Results from a peer-based digital systems navigation intervention to increase HIV prevention and care behaviors of young trans women in Rio de Janeiro, Brazil

Wilson, Erin C.; Jalil, Emilia Moreira; Jalil, Cristina Moreira; Castro, Cristiane R. V.; Ferreira, Ana Luiza N.; Martinez, Nilo F.; Moura, Isabele; Oliveira, Cleo; Bezerra, Daniel C.; Netto, Eduardo Carvalheira; Monteiro, Laylla; Veloso, Valdiléa G.; Grinsztejn, Beatriz

doi:10.29392/001c.28347

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…Table 1 outlines the characteristics of the eight studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35]. All studies proposed pilot and preparatory research during the initial 2 years, followed by a randomized controlled trial in the subsequent 3 years of the project.…”

Section: Resultsmentioning

confidence: 99%

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Tucker

Iwelunmor

Abrams

et al. 2021

Aids

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Objective: Many adolescents and young adults (AYA) have unmet HIV prevention needs. We describe the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC 3 H) consortium organization, transition milestones, and youth engagement strategies. The PATC 3 H consortium focuses on reducing HIV incidence and related health disparities among AYA.Design and Methods: Organizational data were obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and supplemented with a brief survey completed by study principal investigators. Transition from the initial phase (years 1 and 2) to the subsequent phase (years 3 and 5) was contingent on meeting prespecified milestones. We reviewed the structure and function of the research consortium, identified shared elements of transition milestones, and examined common youth engagement strategies. Results:The PATC 3 H consortium supports eight research studies through a milestone transition mechanism. The consortium includes AYA HIV research studies in seven

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Section: Resultsmentioning

confidence: 99%

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Tucker

Iwelunmor

Abrams

et al. 2021

Aids

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“… 43 Studies addressing barriers to PrEP use and continuation specifically among young MSM and TGW are currently ongoing in Rio de Janeiro, aiming to evaluate strategies tailored specifically for young MSM and young TGW to support PrEP use in these groups. 44 , 45 …”

Section: Discussionmentioning

confidence: 99%

Travestis, transgender women and young MSM are at high risk for PrEP early loss to follow-up in Rio de Janeiro, Brazil

Guevara

Coelho

Veloso

et al. 2023

The Brazilian Journal of Infectious Diseases

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“…Among young cis women in Africa, PrEP uptake was facilitated when offered as part of an integrated sexual reproductive health service [ 58 ]. Based on the findings of the formative phase [ 32 ], BeT intervention will be the first intervention tested to meet the needs of the transgender women population in LMICs and may be implemented in resource-constrained settings. We also expect stigma to be reduced over time as participants are engaged in a gender-affirming transgender-centered clinic where an antistigma campaign has been conducted.…”

Section: Discussionmentioning

confidence: 99%

“…The study had a formative phase, which comprised developing and implementing an antistigma campaign, and adaptation and pilot testing of the system navigation intervention [ 32 ]. The campaign content included information on basic gender definitions (sex, gender identity, gender expression, and sexual orientation), regulations linked to gender and sexual orientation minorities, the medical transition process, overview of mental health and hormone therapy among transgender people, transphobia and violence against transgender people, and HIV among transgender women ( Figure 1 ).…”

Section: Methodsmentioning

confidence: 99%

“…The BeT study pilot-assessed the intervention’s preliminary efficacy among 20 participants. Results from the pilot intervention demonstrated preliminary efficacy for improving HIV prevention and care behaviors among young transgender women, as all HIV-negative participants were engaged in PrEP and all but one participant living with HIV became virally suppressed [ 32 ]. After the pilot phase, the team refined the intervention, which focused on streamlining the adapted intervention manual to improve peer navigator and participant accessibility.…”

Section: Methodsmentioning

confidence: 99%

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A Peer-Led Digital Intervention to Reduce HIV Prevention and Care Disparities Among Young Brazilian Transgender Women (The BeT Study): Protocol for an Intervention Study

Jalil¹,

Wilson²,

Monteiro³

et al. 2023

JMIR Res Protoc

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Background The HIV epidemic continues to disproportionately burden marginalized populations despite the availability of effective preventive and therapeutic interventions. Transgender women are severely affected by HIV worldwide including in Brazil and other low- and middle-income countries, with evidence of increasing new infections among young people. There is an urgent need for youth-specific HIV prevention and care interventions for young transgender women in Brazil. Objective This study aims to (1) address stigma in the Brazilian public health system and (2) reduce barriers to HIV care and prevention with systems navigation among young transgender women aged 18-24 years in Rio de Janeiro, Brazil. Methods The Brilhar e Transcender (BeT) study is a status-neutral, peer-led, single-arm digital intervention study enrolling 150 young transgender women in Rio de Janeiro, Brazil. The intervention was pilot tested and refined using data from a formative phase. The BeT intervention takes place over 3 months, is delivered remotely via mobile phone and in person by peers, and comprises three components: (1) BeT sessions, (2) digital interactions, and (3) automated messages. Eligibility criteria include identifying as transgender women, being aged 18-24 years, speaking in Portuguese, and living in the Rio de Janeiro metropolitan area in Brazil. The primary outcomes are HIV incidence, pre-exposure prophylaxis uptake, linkage to HIV care, and viral suppression. Primary outcomes were assessed at baseline and quarterly for 12 months. Participants respond to interviewer-based surveys and receive tests for HIV and sexually transmitted infections. Results The study has been approved by the Brazilian and the US local institutional review boards in accordance with all applicable regulations. Study recruitment began in February 2022 and was completed in early July 2022. Plans are to complete the follow-up assessment of study participants on July 2023, analyze the study data, and disseminate intervention results by December 2023. Conclusions Interventions to engage a new generation of transgender women in HIV prevention and care are needed to curb the epidemic. The BeT study will evaluate a digital peer-led intervention for young transgender women in Brazil, which builds on ways young people engage in systems and uses peer-led support to empower transgender youth in self-care and health promotion. A promising evaluation of the BeT intervention may lead to the availability of this rapidly scalable status-neutral HIV intervention that can be translated throughout Brazil and other low- and middle-income countries for young transgender women at high risk of or living with HIV. Trial Registration ClinicalTrials.gov NCT05299645; https://clinicaltrials.gov/ct2/show/NCT05299645 International Registered Report Identifier (IRRID) DERR1-10.2196/44157

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Results from a peer-based digital systems navigation intervention to increase HIV prevention and care behaviors of young trans women in Rio de Janeiro, Brazil

Cited by 8 publications

References 32 publications

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Travestis, transgender women and young MSM are at high risk for PrEP early loss to follow-up in Rio de Janeiro, Brazil

A Peer-Led Digital Intervention to Reduce HIV Prevention and Care Disparities Among Young Brazilian Transgender Women (The BeT Study): Protocol for an Intervention Study

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