Resveratrol Attenuates Learning, Memory, and Social Interaction Impairments in Rats Exposed to Arsenic

Abstract

Arsenic (As) toxicity has deleterious effects on human health causing disorder in the brain. The aim of this study was to investigate the possible neuroprotective effect of resveratrol (RSV) on arsenic-induced neurotoxicity in rats. Neurotoxicity in rats was developed by treating As 10 mg/kg/day for 21 days orally. Animals were put into seven groups: control, vehicle, As, As+RSV10, As+RSV20 mg/kg, RSV10, and RSV20 mg/kg. Behavioral assessments such as the social interaction test, novel object recognition test, elevated plus maze, open field, the Morris water maze, in addition to assessment of biomarkers such as ferric reducing ability of plasma assay, glutathione assay, and malondialdehyde assay, were used to evaluate the effects of RSV on cognitive impairment and molecular changes induced by As. The results showed that cognitive performance impaired in As rats. RSV20 mg/kg significantly could ameliorate behavioral changes like spatial learning in days 3 and 4 ( p < 0.05 ), recognition learning and memory ( p < 0.01 ), disabilities in motor coordination and stress ( p < 0.05 ), increased anxiety ( p < 0.05 ), and social interaction deficit (sociability ( p < 0.001 ) and social memory ( p < 0.05 )). RSV20 mg/kg also attenuated molecular modifications like decreased antioxidant power ( p < 0.001 ), reduced glutathione content ( p < 0.05 ), and increased malondialdehyde level ( p < 0.05 ) induced by As. In addition to oxidative stress assessments, RSV10 mg/kg could significantly increase FRAP ( p < 0.01 ) and GSH ( p < 0.05 ); however, MDA was not significantly increased. Our current behavioral findings suggest that RSV has neuroprotective effects against AS toxicity.

Chronic resveratrol administration reduces oxidative stress and brain cell loss and improves memory of recognition in old rats

“…On the other hand, the animals with RSVL registered locomotor improvements in the habituation stage compared to the control group. By showing a greater speed and a greater distance traveled in the experimentation box, this supports the theory that chronic RSVL treatment promotes neurophysiological changes that benefit motor behavior as well as short-and long-term memory (Taheri Zadeh et al, 2021).…”

“…Other reports refer that RSVL improves vascular functions, activates sirtuins (Moraes et al., 2020), and induces the synthesis of neurotrophic factors such as brain‐derived neurotrophic factor (Tang et al., 2020). Taken together, all these events contribute to the improvement in motor and memory function, which is severely affected in aging (Monserrat Hernández‐Hernández et al., 2016; Taheri Zadeh et al., 2021).…”

Early Intervention of Elateriospermum tapos Yoghurt in Obese Dams Mitigates Intergenerational Cognitive Deficits and Thigmotactic Behaviour in Male Offspring via the Modulation of Metabolic Profile

“…Increased levels of antioxidants (FRAP and GSH) could neutralise free radicals and prevent inflammatory responses [ 70 ] that are released by an excessive level of adipose tissue in obesity. Thus, increased levels of GSH and FRAP in the hypothalamus may reverse memory decline and ease anxiety-like behaviour [ 71 ]. This is because GSH acts as a protective shield for neurons from stress disturbance [ 72 ], while FRAP prevents memory deficits by reversing the deprivation of neurotransmitters [ 73 ].…”

Therapeutic potential of stilbenes in neuropsychiatric and neurological disorders: A comprehensive review of preclinical and clinical evidence

“…Considering the high number of people worldwide consuming water contaminated with arsenic as well as its neurotoxic properties, scientists decided to utilize arsenic to induce CNS dysfunctions in rodents and investigate whether supplementation with resveratrol could reverse the observed changes (Mehta et al, 2021; Taheri Zadeh et al, 2021). Arsenic administered for prolonged periods caused cognitive impairments and anxiety‐like behaviors in animals.…”

“…utilize arsenic to induce CNS dysfunctions in rodents and investigate whether supplementation with resveratrol could reverse the observed changes(Mehta et al, 2021;Taheri Zadeh et al, 2021). Arsenic administered for prolonged periods caused cognitive impairments and anxiety-like behaviors in animals.Mehta et al …”