Resveratrol ameliorates spermatogenesis by increasing protamine 1, 2 and HSPA2 expression in experimental varicocele rat model

Baazm, Maryam; Babaei, Rasool; Fathi, Amene Nikgoftar; Karami, Hadi; Bayat, Mohammad

doi:10.1016/j.androl.2023.100370

Cited by 1 publication

(1 citation statement)

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“…Animal models have proven to be valuable in the study of the male transcriptome. One study used a varicocele model to evaluate the effect of resveratrol, a naturally occurring polyphenol, and discovered decreased protein expression of protamine I/II and HSPA2 [90]. These results indirectly suggest that the downregulation of these proteins contributes to the pathogenesis of male-factor infertility.…”

Section: Transcriptomementioning

confidence: 99%

The Evolving Landscape of Male Varicocele Pathophysiology in the Era of Multi-Omics: A Narrative Review of the Current Literature

Munoz-Lopez,

Wong,

Lewis

et al. 2024

Biology

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Male-factor infertility is implicated in over half of the millions of cases of infertility worldwide, and varicoceles are the most common correctable cause of male-factor infertility. The pathophysiologic mechanism for varicoceles is complex and next-generation technologies offer promising insights into the molecular underpinnings of this condition. In this narrative review, we highlight historical and contemporary paradigms associated with varicoceles, with an emphasis on the biological underpinnings of this disease. Specifically, we review the literature describing the underlying causes of varicoceles, discuss the molecular and cellular mechanisms causing pathological changes in some (but not all) men, and highlight key articles regarding the next-generation analyses (e.g., transcriptome, epigenome, proteome, and microbiome) being applied to better understand the condition and its treatment. These data demonstrate an ongoing evolution of the knowledge of varicoceles and the potential for improved personalized care in the future for men with this condition.

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Section: Transcriptomementioning

confidence: 99%