Results of aggressive treatment of gastric sarcoma

Carson, William; Karakousis, Constantine P.; Douglass, Harold O.; Rao, Uma; Palmer, Michael L.

doi:10.1007/bf02303530

Cited by 37 publications

(27 citation statements)

References 9 publications

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“…Of 32 patients with gastric GIST, 41% presented with pain and 28% with GI bleeding. 37 Physical examination demonstrated a palpable mass in 12 of 32 patients. Thirty-nine small and large bowel GIST were identified at our institution.…”

Section: Managementmentioning

confidence: 99%

Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management

et al. 2000

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Gastrointestinal stromal tumors (GIST) are rare tumors of the gastrointestinal (GI) tract that arise from primitive mesenchymal cells. GISTs occur throughout the GI tract but are usually located in the stomach and small intestine. The majority of GISTs are immunohistochemically positive for c-kit protein (CD 117) and CD34. GISTs express a heterogeneous clinical course not easily predicted by standard pathological means. The most important prognostic factors are size > 5 cm, tumor necrosis, infiltration and metastasis to other sites, mitotic count > 1-5 per 10 high-powered fields, and most recently, mutation in the c-kit gene. Surgical resection remains the mainstay of treatment, as chemotherapy and radiation are ineffective. Long-term follow-up is imperative, as recurrence rates are high.

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Section: Managementmentioning

confidence: 99%

Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management

et al. 2000

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“…Finally, two studies reported the effect of surgery on metastatic disease. 50,55 The results (Tables 10 and 11) observed in these intervention studies in general did not promise patient benefit. Seven studies reported median survival (range 8-24 months).…”

Section: Results Reported In Studies Of Alternative Treatmentsmentioning

confidence: 91%

“…Of the nine trials that measured tumour response, only one patient (unlikely to have a true GIST) had a complete response. 55 In terms of tumour response, 13 patients out of a total of 258 cases (5%) achieved a partial response, while 64 (24%) were described as having stable disease. Adverse events were only described in eight trials.…”

Section: Results Reported In Studies Of Alternative Treatmentsmentioning

confidence: 99%

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Imatinib for the treatment of patients with unresectable and/or metastatic gastrointestinal stromal tumours: systematic review and economic evaluation

Wilson

Connock²,

Song³

et al. 2005

Health Technol Assess

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Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. Declared competing interests of authors: D Peake has been paid by Novartis to give one lecture on GIST and was sponsored to attend the Third International Symposium on GIST. Other than this, members of the review team at the University of Birmingham have no any pecuniary relationship with sponsors, specific or non-specific. J Raftery is Director of the NCCHTA but he was not involved in the editorial process for this report. HTA Published July 2005This report should be referenced as follows: NHS R&D HTA ProgrammeT he research findings from the NHS R&D Health Technology Assessment (HTA) Programme directly influence key decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC) who rely on HTA outputs to help raise standards of care. HTA findings also help to improve the quality of the service in the NHS indirectly in that they form a key component of the 'National Knowledge Service' that is being developed to improve the evidence of clinical practice throughout the NHS.The HTA Programme was set up in 1993. Its role is to ensure that high-quality research information on the costs, effectiveness and broader impact of health technolo...

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“…Even in adjuvant setting, the ef® cacy of radiotherapy and chemotherapy for sarcomas of gastrointestinal tract has not been well determined (10,11). The decrease in serum LDH levels immediately after the start of radiotherapy suggests that radiotherapy had a major effect in this recurrent tumor in our case.…”

mentioning

confidence: 74%

Long-Term Control for a Retroperitoneal Metastasis of Malignant Gastrointestinal Stromal Tumor after Chemoradiotherapy and Immunotherapy

Shioyama¹

2001

Acta Oncologica

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Results of aggressive treatment of gastric sarcoma

Cited by 37 publications

References 9 publications

Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management

Gastrointestinal Stromal Tumors: Current Diagnosis, Biologic Behavior, and Management

Imatinib for the treatment of patients with unresectable and/or metastatic gastrointestinal stromal tumours: systematic review and economic evaluation

Long-Term Control for a Retroperitoneal Metastasis of Malignant Gastrointestinal Stromal Tumor after Chemoradiotherapy and Immunotherapy

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