Reticuloendothelial Function After Hemorrhage and Hypothermia

Rijen, van; Jj, Ward; Parry, E. W.; Ra, Little

doi:10.1097/00024382-199704000-00010

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Daemen et al [22] showed that hypothermia at around 32-33°C reduced drug clearance in rats compared to normothermic rats. In vitro experiments suggest that this is due to a reduction in the capacity of macrophages to phagocytose foreign particles from the blood [23]. Our results (Figs.…”

Section: Discussionmentioning

confidence: 52%

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Murase

Assanai

Takata

et al. 2015

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 52%

Kinetic analysis of superparamagnetic iron oxide nanoparticles in the liver of body-temperature-controlled mice using dynamic susceptibility contrast magnetic resonance imaging and an empirical mathematical model

Murase

Assanai

Takata

et al. 2015

Magnetic Resonance Imaging

View full text Add to dashboard Cite

“…However, as trauma in the small laboratory animal is accompanied by an inhibition of thermoregulation and a fall in body temperature (50), it is important to exclude any such effects before attributing a change in RES function to trauma per se. Indeed, our earlier experiments using the model described in the present paper showed that there was no early depression in the phagocytic rate provided that normothermia was maintained (52); thus, in the current experiments care was taken to ensure that all animals were kept normothermic.…”

Section: Discussionmentioning

confidence: 84%

Effects of Colloidal Resuscitation Fluids on Reticuloendothelial Function and Resistance to Infection after Hemorrhage

Rijen

Ward

Little

1998

Clin Diagn Lab Immunol

Self Cite

View full text Add to dashboard Cite

The effects of three resuscitation fluids, hydroxyethyl starch (HES), Haemaccel, and fresh autologous blood, on reticuloendothelial system phagocytic and catabolic functions and resistance to infection after 40% hemorrhages in BALB/c mice were studied. The mice, anesthetized with isoflurane, were bled over a 10-min period, left hypovolemic for 30 min, and then resuscitated with their shed blood or the same volume of asanguineous fluid. Normothermia was maintained throughout the experiments. The uptake and catabolism of intravenously injected double-labelled sheep erythrocytes (51Cr-125I-SRBC) in liver and spleen were determined at 1 and 48 h after hemorrhage. No significant changes in the uptake or catabolism of SRBC in liver or spleen were found at 1 h after hemorrhage and resuscitation with any of the fluids. However, at 48 h a significant increase in liver uptake of SRBC was seen in animals resuscitated with either Haemaccel or HES compared to that in animals resuscitated with shed blood or in animals subjected to a sham operation. The increase in liver uptake was accompanied by a small decrease in spleen uptake in animals resuscitated with Haemaccel but not with HES. No great changes in catabolic activity were seen at 48 h, although activity levels tended to be higher in animals resuscitated with Haemaccel. Separate groups of animals were challenged by an intraperitoneal injection with live Escherichia coliat 1 or 48 h after hemorrhage and resuscitation. Sixty-four percent of the animals resuscitated with shed blood survived the challenge with E. coli at 1 h after hemorrhage, whereas only 10 and 0% survival was seen for animals resuscitated with Haemaccel and HES, respectively. At 48 h survival was 80% for shed-blood-resuscitated animals and 60 and 70% for Haemaccel- and HES-resuscitated animals, respectively.

show abstract

“…This deranged circulation can lead to renal failure, pulmonary oedema, metabolic acidosis and inadequate cerebral blood flow 46. Cooling also impairs clotting,50 depresses the immune system,51disrupts serum potassium homeostasis,52 alters acid base balance,53 and is associated with hypoglycaemia 54. Hypothermia may cause gastrointestinal lesions in the developing animal, although the data are somewhat contradictory 55…”

Section: Adverse Effects Of Hypothermiamentioning

confidence: 99%