Resumption of Ovarian Function and Pregnancies in 358 Patients with Premature Ovarian Failure

Abstract

Intermittent ovarian activity in patients with POF is not a rare phenomenon. The predictive score described in this study may help us to identify POF patients most likely to recover intermittent ovarian function.

Executive Summary of the Stages of Reproductive Aging Workshop + 10: Addressing the Unfinished Agenda of Staging Reproductive Aging

“…The course of reproductive aging in women with POI/premature ovarian failure seems to be considerably more variable than that of women with normal reproductive aging. Not only are there several potential etiologies but also a substantial proportion of women have spontaneous resumption of menstrual function once the diagnosis has been confirmed, including ovulation and successful spontaneous pregnancy (76). Additional research is needed to better document the process of ovarian aging in these women and whether the course of ovarian aging differs by etiology of POI.…”

Fertility preservation in Turner syndrome

“…Regardless of whether conception is natural or medically assisted, increased rates of spontaneous abortion and fetal abnormality have been reported, as well as intrauterine growth restriction, low birth weight and prematurity (6,63). The high risk of miscarriage may be attributable to fetal genetic abnormalities or to a detrimental uterine environment (64)(65)(66).…”

Role of Ultrasound in the Assessment of Female Infertility

“…Nonpredictive factors included association with an autoimmune disease, anti mullerian hormone level, the presence of follicles on biopsy and genetic abnormalities. 55 As exhibited in this study, ultrasound is a superior tool not only for diagnosis, but also for predicting prognosis in women with POF.…”