Retinal changes in patients with major depressive disorder – A controlled optical coherence tomography study

Schönfeldt‐Lecuona, Carlos; Schmidt, Arno; Kregel, Thomas; Kassubek, Jan; Dreyhaupt, Jens; Freudenmann, Roland W.; Connemann, Bernhard J.; Pinkhardt, Elmar H.; Gahr, Maximilian

doi:10.1016/j.jad.2017.11.077

Cited by 36 publications

(21 citation statements)

References 51 publications

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“…194 However, most of the evidence comparing MD patients with healthy controls to date found no statistically significant difference in OCT measures although differences within MD groups were more profound (Table 1). 87,88,195 Duration and severity of disease was observed to correlate negatively with GCL and IPL volumes and positively with global RNFL thickness; however, the evidence is weak for all measures possibly owing to the majority of MD patients taking psychotropic medication. 87,194 Finally, the total retinal volume of the left eye has been shown to be greater than the right eye in MD patients, indicating a possible hemispherespecific lateralisation of cognitive processing.…”

Section: Oct In Major Depressionmentioning

confidence: 92%

“…87,194 Finally, the total retinal volume of the left eye has been shown to be greater than the right eye in MD patients, indicating a possible hemispherespecific lateralisation of cognitive processing. 195 This idea has been compounded by positron emission tomography (PET) studies showing increased orbitofrontal and prefrontal activity in healthy volunteers during temporary states of sadness, 196,197 with MD patients more often having altered left prefrontal functioning. [198][199][200][201]…”

Section: Oct In Major Depressionmentioning

confidence: 99%

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Retinal correlates of psychiatric disorders

Almonte

Capellàn

Yap

et al. 2020

Therapeutic Advances in Chronic Disease

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Diagnosis and monitoring of psychiatric disorders rely heavily on subjective selfreports of clinical symptoms, which are complicated by the varying consistency of accounts reported by patients with an impaired mental state. Hence, more objective and quantifiable measures have been sought to provide clinicians with more robust methods to evaluate symptomology and track progression of disease in response to treatments. Owing to the shared origins of the retina and the brain, it has been suggested that changes in the retina may correlate with structural and functional changes in the brain. Vast improvements in retinal imaging, namely optical coherence tomography (OCT) and electrodiagnostic technology, have made it possible to investigate the eye at a microscopic level, allowing for the investigation of potential biomarkers in vivo. This review provides a summary of retinal biomarkers associated with schizophrenia, bipolar disorder and major depression, demonstrating how retinal biomarkers may be used to complement existing methods and provide structural markers of pathophysiological mechanisms that underpin brain dysfunction in psychiatric disorders.

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Section: Oct In Major Depressionmentioning

confidence: 92%

Section: Oct In Major Depressionmentioning

confidence: 99%

Retinal correlates of psychiatric disorders

Almonte

Capellàn

Yap

et al. 2020

Therapeutic Advances in Chronic Disease

View full text Add to dashboard Cite

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“…Kim [11] measured subfoveal choroidal and central foveal thicknesses of patients with acute anterior uveitis using a SD-OCT, and found a significant increase in patients during the active period of acute anterior uveitis. Schönfeldt-Lecuona [15] measured the total retinal volume and thickness as well as the volumes and thickness for 10 retinal layers of major depression patients and healthy controls with a SD-OCT, and found a 0.03mm 3 retinal total volume difference between the right and left eye in the major depression patients, which was the only difference between the patients and the healthy controls. Martinez-Lapiscina [16] studied retinal nerve fibre layer thickness and macular volume in multiple sclerosis patients, proved a higher disability worsening rate in patients with retinal nerve fibre layer thickness of less than or equal to 87 m. El-Shazly [17] performed retinal nerve fibre layer and ganglion cell layer thickness measurement using SD-OCT on active smokers and passive smokers, and proved that there was retinal nerve fibre layer thinning which was related to the number of cigarettes/day in active smokers.…”

Section: Oct In Ophthalmologymentioning

confidence: 99%

Application of optical coherence tomography in clinical diagnosis

Wang

Liu

Lou

et al. 2019

Journal of X-Ray Science and Technology: Clinical Applications

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BACKGROUND: Optical coherence tomography (OCT) is a non-invasive diagnosing tool used in clinics. Due to its high resolution (<10um), it is appropriate for the early detection of tiny infections. It has been widely used in diagnosis and treatment of diseases, evaluation of therapeutic efficacy, and monitoring of various physiological and pathological processes. OBJECTIVE: To systemically review literature to summarize the clinic application of OCT in recent years. METHODS: For clinic applications that OCT has been applied, we selected studies that describe the most relevant works. The discussion included: 1) which tissue could be used in the OCT detection, 2) which character of different tissue could be used as diagnosing criteria, 3) which diseases and pathological process have been diagnosed or monitored using OCT imaging, and 4) the recent development of clinic OCT diagnosing. RESULTS: The literature showed that the OCT had been listed as a routine test choice for ophthalmic diseases, while the first commercial product for cardiovascular OCT detection had gotten clearance. Meanwhile, as the development of commercial benchtop OCT equipment and tiny fiber probe, the commercial application of OCT in dermatology, dentistry, gastroenterology and urology also had great potential in the near future. CONCLUSIONS: The analysis and discussions showed that OCT, as an optical diagnosing method, has been used successfully in many clinical fields, and has the potential to be a standard inspection method in several clinic fields, such as dermatology, dentistry and cardiovascular.

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“…We read with interest the article entitled "Retinal changes in patients with major depressive disorder -A controlled optical coherence tomography study" recently published by Schönfeldt-Lecuona et al 1 in your journal.…”

Section: Accepted Manuscriptmentioning

confidence: 99%