Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3

Bilotta, Sabrina; Paruchuru, Lakshmi Bhargavi; Feilhauer, Katharina; Köninger, Jörg; Lorentz, Axel

doi:10.3390/ijms22147640

Cited by 21 publications

(24 citation statements)

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“…Nevertheless, we also detected a remarkable attenuation of p-ERK expression in mice pretreated with BPE and BPFPE. The effects of polyphenols on ERK have been previously identified in vitro in a study of human mast cells isolated from the intestinal mucosa, which showed that resveratrol inhibited the phosphorylation of ERK [53]. Among the few studies focusing on MAPK-related effects following polyphenol treatment, raspberry polyphenols were shown to reduce the activation of ERK1/2 MAPKs, prevent IkK degradation, and inhibit nuclear translocation of the p65 subunit of NF-κB [25].…”

Section: Discussionmentioning

confidence: 99%

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

et al. 2022

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Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD.

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Section: Discussionmentioning

confidence: 99%

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

et al. 2022

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“…We recently reported that resveratrol inhibits activation of hiMC [40]. As the increase in MC numbers was prevented in duodenum and colon of mice in OVA enteritis and IL-10 −/− mice, we wanted to check for its effects on MC from murine origin.…”

Section: Resveratrol Inhibits Degranulation and Expression Of Pro-inf...mentioning

confidence: 99%

“…Resveratrol (trans-3,4 ,5 trihydroxystilbene, trans-Resveratrol) is mainly found in grapes, berries or peanuts [38,39]. Numerous studies already showed the anti-inflammatory effects of resveratrol in the context of allergy and MC reactivity [24,[40][41][42][43][44]. We have recently shown that resveratrol is a potent inhibitor of primary human intestinal mast cells' (hiMC) activity isolated from surgical tissue from patients undergoing bowel resection [40].…”

Section: Introductionmentioning

confidence: 99%

“…Numerous studies already showed the anti-inflammatory effects of resveratrol in the context of allergy and MC reactivity [24,[40][41][42][43][44]. We have recently shown that resveratrol is a potent inhibitor of primary human intestinal mast cells' (hiMC) activity isolated from surgical tissue from patients undergoing bowel resection [40]. The anti-inflammatory effect of resveratrol was not only shown in vitro [24,40] but also in vivo in murine models of airway inflammation, atopic dermatitis or allergic rhinitis [41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

“…We have recently shown that resveratrol is a potent inhibitor of primary human intestinal mast cells' (hiMC) activity isolated from surgical tissue from patients undergoing bowel resection [40]. The anti-inflammatory effect of resveratrol was not only shown in vitro [24,40] but also in vivo in murine models of airway inflammation, atopic dermatitis or allergic rhinitis [41][42][43][44]. This was confirmed in humans by intranasal administration of resveratrol in children and adults suffering from allergic rhinitis [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Bilotta

Arbogast

Schart

et al. 2022

IJMS

Self Cite

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Mast cells are involved in allergic and other inflammatory diseases. The polyphenol resveratrol is known for its anti-inflammatory properties and may be used as nutraceutical in mast cell associated diseases. We analyzed the effect of resveratrol on mast cells in vivo in ovalbumin-induced allergic enteritis as well as experimental colitis in IL-10−/− mice which received resveratrol via drinking water. Treatment with resveratrol prevented the increase in mast cells in both allergic enteritis and chronic colitis in duodenum as well as in colon. Further, it delayed the onset of diseases symptoms and ameliorated diseases associated parameters such as tissue damage as well as inflammatory cell infiltration in affected colon sections. In addition to the findings in vivo, resveratrol inhibited IgE-dependent degranulation and expression of pro-inflammatory cytokines such as TNF-α in IgE/DNP-activated as well as in LPS-activated bone marrow-derived mast cells. These results indicate that resveratrol may be considered as an anti-allergic and anti-inflammatory plant-derived component for the prevention or treatment of mast cell-associated disorders of the gastrointestinal tract.

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Arsenic‐induced transition of thymic inflammation‐to‐fibrosis involves Stat3‐Twist1 interaction: Melatonin to the rescue

Das,

Mitra,

Ghosh

et al. 2024

BioFactors

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Groundwater arsenic is a notorious toxicant and exposure to environmentally relevant concentrations persists as a healthcare burden across the world. Arsenic has been reported to jeopardize the normal functioning of the immune system, but there are still gaps in the understanding of thymic T cell biology. Immunotoxic influence of arsenic in thymic integrity demands a potent restorative molecule. The objectives of this study were to examine key signaling cross‐talks associated with arsenic‐induced immune alterations in the thymus and propose melatonin as a potential candidate against immunological complications arising from arsenic exposure. Swiss albino mice were exposed to sodium arsenite (0.05 mg/L; in drinking water) and melatonin (IP:10 mg/kg BW) for 28 days. Melatonin successfully protected thymus from arsenic‐mediated tissue degeneration and maintained immune homeostasis including T cell maturation and proliferation by mitigating oxidative stress through Nrf2 upregulation. Additionally, melatonin exerted ameliorative effect against arsenic‐induced apoptosis and inflammation by inhibiting p53‐mediated mitochondrial cell death pathway and NF‐κB‐p65/STAT3‐mediated proinflammatory pathway, respectively. For the first time, we showed that arsenic‐induced profibrotic changes were inhibited by melatonin through targeting of inflammation‐associated EMT. Our findings clearly demonstrate that melatonin can be a viable and promising candidate in combating arsenic‐induced immune toxicity with no collateral damage, making it an important research target.

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Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3

Cited by 21 publications

References 50 publications

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

Resveratrol Treatment Prevents Increase of Mast Cells in Both Murine OVA Enteritis and IL-10−/− Colitis

Arsenic‐induced transition of thymic inflammation‐to‐fibrosis involves Stat3‐Twist1 interaction: Melatonin to the rescue

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