Retina nerve fiber layer and choroidal thickness changes in obstructive sleep apnea syndrome

Özge, Gökhan; Doğan, Deniz; Koylu, Mehmet Talay; Ayyıldız, Önder; Akıncıoğlu, Dorukcan; Mumcuoğlu, Tarkan; Mutlu, Fatih Mehmet

doi:10.1080/00325481.2016.1159118

Cited by 24 publications

(17 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 3 ] Acer et al demonstrated that migraine patients without aura had decreased peripapillary RNFL thickness in temporal and nasal-superior sectors compared with control patients. [ 4 ] Ferrandez et al [ 5 ] found a decrease in RNFL thickness in patients with severe obstructive sleep apnoea which could be confirmed by Ozge et al [ 6 ] Also, Alzheimer disease was found to lead to significant RNFL thinning. [ 7 ]…”

Section: Introductionmentioning

confidence: 83%

Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Lamparter

Schmidtmann²,

Schuster

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

BackgroundGlaucoma is a neurodegenerative disease, leading to thinning of the retinal nerve fibre layer (RNFL). The exact influence of ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFL thickness (RNFLT) is unknown and was analysed in a subgroup of the Gutenberg Health Study (GHS).MethodsGlobal peripapillary RNFLT was measured in 3224 eyes of 1973 subjects (49% female) using spectral-domain optical coherence tomography (SD-OCT). The association of age, sex, ocular, cardiovascular, morphometric, lifestyle and cognitive factors on RNFLT was analysed using Pearson correlation coefficient and fitting a linear mixed model.ResultsIn the univariable analysis highest correlations were found for axial length (r = -0.27), spherical equivalent (r = 0.24), and glaucoma (r = -0.15) (p<0.0001, respectively). Other significant correlations with RNFLT were found for age, sex, intraocular pressure, systemic hypertension and systolic blood pressure, previous eye surgery, cholesterol, homocysteine, history of coronary artery disease, history of myocardial infarction, apnoea, diabetes and alcohol intake, p<0.05, respectively. Body length, body weight, BMI, diastolic blood pressure, blood glucose, HbA1c, history of apoplexy, cognitive function, peripheral artery disease, tinnitus, migraine, nicotine intake, central corneal thickness, and pseudophakia were not significantly correlated with RNFLT. The regression model revealed a significant relationship between RNFLT and age in decades (p<0.02), spherical equivalent (p<0.0001), axial length (p<0.0001), glaucoma (p<0.0001), tinnitus (p = 0.04), apnoea (p = 0.047), homocysteine (p = 0.05) and alcohol intake >10g/d for women and >20g/d for men (p = 0.02). Glaucoma, apnoea, higher homocysteine, higher alcohol intake and higher axial length as well as age were related to decreased RNFLT while higher spherical equivalent or history for tinnitus were related to thicker RNFL.ConclusionRNFLT is related to age, ocular parameters and lifestyle factors. Considering these parameters in normative databases could improve the evaluation of peripapillary RNFLT. It is necessary to evaluate if a reduction of alcohol intake as well as the therapy of apnea or high homocysteine levels could positively influence RNFLT.

show abstract

Section: Introductionmentioning

confidence: 83%

Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Lamparter

Schmidtmann²,

Schuster

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…This suggests decreased ocular blood flow and possibly decreased CT in those patients. This suggestion evaluated with the increased CT found in the study by Ozge et al 1 is in favour of the autonomic dysfunction in patients with OSAS. We would also want to learn the thoughts of the authors about this assumption.…”

mentioning

confidence: 77%

“…We have read with interest the article entitled ‘Retina nerve fiber layer and choroidal thickness changes in obstructive sleep apnea syndrome’ by Ozge et al 1. We express our gratitude to the authors for demonstrating significant differences at some measurement points in macular and peripapillary retinal nerve fibre layer (RNFL) and choroidal thickness (CT) in patients with obstructive sleep apnoea syndrome (OSAS).…”

mentioning

confidence: 99%

Comment on: ‘Retina nerve fiber layer and choroidal thickness changes in obstructive sleep apnea syndrome’ by Ozgeet al

Uzun

2016

Postgraduate Medical Journal

View full text Add to dashboard Cite

“…This predominantly temporal reduction of the RNFL thickness seems to be consistent in the neuro-ophthalmologic literature, highlighting its usefulness as a biomarker of neurodegeneration. On the other hand, glaucoma leads to a greater decrease in the inferior RNFL quadrant thickness [ 17 ], and patients with obstructive sleep apnea syndrome present with RNFL thinning in the nasal quadrant and choroidal thickening (this change may be caused by the pathophysiology of the neurodegeneration process in obstructive sleep apnea syndrome) [ 18 ]. Therefore, each pathology may lead to a different fingerprint of damage in the optic nerve [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Influence of cardiovascular condition on retinal and retinal nerve fiber layer measurements

et al. 2017

View full text Add to dashboard Cite

ObjectiveTo assess changes in the retinal nerve fiber layer (RNFL) and macula in subjects with cardiovascular risk factors or subclinical ischemia.DesignProspective and observational study.MethodsA total of 152 healthy men underwent cardiovascular examination, including quantification of subclinical atheroma plaques by artery ultrasound scans, blood analysis, and a complete ophthalmic evaluation, including spectral-domain optical coherence tomography. The variables registered in cardiovascular examination were quantification of classic major risk factors, subclinical atheroma plaques by artery ultrasound scans, and analytical records. The ophthalmic evaluation registered RNFL and macular thickness.ResultsMean subject age was 51.27±3.71 years. The 40 subjects without classic cardiovascular risk factors did not show differences in RNFL and macular thicknesses compared with the 112 subjects with at least one risk factor (except in sector 9 that showed higher thicknesses in subjects with ≥1 risk factor). Comparison between the group of subjects with and without atheroma plaques revealed no differences in RNFL and macular thicknesses. The sub-analysis of subjects with subclinical atheroma plaques in the common carotid artery revealed a significant reduction in central macular thickness in the left eye compared with the right eye (p = 0.016), RNFL in the superior quadrant (p = 0.007), and the 11 o’clock sector (p = 0.020). Comparison between smokers and nonsmokers revealed that smokers had significant thinning of the central macular thickness (p = 0.034), the nasal RNFL quadrant (p = 0.006), and the 3 and 5 o’clock sectors (p = 0.016 and 0.009).ConclusionsClassic cardiovascular risk factors do not cause RNFL or macular thickness reduction, but tobacco smoking habit reduces nasal RNFL thickness. Subclinical atherosclerosis in the common carotid artery associates a reduction in central macular and nasal RNFL quadrant thicknesses in the left eye compared with the right eye.

show abstract

Retina nerve fiber layer and choroidal thickness changes in obstructive sleep apnea syndrome

Abstract: The choroidal thickening in patients with OSAS may be associated with the pathophysiology of the neurodegeneration process of the disease.

Cited by 24 publications

References 36 publications

Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness

Comment on: ‘Retina nerve fiber layer and choroidal thickness changes in obstructive sleep apnea syndrome’ by Ozgeet al

Influence of cardiovascular condition on retinal and retinal nerve fiber layer measurements

Contact Info

Product

Resources

About