RESVERATROL INCLUSION COMPLEX WITH Β-Cyclodextrin (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

Nishihira, Vivian Shinobu Kishimoto; Mezzomo, Nathana J.; Baldissera, Matheus D.; Vaucher, Rodrigo A; Pinto, Cláudia Grigolo; Pohl, Ariane Ribas; Gomes, Patrícia; Rodrigues, Luiz Fernando; Frizzo, Clarissa P.; Bender, Caroline R.; Fantinel, Leonardo; Fernandes, Liana S; Giongo, Janice Luehring; Raffin, Renata Platcheck; Rech, Virgínia Cielo

doi:10.22159/ijpps.2017v9i1.15399

Cited by 2 publications

(1 citation statement)

References 30 publications

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“…The types of interactions formed, however, depend on the host cavity size, with α-CD, the narrowest of native cyclodextrins, being reported as a good solubilizer for RSV in aqueous media [ 15 , 16 ] but as unable to form authentic inclusion complexes with this guest in the solid-state [ 17 ]. β-CD has a less pronounced solubility enhancement effect on RSV [ 15 , 16 ], but, owing to its larger cavity, it forms with this guest a co-amorphous solid that can be used as a safe oral delivery system (no hematologic alterations were observed in a mouse model at a dose of 1 mg/kg of the compound) [ 18 ]. γ-CD, having the largest cavity size among the three native CDs, can fully accommodate RSV inside it to form authentic inclusion complexes.…”

Section: Introductionmentioning

confidence: 99%

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Silva

Monteiro

Resende

et al. 2020

Foods

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Microencapsulated resveratrol (RSV) is a pertinent ingredient in functional foods to be used in the prevention and management of cardiovascular diseases. Gamma-cyclodextrin (γ-CD) was evaluated for its RSV inclusion ability. Inclusion procedures comprised mixing equal concentration of an aqueous solution of γ-CD with an ethanol solution of RSV and freeze-drying to obtain a solid material. Solid-state characterization by vibrational spectroscopy, thermogravimetry, and powder X-ray diffraction (PXRD) confirmed the formation of the γ-CD·RSV complex in a ratio of 1:1. PXRD suggested that cyclodextrin molecules in the complex are stacked in infinite channels holding the RSV inside, with a wide inter-channel space where 14 water molecules are retained. Fresh lemon juices supplemented with 0.625 mg/mL of RSV in its free (RSV-juice) or complexed (γ-CD·RSV-juice) form were stored along 28 days under dark and room temperature or at 4 °C. Initially, the RSV level in γ-CD·RSV-juice was about nine times higher than in RSV-juice (43.1% and 4.8%, respectively), suggesting that the RSV complexation promoted its solubility in the lemon juice, a fact that was still noticed after 28 days of storage. Moreover, regardless the fact that the antioxidant capacity was similar among the juices, the loss of antiradical ABTS•+ capacity in γ-CD·RSV-juice was reduced compared to that of the RSV-juice. Overall, this study allowed concluding that γ-CD can serve as a carrier of RSV, promoting its solubility and eventually protecting its antioxidant stability in lemon juices for at least 28 days.

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Section: Introductionmentioning

confidence: 99%

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Silva

Monteiro

Resende

et al. 2020

Foods

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Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats

Kolling

Franceschi

et al. 2019

An. Acad. Bras. Ciênc.

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How to cite: KOOLING J ET AL. 2019. Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na + , K + -ATPase activities found in the spleen from streptozotocin-induced diabetic rats. An Acad Bras Cienc 91: e20181330.Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1d pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na + , K + -ATPase activity. Wistar rats were divided into non-diabetic groups: Control, ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments. diabetes was induced by a single dose of 60 mg/kg of streptozocin intraperitoneally, and treatments by intragastric gavage once daily for 60 days. Hyperglycemia reduced creatine kinase activity, which was reversed by the administration of resveratrol. Na + , K + -ATPase activity was greatly affected, but it was reversed by resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin. This suggest an energetic imbalance in the spleen of diabetic rats, and in case this also occurs in the diabetic patients, it is possible that resveratrol supplementation could be beneficial to the better functioning of the spleen in diabetic patients.

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RESVERATROL INCLUSION COMPLEX WITH Β-Cyclodextrin (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

Cited by 2 publications

References 30 publications

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Inclusion Complex of Resveratrol with γ-Cyclodextrin as a Functional Ingredient for Lemon Juices

Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats

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