concordant. Ishii et al 22 observed repopulation of ICC in the deep muscular plexus and submucosal plexus, as well as myenteric plexus following BM transplantation.…”

“…Furthermore, spatio-temporal mapping of smooth muscle contractile activity revealed that normal activity could not be induced after transplantation. These observations also contradict the results published by Ishii et al,22 which demonstrated increased gastric and intestinal transit.…”

“…21,22 However, the range of ICC cluster distribution after BM transplantation was not concordant. Ishii et al 22 observed repopulation of ICC in the deep muscular plexus and submucosal plexus, as well as myenteric plexus following BM transplantation. While difference in the method of BM transplantation, or the interval between transplantation and experiment may have contributed to this discrepancy, further investigation under various conditions will be necessary to fully elucidate these diverging observations.…”

“…20 In the wake of these observations, the intriguing possibility that BM-derived stem cells could differentiate into ICC has been raised. In this context, 2 recent studies have already generated positive results, 21,22 with 1 study even establishing evidence of improved motility. 22 In that study, however, detailed functional stud- Transplantation successfully induced the BM-derived ICC clusters at the level of the myenteric plexus, consistent with two previous studies.…”

“…In this context, 2 recent studies have already generated positive results, 21,22 with 1 study even establishing evidence of improved motility. 22 In that study, however, detailed functional stud- Transplantation successfully induced the BM-derived ICC clusters at the level of the myenteric plexus, consistent with two previous studies. 21,22 However, the range of ICC cluster distribution after BM transplantation was not concordant.…”