Restraint stress-induced immunosuppression by inhibiting leukocyte migration and Th1 cytokine expression during the intraperitoneal infection of Listeria monocytogenes

Zhang, Donglei; Kishihara, Kenji; Wang, Bing; Mizobe, Koji; Kubo, Chiharu; Nomoto, Kikuo

doi:10.1016/s0165-5728(98)00197-0

Cited by 65 publications

(32 citation statements)

References 52 publications

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“…It is well known that treatment with glucocorticoids increases vulnerability to infections. The serum glucocorticoid concentration is known to increase in response to various factors, including fasting (Millward et al 1983;Mitev et al 1993) and infections (Zhang et al 1998). In all the fasted groups, the serum corticosterone concentration increased due to the 72 h fasting process (Table 5), and returned to the pre-fasting level within 1 h after initiation of refeeding (results not shown).…”

Section: Effect Of Fasting On Corticosterone and Adrenocorticotrophicmentioning

confidence: 86%

Effect of timing of food deprivation on host resistance to fungal infection in mice

Oarada

Nikawa

N.*³

2002

British Journal of Nutrition

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Mice were deprived of food for a period of 72 h at varying times relative to the time of infection with Paracoccidioides brasiliensis. Host resistance was diminished profoundly when the period of food deprivation was from 48 h before to 24 h after infection (group B). When food deprivation was initiated immediately after infection (group C), host resistance was reduced less profoundly. When food deprivation was initiated at 24 and 48 h post-infection, reductions in host resistance were only moderate or not observed respectively. These results suggest that the earlier in the course of infection starvation occurs, the more profoundly host resistance is impaired. When food deprivation was initiated 72 h before infection, finishing at the time of infection (group A), the reduction in host resistance was considerably less profound compared with group B mice, suggesting that refeeding initiated immediately after infection is responsible for rapid restoration of the antifungal resistance in starved mice. Infection-induced responses of corticosterone and interferon-g were changed according to the timing of food deprivation. Group A mice, similar to non-fasted controls, showed an infection-induced increase in serum corticosterone concentration, while groups B and C did not. Group C mice showed a substantially greater infection-induced increase in serum interferon-g compared with the other fasted and non-fasted control groups.

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Section: Effect Of Fasting On Corticosterone and Adrenocorticotrophicmentioning

confidence: 86%

Effect of timing of food deprivation on host resistance to fungal infection in mice

Oarada

Nikawa

N.*³

2002

British Journal of Nutrition

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“…[31][32][33] Because the strong glucocorticoid response can suppress multiple components of the immune response 32,73 , it seemed plausible that stressor-induced suppression of the mucosal immune response led to the observed changes in microbiota community structure. However, RST did not induce changes in TNF-a, iNOS, or IL-6 message levels in the colonic tissue (data not shown).…”

Section: Discussionmentioning

confidence: 99%

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Galley

Yu²,

Kumar

et al. 2014

Gut Microbes

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The commensal microbiota of the human gastrointestinal tract live in a largely stable community structure, assisting in host physiological and immunological functions. Changes to this structure can be injurious to the health of the host, a concept termed dysbiosis. Psychological stress is a factor that has been implicated in causing dysbiosis, and studies performed by our lab have shown that restraint stress can indeed shift the cecal microbiota structure as well as increase the severity of a colonic infection caused by Citrobacter rodentium. However, this study, like many others, have focused on fecal contents when examining the effect of dysbiosis-causing stimuli (e.g. psychological stress) upon the microbiota. Since the mucosa-associated microbiota have unique properties and functions that can act upon the host, it is important to understand how stressor exposure might affect this niche of bacteria. To begin to understand whether chronic restraint stress changes the mucosa-associated and/or luminal microbiota mice underwent 7 16-hour cycles of restraint stress, and the microbiota of both colonic tissue and fecal contents were analyzed by sequencing using nextgen bacterial tag-encoded FLX amplicon technology (bTEFAP) pyrosequencing. Both control and stress groups had significantly different mucosa-associated and luminal microbiota communities, highlighting the importance of focusing gastrointestinal community structure analysis by microbial niche. Furthermore, restraint stress was able to disrupt both the mucosa-associated and luminally-associated colonic microbiota by shifting the relative abundances of multiple groups of bacteria. Among these changes, there was a significant reduction in the immunomodulatory commensal genus Lactobacillus associated with colonic mucosa. The relative abundance of Lactobacillus spp. was not affected in the lumen. These results indicate that stressor-exposure can have distinct effects upon the colonic microbiota situated at the mucosal epithelium in comparison to the luminal-associated microbiota.

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“…The probe cDNA for CIS3 and GAPDH has been described previously (17). For RT-PCR, primers for murine IL-1β, IL-6, TNF-α, and IL-10 were described previously (17,25) detected by standard RT-PCR methods using Standard GeneAmp RNA PCR kit (PE Biosystems, Foster City, California, USA) according to the manufacturer's instructions.…”

Section: Methodsmentioning

confidence: 99%

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

Shouda¹,

Yoshida²,

Hanada³

et al. 2001

J. Clin. Invest.

349

240

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Restraint stress-induced immunosuppression by inhibiting leukocyte migration and Th1 cytokine expression during the intraperitoneal infection of Listeria monocytogenes

Cited by 65 publications

References 52 publications

Effect of timing of food deprivation on host resistance to fungal infection in mice

Effect of timing of food deprivation on host resistance to fungal infection in mice

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis

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