Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

Offenbacher, Steven; Beck, James D.; Moss, Kevin; Mendoza, Luisito; Paquette, David W.; Barrow, David A.; Couper, David J.; Stewart, Dawn; Falkner, Karen L.; Graham, Susan; Grossi, Sara G.; Gunsolley, John C.; Madden, Theresa E.; Maupomé, Gerardo; Trevisan, Maurizio; Dyke, Thomas E. Van; Genco, Robert J.

doi:10.1902/jop.2009.080007

Cited by 212 publications

(193 citation statements)

References 34 publications

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“…Nekoliko je autora istraživalo je li potrebna rigorozna preventivna i parodontološka njega kako bi se smanjio kardiovaskularni rizik (26), popravili nalazi biomarkera i ishodi CVD-a (27) te utječe li parodontološka terapija pozitivno na smanjenje razine serumskoga C-reaktivnog proteina i na poboljšanje funkcije endotela (27,28). Prema tome, pravodobna dijagnoza parodontitisa u populaciji te ciljana terapija i održavanje, trebali bi biti najvažniji u smanjenju opasnosti od CHD-a.…”

Section: Discussionunclassified

“…Several authors have examined the possibility that rigorous preventive and periodontal care is needed to reduce the cardiovascular risk (26) as well as to improve biomarkers and CVD outcomes (27) and that periodontal therapy has a positive effect in reducing serum C-reactive protein levels and improving the endothelial function (27,28). Therefore, the diagnosis of periodontitis in population and its treatment and maintenance should be of utmost importance in order to reduce the risk for CHD.…”

Section: Izjavamentioning

confidence: 99%

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Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Vražić¹,

Miovski

Strozzi

et al. 2015

Acta Stomatol Croat

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Section: Discussionunclassified

Section: Izjavamentioning

confidence: 99%

Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Vražić¹,

Miovski

Strozzi

et al. 2015

Acta Stomatol Croat

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“…The PAVE study showed that periodontal treatment decreases the serum concentration of CRP in the blood, and the effect was observed six months after treatment (odds ratio 0.26; 95% confidence interval: 0.09-0.72) [21,22]. In our study, all patients (complete and incomplete sanation) had professional hygienisation during a first visit to the dentist.…”

Section: Discussionmentioning

confidence: 57%

Incomplete oral sanation as a risk factor for elevated leucocytosis and postoperative infection

Konstanty-Kalandyk

Kalandyk-Konstanty

Kapelak³

et al. 2016

Kardiol Pol

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A b s t r a c tBackground: Patients after cardiac surgery are particularly at risk of infections. The oral cavity is a potential source of bacteria. Aim:To assess of influence of incomplete oral sanation on the probability of occurrence of infection in the postoperative period. Methods:The study subjects (n = 240) were patients undergoing cardiac surgery, with (n = 185) and without (n = 55) complete oral sanation. Complete oral sanation -patients had treated and eradicated all potential inflammatory foci in the oral cavity. Dental treatment: conservative dental treatment (70%), endodontic treatment (30%), and surgical dental treatment (85%), depending on treatment needs. Results:Patients with incomplete oral cavity sanation had more infections (7.27% vs. 1.62%, p = 0.062) in the postoperative period. The risk of infection was six times higher compared to the patients with complete sanation (p = 0.042), which correlated with higher level of leucocytosis in the early postoperative period (10.11 vs. 10.96 × 10 3 /µL, p = 0.059). Conclusions:Incomplete oral sanation is associated with higher levels of leucocytosis and greater risk of infection in the early postoperative period.

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“…Recently, clinical trials have shown a significant reduction of CPR levels and other inflammatory markers in serum after periodontal therapy [50]. Furthermore, a multi-centered randomized control study showed that periodontal therapy can reduce the CRP levels from high to moderate in non-obese periodontal disease patients [51]. Similar results confirmed by a randomized controlled trial that the levels of CRP reduced after periodontal therapy [52].…”

Section: Effect Of Periodontal Intervention On C-reactive Proteinmentioning

confidence: 72%

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

Chen¹,

Zhang²,

Xu³

et al. 2017

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Aims: Cardiovascular disease (CVD) and periodontitis are both chronic inflammatory disorders which are highly prevalent in populations. Bacteria involved in the periodontal disease have been found to be cardiovascular risk markers. Periodontal pathogens may contribute to the atheroma pathogenesis. Severe periodontitis is correlated with the prevalence of bacteraemia, and poor periodontal status is an important risk factor for CVD. However, the association is unclear. If the association is causal, the periodontal therapy will lead to an attenuation of the effects on CVD. The study aimed to study if the periodontal intervention therapy presented therapeutic effects on CVD. Methods: English language literature on periodontal intervention therapy on CVD is causal or not. The literature revealed 62 papers associated with this study to investigate the relationship between periodontitis and CVD. Results: The literature supported the idea that periodontal infections had been associated with CVD. Certain periodontal therapy is associated with bacteraemia, and the prevalence of bacteraemia may arise from periodontal therapy and poor oral hygiene practices. Periodontal therapy not only presented therapeutic effects by reducing cytokine activity and C-response protein (CRP), but also caused bacteraemia transitorily. Effective antibiotic prophylaxis pre-or post-periodontal therapy presented some beneficial effects on bacteraemia or CVD. Conclusion: Severe periodontitis causes systemic inflammation and endothelial dysfunction, and goes beyond the oral cavity. Periodontal intervention would contribute to the prevention of atherosclerosis, and antibiotic prophylaxis would be helpful to decrease bacteraemia and reduce the onset of CVD.

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Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

Abstract: Background-In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers.

Cited by 212 publications

References 34 publications

Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Periodontal Disease and its Association with Angiographically Verified Coronary Artery Disease

Incomplete oral sanation as a risk factor for elevated leucocytosis and postoperative infection

Is a Potential Therapeutic Strategy of Periodontal Intervention on Cardiovascular Disease, Yes or No?

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