Resveratrol as an active ingredient for cosmetic and dermatological applications: a review

Abstract

Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties. Its popularity in cosmetology and dermatology is primarily associated with proven ability to penetrate the skin barrier and antiaging activity. It has been shown that formulations with resveratrol can stimulate the proliferation of fibroblasts and contributing to the increase in the concentration of collagen III. Resveratrol has an affinity for the estrogen protein receptors (both ERα and ERβ), thereby contributing to the stimulation of collagen types I and II production. Moreover, resveratrol also has the antioxidant properties, thus can protect cells against oxidative damage associated with the effects of free radicals and UV radiation on the skin by reducing the expression of AP-1 and NF-kB factors and it slows down the process of photoaging of the skin. This study reviews literature on the skin care properties of resveratrol and its dermal bioavailability, metabolism, and dermal safety of application.

Novel Nanocarriers for Targeted Topical Skin Delivery of the Antioxidant Resveratrol

“…There is good evidence for RSV supporting the heart function, protecting against cardiovascular diseases [3], neuro-disorders [4,5], diabetes [6], and cancer [7], due to its antioxidant and anti-inflammatory effects. Of particular relevance to this article, RSV has demonstrated a potential for antiaging effects and for protecting against UV damage in the skin due to its antioxidant and collagen stimulating activity [8,9].…”

In Vivo Antimicrobial and Wound-Healing Activity of Resveratrol, Dihydroquercetin, and Dihydromyricetin against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans

“…Plant-derived stilbenoids, especially Resveratrol and its derivatives, have become broadly known for their positive effects on a wide range of medical disorders reported in many published studies [2,3]. First, Resveratrol and Dihydroquercetin were isolated from grape juice and peanut and coniferous tree bark extracts [4] as agents responsible for the response to a fungus Botrytis cinereae infection in plants.…”

Resveratrol: a review of plant sources, synthesis, stability, modification and food application

“…At present, resveratrol has attracted increasing attention from the food community due to its lower cost and side effects . The resveratrol synthesized or extracted from plants had various bioactive effects and had preventive effects on illnesses such as cancers, cardiovascular disease, neurodegenerative diseases, and inflammation . Different oligomers of resveratrol were proven to exhibit a wide range of bioactivity, such as antibacterial, anti‐fungal, and antiviral effects .…”