Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model

Li, Huagang; Wang, Jing; Wang, Pu; Yan, Rong; Li-ping, Chen

doi:10.1016/j.jstrokecerebrovasdis.2015.09.004

Cited by 47 publications

(32 citation statements)

References 37 publications

(36 reference statements)

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“…In our study, we found that melatonin and resveratrol inhibited the elevated proinflammatory cytokines in the hippocampus of BCCAO-treated rats. Therefore, our results are supportive for the hypothesis that melatonin and resveratrol ameliorate cerebral hypoperfusion-induced cognitive deficits by alleviating oxidonitrosative stress and neuroinflammation [66][67][68] . 329 The central cholinergic system plays a major role in the regulation of blood circulation in the cerebral cortex region [69] .…”

Section: Discussionsupporting

confidence: 86%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

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Objectives: This study was intended to investigate whether treatment with resveratrol and melatonin alone or in combination can exert neurorestorative effects in a rat model of vascular dementia. Methods: Briefly, male Wistar rats were subjected to permanent bilateral common carotid artery occlusion (BCCAO) by surgery. After 4 weeks, the cognitive deficits were assessed using the Morris water maze and novel object recognition tests. The biochemical parameters of oxidative stress and inflammation were also assessed. Results: Rats in the BCCAO group showed cognitive deficits, accompanied by oxidonitrosative stress, neuroinflammation, and a reduction in brain-derived neurotrophic factor (BDNF) in the hippocampus region. Moreover, the acetylcholinesterase activity in the hippocampus was found to be increased in the BCCAO group compared to the sham group. The 4-week treatment with melatonin (10 mg/kg) and resveratrol (20 mg/kg) alone and in combination (melatonin 5 mg/kg and reseveratrol 10 mg/kg) caused a significant improvement in the cognitive deficits induced by BCCAO, accompanied by a reversal of oxidonitrosative stress, neuroinflammation, and BDNF depletion in the hippocampus region. Additionally, the treatment with melatonin and resveratrol significantly decreased acetylcholinesterase activity compared to in the BCCAO group. Melatonin and resveratrol ameliorated the BDNF expression of hippocampal protein. Conclusion: These results emphasize that coadministration of melatonin and resveratrol can be beneficial in BCCAO-induced vascular dementia through changes in BDNF expressions.

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Section: Discussionsupporting

confidence: 86%

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Shen¹,

Tian²,

Sang³

et al. 2016

Neuroimmunomodulation

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“…Furthermore, CREB phosphorylation is a necessary step in the process leading to the generation of new dendritic spines [27]. In addition, the cAMP–CREB signaling cascade is critical for the generation of new neurons in the rodent hippocampus, also facilitating their subsequent morphological maturation [28]. …”

Section: Discussionmentioning

confidence: 99%

“…Coccomyxa gloeobotrydiformis (CGD) significantly increased ERK and CREB phosphorylation in the hippocampus, suggesting that the learning and memory-enhancing effects of CGD might be associated with the ERK/CREB pathway [52]. Li et al reported that pretreatment with resveratrol effectively restored synaptic plasticity in chronic cerebral hypoperfusion rats both functional and structural via PKA-CREB activation [28]. The levels of PKA and cAMP were increased in the rat hippocampus following a step-down inhibitory avoidance task [53].…”

Section: Discussionmentioning

confidence: 99%

Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway

Guo

et al. 2017

Oncotarget

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Ketamine has been reported to impair the capacity for learning and memory. This study examined whether these capacities were also altered in the offspring and investigated the role of the CREB signaling pathway in pregnant rats, subjected to ketamine-induced anesthesia. On the 14th day of gestation (P14), female rats were anesthetized for 3 h via intravenous ketamine injection (200 mg/Kg). Morris water maze task, contextual and cued fear conditioning, and olfactory tasks were executed between the 25th to 30th day after birth (B25-30) on rat pups, and rats were sacrificed on B30. Nerve density and dendritic spine density were examined via Nissl’s and Golgi staining. Simultaneously, the contents of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII), p-CaMKII, CaMKIV, p-CaMKIV, Extracellular Regulated Protein Kinases (ERK), p-ERK, Protein Kinase A (PKA), p-PKA, cAMP-Response Element Binding Protein (CREB), p-CREB, and Brain Derived Neurotrophic Factor (BDNF) were detected in the hippocampus. We pretreated PC12 cells with both PKA inhibitor (H89) and ERK inhibitor (SCH772984), thus detecting levels of ERK, p-ERK, PKA, p-PKA, p-CREB, and BDNF. The results revealed that ketamine impaired the learning ability and spatial as well as conditioned memory in the offspring, and significantly decreased the protein levels of ERK, p-ERK, PKA, p-PKA, p-CREB, and BDNF. We found that ERK and PKA (but not CaMKII or CaMKIV) have the ability to regulate the CREB-BDNF pathway during ketamine-induced anesthesia in pregnant rats. Furthermore, ERK and PKA are mutually compensatory for the regulation of the CREB-BDNF pathway.

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“…In rats with experimentally induced chronic cerebral hypoperfusion, pretreatment with resveratrol restored synaptic plasticity deficits at both functional and structural levels . These findings provide some mechanistic evidence of neuroprotective efficacy of resveratrol in vascular dementia.…”

Section: Resveratrol In Animal Models Of Vascular Dementiamentioning

confidence: 54%

Resveratrol, pterostilbene, and dementia

Lange

2017

BioFactors

106

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Resveratrol is a natural phytoestrogen with neuroprotective properties. Polyphenolic compounds including resveratrol exert in vitro antioxidant, anti-inflammatory, and antiamyloid effects. Resveratrol and its derivative pterostilbene are able to cross the blood-brain barrier and to influence brain activity. The present short review summarizes the available evidence regarding the effects of these polyphenols on pathology and cognition in animal models and human subjects with dementia. Numerous investigations in cellular and mammalian models have associated resveratrol and pterostilbene with protection against dementia syndromes such as Alzheimer's disease (AD) and vascular dementia. The neuroprotective activity of resveratrol and pterostilbene demonstrated in in vitro and in vivo studies suggests a promising role for these compounds in the prevention and treatment of dementia. In comparison to resveratrol, pterostilbene appears to be more effective in combatting brain changes associated with aging. This may be attributed to the more lipophilic nature of pterostilbene with its two methoxyl groups compared with the two hydroxyl groups of resveratrol. The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects. Future clinical trials should be conducted with long-term exposure to preparations of resveratrol and pterostilbene with high bioavailability.

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Resveratrol Reverses the Synaptic Plasticity Deficits in a Chronic Cerebral Hypoperfusion Rat Model

Cited by 47 publications

References 37 publications

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Effect of Melatonin and Resveratrol against Memory Impairment and Hippocampal Damage in a Rat Model of Vascular Dementia

Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway

Resveratrol, pterostilbene, and dementia

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