Maxillofacial abnormalities are the most deleterious to a person's self-esteem and quality of life. Restoration of speech, deglutition, and masticatory functions as well as achieving a normal orofacial appearance are the main objectives of rehabilitation of maxillofacial defects. Any prosthesis can be held in place by anatomical, mechanical, chemical, or surgical anchorage, depending on the clinical scenario. Various methods of retention have evolved over a period of time. Osseointegrated implants have been employed to enhance the retention of facial prosthesis, in the last 20 years. The prosthodontist should be familiar with all the available options, to opt for the appropriate retentive method, while planning for the prosthetic rehabilitation for the patient. In all cases of maxillofacial deformities, optimal outcomes could be a challenging task to accomplish, but careful evaluation, clinical decision-making, and planning can result in prosthesis of acceptable quality that might enhance the patient's quality of life.