When designing complex organizational and technical systems, one of the main quality criteria is to meet the requirements for indicators characterizing the operational and technical level of the system. The task of substantiating these requirements has not been systematically approached. Requirements, most often, are presented empirically or using the apparatus of expert analysis. This is due to problems in the field of formalization of processes occurring in complex technical systems, difficulties arising in the construction of mathematical models and the development of criteria that allow optimizing information, technical, software, linguistic and other structures of ACS. The problem of substantiating the requirements should be solved using a systematic approach, and the whole set of properties, integral and partial indicators of the system should be taken into account. The study focuses on the approach to solving the problem of substantiating the requirements for reliability indicators of technical means of an organizational and technical system using the apparatus of continuous Markov processes. Time between failures and recovery time were used as reliability indicators. As a result, we found an analytical solution to the problem of substantiating the requirements for the reliability indicators of technical means and the characteristics of their performance, as well as the number of computer network workstations, necessary to meet the integral requirements for the ACS.