Retinal and optic nerve head ischemic disorders and atherosclerosis:

Hayreh, Sohan Singh

doi:10.1016/s1350-9462(98)00016-0

Cited by 73 publications

(39 citation statements)

References 124 publications

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“…It has been postulated that in some atherosclerotic individuals this mechanism may play an important role in the development of ischaemic disorders of the retina and optic nerve head, and possibly of glaucomatous optic neuropathy, particularly in NTG. 36 Vasospastic syndrome is an established risk factor for glaucoma in addition to increased IOP. 2,37 In NTG where glaucomatous damage occurs without elevated IOP, the phenomenon of vasospasm or ischaemia is assumed to prevail in the pathogenesis over barotraumas.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Woo

Kim

et al. 2007

Eye

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Purpose Homozygous polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and resultant hyperhomocysteinaemia have been established as an independent risk factor for vascular diseases. There are evidences that vascular abnormalities are involved in the pathogenesis and progression of normaltension glaucoma (NTG). In the present study, we were to find out the associations between 677C4T and 1298A4C polymorphisms of the MTHFR gene and NTG. Methods This was a retrospective, casecontrolled study enrolling 78 NTG patients and 100 controls. DNA from peripheral blood lymphocytes was extracted and the genotypes of polymorphisms (677C4T and 1298A4C) in the MTHFR gene were determined using PCR followed by restriction enzyme digestion. The frequencies of the polymorphic genotypes in the patients with NTG and controls were compared. Results The frequencies of the polymorphisms of the MTHFR gene (677C4T and 1298A4C) in the NTG patients were not significantly different from those of controls. But the younger NTG patients (age at diagnosis p45 years) showed significantly higher prevalence of 677C4T polymorphism than the older NTG patients (age at diagnosis 445 years) (TT genotype, 38.9 vs 11.9%, P ¼ 0.006, OR ¼ 4.71, 95% CI ¼ 1.49-14.9) and than the younger control subgroup (TT genotype, 38.9 vs 6.1%, P ¼ 0.001, OR ¼ 9.86, 95% CI ¼ 2.23-42.4). Conclusions The 677C4T polymorphism was significantly associated with NTG in the younger patients, while 1298A4C polymorphism was not. This suggests that 677C4T polymorphism of the MTHFR gene can be a genetic risk factor of NTG in Korean population.

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Section: Discussionmentioning

confidence: 99%

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Woo

Kim

et al. 2007

Eye

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“…Because arterial hypertension and artherosclerosis cause vascular accidents or act as a risk factor for their development, [16][17][18] it suggests that vascular accidents or related events may lead to localized RNFL defects. It is also supported by the fact that RNFL defects are common in patients with early diabetic retinopathy and by the fact that RNFL defects are frequently followed by cotton wool spots.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of patients with a localized retinal nerve fiber layer defect and normal optic disc appearance

Lee

Kim

Kee

2012

Eye

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“…3 In individuals with atherosclerotica the susceptibility becomes higher due to serotonin-enhancing platelet aggregation on atheromata of ocular arteries. 3,4 The most commonly-reported ophthalmic side effect of SSRIs is acute glaucoma. There is a single report of central retinal vein thrombosis in association with citalopram.…”

Section: Possible Ssri Side Effectsmentioning

confidence: 99%

Keep an eye on the SSRI: help avoid possible sight-threatening adverse events

Lochhead

2016

Br J Gen Pract

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Retinal and optic nerve head ischemic disorders and atherosclerosis:

Cited by 73 publications

References 124 publications

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Investigation of the association between 677C>T and 1298A>C 5,10-methylenetetra- hydrofolate reductase gene polymorphisms and normal-tension glaucoma

Characteristics of patients with a localized retinal nerve fiber layer defect and normal optic disc appearance

Keep an eye on the SSRI: help avoid possible sight-threatening adverse events

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