Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Gál, Roland; Halmosi, Róbert; Gallyas, Ferenc; Tschida, Michael; Mutirangura, Pornthira; Tóth, Kálmán; Alexy, Tamás; Czopf, László

doi:10.3390/biomedicines11112888

Cited by 11 publications

(2 citation statements)

References 368 publications

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“…Since the modern lifestyle has led to an exponential increase in obesity, diabetes, dyslipidemia, and metabolic syndrome, as well as CVD and cancer, being among the leading causes of death worldwide, a change in eating habits and the consumption of healthier products can help prevent and even treat these diseases [52,53]. Due to the numerous health benefits of yacon and the lack of a review showing the effects of yacon flour, this work aims to systematically review the effects of yacon root flour on metabolic parameters related to metabolic syndrome.…”

Section: Bioactive Compound Biological Effects Referencesmentioning

confidence: 99%

Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review

Silva,

Bragante,

Junior

et al. 2024

Pharmaceuticals

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Smallanthus sonchifolius, popularly known as yacon, is a member of the Asteraceae family. Due to its medicinal and edible value, yacon is consumed by different populations. Yacon is unique due to its high fructo-oligosaccharide and inulin content, as well as flavonoids, sesquiterpene lactones, and phenolic acids. Roots can be used to produce flour, which is less perishable and can be applied in various industrial products. This systematic review focuses on the effects of yacon flour on metabolic parameters. PubMed, Cochrane, Embase, Science Direct, Scopus, Web of Science, and Google Scholar databases were consulted, and PRISMA guidelines were followed in the selection of the studies. In total, 526 articles were found in the databases, and of these, only 28 full texts were eligible for inclusion. After applying the inclusion and exclusion criteria, seven studies were finally included. The results showed that the use of yacon flour can reduce glycemia, HbA1c, advanced glycation ends, plasma lipids, body fat mass, body weight, and waist circumference and improve intestinal microbiota and the antioxidant status. Further exploration of the effects of yacon flour is warranted, and additional clinical trials are necessary to determine the optimal daily consumption levels required to assist in improving metabolic parameters.

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Section: Bioactive Compound Biological Effects Referencesmentioning

confidence: 99%

Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review

Silva,

Bragante,

Junior

et al. 2024

Pharmaceuticals

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show abstract

“…If looking at selected prominent polyphenols, whole review articles summarize their ability to bind to multiple biological targets, however, rarely is the underlying lack of selectivity highlighted. Recent examples from the literature include resveratrol, 58 EGCG, 59 or chlorogenic acids. 60 For the latter phenomenon, we observed in most polyphenol enzyme assays that the experimental Hill coefficient was larger than one.…”

Section: ■ Chemical Reactivity In Human Metabolismmentioning

confidence: 99%

Children of Nature: Thoughts on Targeted and Untargeted Analytical Approaches to Decipher Polyphenol Reactivity in Food Processing and Metabolism

Kuhnert

2024

J. Agric. Food Chem.

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Following 25 years of polyphenol research in our laboratory, the astonishing chemical and metabolic reactivity of polyphenols resulting in considerable chemical diversity has emerged as the most remarkable attribute of this class of natural products. To illustrate this concept, we will present selected data from black tea and coffee chemistry. In black tea chemistry, enzymatic fermentation converts six catechin derivatives into an estimated 30 000 different polyphenolic compounds via a process we have termed the oxidative cascade process. In coffee roasting, around 45 chlorogenic acids are converted into an estimated 250 novel derivatives following a series of diverse chemical transformations. Following ingestion by humans, these dietary polyphenols, whether genuine secondary metabolites or food processing products, encounter the microorganisms of the gut microbiota, converting them into a myriad of novel structures. In the case of coffee, only two out of 250 chlorogenic acids are absorbed intact, with most others being subject to gut microbial metabolism. Modern mass spectrometry (MS) has been key in unravelling the true complexity of polyphenols subjected to food processing and metabolism. We will accompany this assay with a short overview on analytical strategies developed, including ultrahigh-resolution MS, tandem MS, multivariate statistics, and molecular networking that allow an insight into the fascinating chemical processes surrounding dietary polyphenols. Finally, experimental results studying biological activity of polyphenols will be presented and discussed, highlighting a general promiscuity of this class of compounds associated with nonselective protein binding leading to loss of enzymatic function, another noteworthy general property of many dietary polyphenols frequently overlooked.

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Certainty and uncertainty in the biological activities of resveratrol

Drago,

Ciprandi,

Brindisi

et al. 2024

Food Frontiers

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Resveratrol is a nonflavonoid polyphenolic compound with a chemical structure consisting of two aromatic rings linked by a methylene bridge. It exists in two primary isomers and has a broad range of desirable biological activities, including antioxidant, anti‐inflammatory, antidiabetic, cardioprotective, and antitumor activities. Some antioxidant properties of resveratrol are known with certainty, such as its potential to positively impact cardiovascular health, inflammation, and the metabolism. On the other hand, many uncertainties and controversies plague its efficacy, including issues related to its bioavailability, dosing, human clinical trial results, interactions with other food components and drugs, and individual variability. In brief, although promising results have been observed in in vitro and in vivo studies, the translation of these findings to human health remains uncertain. Many human clinical trials on resveratrol are ongoing or have proven inconclusive, making it challenging to definitively determine its efficacy for specific health conditions and its dose and duration of treatment. Resveratrol may interact with medications and have varying effects on individuals. In conclusion, it is essential to approach resveratrol with a balanced perspective, consulting with healthcare professionals, and considering the evolving scientific evidence when making decisions regarding its clinical use.

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Resveratrol and beyond: The Effect of Natural Polyphenols on the Cardiovascular System: A Narrative Review

Cited by 11 publications

References 368 publications

Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review

Effects of Smallanthus sonchifolius Flour on Metabolic Parameters: A Systematic Review

Children of Nature: Thoughts on Targeted and Untargeted Analytical Approaches to Decipher Polyphenol Reactivity in Food Processing and Metabolism

Certainty and uncertainty in the biological activities of resveratrol

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