Resveratrol Nanoparticle’s Formulation - In Diabetic Nephropathy

Abstract

Resveratol a powerful antioxidant but having poor solubility, poor bioavailability, short half-life and chemically unstable. Such compound is changed and transformed to novel drug by using nanoparticles/nano-formulation which not only overwhelmed the problems of free Resveratrol but also provided site specific delivery and unique accumulation of particles inside the cell especially mitochondria which may be helpful to prevent ROS mediated injury particularly in Diabetic nephropathy.

Berbamine application beyond cancer

“…A new potential target in diabetic nephropathy has been identified. [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57] The Wnt/β-catenin signaling pathway is involved in mesangial cell extracellular matrix (ECM) production (MCs). 58 Through the JNK/NF-B/NADPH oxidase/ROS pathway, high glucose promotes renal mesangial cell proliferation and fibronectin expression.…”