Resveratrol Improves the Digestive Ability and the Intestinal Health of Siberian Sturgeon

Abstract

The lack of detailed information on nutritional requirement results in limited feeding in Siberian sturgeon. In this study, resveratrol, a versatile natural extract, was supplemented in the daily diet, and the digestive ability and microbiome were evaluated in the duodena and valvular intestines of Siberian sturgeon. The results showed that resveratrol increased the activity of pepsin, α-amylase, and lipase, which was positively associated with an increase in the digestive ability, but it did not influence the final body weight. Resveratrol improved the digestive ability probably by distinctly enhancing intestinal villus height. Microbiome analysis revealed that resveratrol changed the abundance and composition of the microbial community in the intestine, principally in the duodenum. Random forests analysis found that resveratrol significantly downregulated the abundance of potential pathogens (Citrobacter freundii, Vibrio rumoiensis, and Brucella melitensis), suggesting that resveratrol may also improve intestinal health. In summary, our study revealed that resveratrol improved digestive ability and intestinal health, which can contribute to the development of functional feed in Siberian sturgeon.

Resveratrol ameliorates ulcerative colitis by upregulating Nrf2/HO‑1 pathway activity: Integrating animal experiments and network pharmacology

“…OB ≥30% is considered 'drug-like'. Although the OB of Res is only 19.07%, there is growing evidence of the therapeutic potential of Res for intestinal health (58). But the relatively low OB and rapid metabolism of Res may limit its use in humans (59).…”

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

“…Environmental stresses (temperature, ammonia nitrogen, toxicant, etc) negatively impact the sh's metabolic balance, and reactive oxygen species and in ammation levels, ultimately affecting the yield and quality and even leading to mortality [5][6][7][8][9][10]. To mitigate the adverse effects and risks, several studies have suggested the supplementation of dietary additives, such as plant and animal extracts, bene cial probiotics, microalgae, and other substances [11][12][13][14][15][16][17].…”

“…Consequently, it has been utilized as an aquafeed additive to enhance the quality and economic value of aquatic products. In certain studies, resveratrol bene ts to the gut health of Siberian sturgeon by improving the structure of intestinal villi and the abundance and composition of microbial communities [14]. Additionally, it has been found to ameliorate the effects of a high-fat diet on hepatic antioxidant, in ammation, and lipid metabolism in carp (Cyprinus carpio) [22].…”

“…To understand the potential effects of resveratrol on Siberian sturgeon, daily diet supplied with 0.32 mg/kg resveratrol was determined based on previous study [14]. The aim of this study was to distinguish the potential effects of resveratrol and, thus, provide a guidance for the use of 0.32mg/kg resveratrol on the culture of Siberian sturgeon(Fig.…”

“…Resveratrol (3,4,5-trihydroxy-trans-stilbene) is a type of dietary polyphenols commonly found in peanuts, mulberry fruits, tiger nuts, grapes, and red wine [18]. Resveratrol has also shown potential in improving sh immunity, preventing stress-related issues, and reducing economic losses caused by diseases or stresses [14,[19][20][21][22][23]. Consequently, it has been utilized as an aquafeed additive to enhance the quality and economic value of aquatic products.…”