Resveratrol loaded nanoparticles attenuate cognitive impairment and inflammatory markers in PTZ-induced kindled mice

Siddiqui, Mobin A.; Akhter, Juheb; Aarzoo,; Bashir, Dar Junaid; Manzoor, Saliha; Rastogi, Shweta; Arora, Indu; Aggarwal, Nidhi; Samim, Mohd

doi:10.1016/j.intimp.2021.108287

Cited by 15 publications

(6 citation statements)

References 48 publications

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“…Our results are in corroboration with the earlier finding on PTZ-induced upregulation of c-fos expression in 7 dpf zebrafish larvae and also in rodent models. , It is well-reported that PTZ exposure increases c-fos expression by several fold in different regions of the zebrafish larval brain, and the antiseizure entity reduces its expression. ,, Altogether, our results demonstrated an ameliorated effect of TPGS-LA conjugate as compared to native LA in terms of latency in seizures, reduced hyperactivity, and downregulation of c-fos gene expression which are the markers of epilepsy, thus reflecting an enhanced protective effect of TPGS-LA as compared to native LA in PTZ-induced convulsions.…”

Section: Resultssupporting

confidence: 92%

R-α-Lipoic Acid Conjugated to d-α-Tocopherol Polyethylene Glycol 1000 Succinate: Synthesis, Characterization, and Effect on Antiseizure Activity

Ruchika

Kumari

Dhiman

et al. 2022

J. Agric. Food Chem.

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α-Lipoic acid (LA), a dithiol micronutrient, acts as a vital cofactor in various cellular catabolic reactions and is also known as a universal antioxidant. The therapeutic efficacy of LA is compromised by a poor aqueous solubility as well as a short halflife. In the present study, LA was conjugated to D-α-tocopherol polyethylene glycol succinate (TPGS) using carbodiimideacid− alcohol coupling reaction. The synthesized conjugate (TPGS-LA) was characterized using 1 H and 13 C nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FT-IR), UV−vis spectroscopy, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The TPGS-LA conjugate was demonstrated to be biocompatible and to have better anticonvulsion activity as compared to native LA in pentylenetetrazol (PTZ)-induced convulsions in zebrafish. Moreover, zebrafish larvae pretreated with TPGS-LA conjugate demonstrated a significant (p < 0.05) reduction of protein carbonylation levels and downregulation of c-fos expression during seizures as compared to native LA. Conclusively, the present findings demonstrate that the TPGS-LA conjugate can be a promising approach for the delivery of LA.

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Section: Resultssupporting

confidence: 92%

R-α-Lipoic Acid Conjugated to d-α-Tocopherol Polyethylene Glycol 1000 Succinate: Synthesis, Characterization, and Effect on Antiseizure Activity

Ruchika

Kumari

Dhiman

et al. 2022

J. Agric. Food Chem.

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“…• TLR pathway inhibitor drugs: Research on selective TLR pathway blockade strategy (IL-1β/IL-1βRaxis) has generated some molecules that have shown antiepileptic efficacy in animal models. Among them, perhaps the most promising is resveratrol [115].…”

Section: Future Therapeutic Strategiesmentioning

confidence: 99%

Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies

et al. 2022

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Immunologic and neuroinflammatory pathways have been found to play a major role in the pathogenesis of many neurological disorders such as epilepsy, proposing the use of novel therapeutic strategies. In the era of personalized medicine and in the face of the exhaustion of anti-seizure therapeutic resources, it is worth looking at the current or future possibilities that neuroimmunomodulator or anti-inflammatory therapy can offer us in the management of patients with epilepsy. For this reason, we performed a narrative review on the recent advances on the basic epileptogenic mechanisms related to the activation of immunity or neuroinflammation with special attention to current and future opportunities for novel treatments in epilepsy. Neuroinflammation can be considered a universal phenomenon and occurs in structural, infectious, post-traumatic, autoimmune, or even genetically based epilepsies. The emerging research developed in recent years has allowed us to identify the main molecular pathways involved in these processes. These molecular pathways could constitute future therapeutic targets for epilepsy. Different drugs current or in development have demonstrated their capacity to inhibit or modulate molecular pathways involved in the immunologic or neuroinflammatory mechanisms described in epilepsy. Some of them should be tested in the future as possible antiepileptic drugs.

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“…44 Siddiqui et al encapsulated resveratrol in glutathione-coated collagen nanoparticles' core and found that it had a favorable impact in reducing cognitive impairment in kindled mice. 45 In this study, we found that L. casei ATCC 393-SeNPs had better effects than L. casei ATCC 393 in improving cognitive impairment in AD model mice.…”

mentioning

confidence: 59%

Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis

Qiao¹,

Chen²,

Song³

et al. 2022

IJN

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The bidirectional communication between the gut and the central nervous system mediated by gut microbiota is closely related to the occurrence and development of neurodegenerative diseases, including Alzheimer's disease (AD). Selenium (Se) has been identified as playing a role against AD. Probiotics have beneficial effects on host brain function and behavior by modulating the microbiota-gut-brain axis. Herein, we evaluated the protective effects of Lactobacillus casei ATCC 393 (L. casei ATCC 393) and selenium nanoparticles-enriched L. casei ATCC 393 (L. casei ATCC 393-SeNPs) against D-galactose/aluminum chloride-induced AD model mice. Methods: The Morris Water Maze (MWM) test was used to assess cognitive function of mice. The morphology and histopathological changes, antioxidant capacity and immune responses in the brain and ileum were evaluated. The alterations in intestinal permeability of the mice were determined using FITC-dextran. Gut microbiota composition was assessed using 16s rRNA sequencing. Results: Thirteen weeks intervention with L. casei ATCC 393 or L. casei ATCC 393-SeNPs significantly improved cognitive dysfunction, and minimized amyloid beta (Aβ) aggregation, hyperphosphorylation of TAU protein, and prevented neuronal death by modulating Akt/cAMP-response element binding protein (CREB)/brain-derived neurotrophic factor (BDNF) signaling pathway. Moreover, compared with L. casei ATCC 393, L. casei ATCC 393-SeNPs further effectively mitigated intestinal barrier dysfunction by improving antioxidant capacity, regulating immune response, restoring gut microbiota balance, and increasing the level of short-chain fatty acids and neurotransmitters, thereby inhibiting the activation of microglia and protecting brain neurons from neurotoxicity such as oxidative stress and neuroinflammation. Conclusion: These findings indicated that targeting the microbiota-gut-brain axis with L. casei ATCC 393-SeNPs may have therapeutic potential for the deficits of cognitive function in the AD model mice. Thus, we anticipate that L. casei ATCC 393-SeNPs may be a promising and safe Se nutritional supplement for use as a food additive to prevent the neurodegenerative disease.

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Resveratrol loaded nanoparticles attenuate cognitive impairment and inflammatory markers in PTZ-induced kindled mice

Cited by 15 publications

References 48 publications

R-α-Lipoic Acid Conjugated to d-α-Tocopherol Polyethylene Glycol 1000 Succinate: Synthesis, Characterization, and Effect on Antiseizure Activity

R-α-Lipoic Acid Conjugated to d-α-Tocopherol Polyethylene Glycol 1000 Succinate: Synthesis, Characterization, and Effect on Antiseizure Activity

Immune Mechanism of Epileptogenesis and Related Therapeutic Strategies

Selenium Nanoparticles-Enriched Lactobacillus casei ATCC 393 Prevents Cognitive Dysfunction in Mice Through Modulating Microbiota-Gut-Brain Axis

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