Resveratrol ameliorates carbon tetrachloride-induced acute liver injury in mice

Fan, Guijuan; Tang, Jiang‐Jiang; Bhadauria, Monika; Nirala, Satendra Kumar; Dai, Fang; Zhou, Bo; Yang, Li; Liu, Zhong Li

doi:10.1016/j.etap.2009.05.013

Cited by 47 publications

(28 citation statements)

References 30 publications

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“…Also, Malathion may cause increase in serum AST, ALP, and ALT activities (Sharma et al, 2005). The disturbance in the transport function of the hepatocytes as a result of hepatic injury causes the leakage of enzymes from cells due to altered permeability of membrane (Fan et al, 2009). The increased levels of serum enzymes indicate an enhancement of permeability, damage or necrosis of hepatocytes.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat

Ismail¹

2013

J. Evol. Biol. Res.

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Malathion is a chemical pesticide, commonly used by Egyptian farmers; however, its contamination of water sources has become an important issue. It is suggested that the role of vitamin C in alteration of enzymes responsible for energy metabolism was induced by administration of Malathion. The effect of malathion and malathion with vitamin C on some enzymes in the rat were recorded in the present study. Significant increases in the level of hepatic enzymes (alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and gamma glutamyl transpeptidase) were recorded. Furthermore, renal markers such as urea, cholesterol and creatinine were increased in rats treated with malathion. Additionally, serum triglyceride was significantly decreased. No significant changes were observed in total protein, albumin and bilirubin in all treated groups as compared to the control. The present results showed that a significant (p < 0.001) decrease in glycolytic enzymes (hexokinase, pyruvatekinase, glucose phosphate isomerase and phosphofructokinase) were observed in treated groups, and lactate dehydrogenase enzyme activity also showed significant (p < 0.01) reduction. Coadministration of vitamin C to the groups restored all the parameters cited above to near-normal values. Therefore, the present investigation revealed that vitamin C appeared to be a promising agent for protection against malathion-induced toxicity.

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Section: Discussionmentioning

confidence: 99%

Protective effects of vitamin C against biochemical toxicity induced by malathion pesticides in male albino rat

Ismail¹

2013

J. Evol. Biol. Res.

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“…Moreover, glutathione depletion has been reported to increase sensitivity to As 2 O 3 -induced oxidative stress in cells [15]. Resveratrol has been shown to preserve antioxidant defense by preventing depletion of GSH [10,16]. In this study, resveratrol attenuated As 2 O 3 -induced oxidative stress, and this might be mediated (at least in part) by preserving levels of antioxidant enzymes and glutathione in tissues.…”

Section: Discussionmentioning

confidence: 62%

Resveratrol Ameliorates the Oxidative Damage Induced by Arsenic Trioxide in the Feline Lung

Cheng

Xue

Yao

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. The objective of this study was to evaluate the possible protection of resveratrol against lung injury induced by arsenic trioxide (As 2 O 3 ). Twenty-four healthy Chinese Dragon Li cats of either sex were randomly divided into four groups: control (1 ml/kg physiological saline), As 2 O 3 (1 mg/kg), resveratrol (3 mg/kg) and resveratrol (3 mg/kg) + As 2 O 3 (1 mg/kg). The resveratrol + As 2 O 3 -treated group was given resveratrol 1 hr before As 2 O 3 (1 mg/kg) administration. We found that pretreatment with resveratrol in a clinically comparable dose regimen can reversed the changes in morphological and biochemical parameters induced by As 2 O 3 in the lung. Resveratrol treatment also upregulated the activities of antioxidant enzymes and attenuated As 2 O 3 -induced increases in reactive oxygen species, 8-hydroxydeoxyguanosine and malondialdehyde production in the lung. In addition, resveratrol attenuated the As 2 O 3 -induced reduction in the ratio of reduced glutathione to oxidized glutathione, the content of total glutathione and lung arsenic burden. These findings indicated that resveratrol can provide significant protection against As 2 O 3 -induced oxidative damage.

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“…This result was confirmed by the report of Sharma et al (2005) who revealed a significant increase in AST, ALT, and ALP activities in pesticide-treated rats that may be due to increase in the secretory activities of the hepatocyte cells (Abdulaziz & Hristev, 1996;Yousef et al, 1999). The disturbance in the transport function and membrane permeability of the hepatocytes as a result of pesticide-induced hepatic injury results in the leakage of AST, ALT, and ALP from cells into the blood (Fan et al, 2009;Murussi et al, 2016).…”

Section: Discussionmentioning

confidence: 99%