2021
DOI: 10.1016/j.phrs.2021.105488
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Retinal damage in a new model of hyperglycemia induced by high-sucrose diets

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Cited by 20 publications
(36 citation statements)
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“…Interestingly in a drosophila model of hyperglycemia developed by raising adult fruit flies under high-sucrose regimens, signs of autophagy deregulation, such as significant and progressive increase of LC3 and p62 staining, with accumulation of autophagosomes were observed in eye sections (Catalani et al, 2021).…”
Section: The Role Of Autophagy In Animal Models Of Diabetic Retinopathymentioning
confidence: 99%
“…Interestingly in a drosophila model of hyperglycemia developed by raising adult fruit flies under high-sucrose regimens, signs of autophagy deregulation, such as significant and progressive increase of LC3 and p62 staining, with accumulation of autophagosomes were observed in eye sections (Catalani et al, 2021).…”
Section: The Role Of Autophagy In Animal Models Of Diabetic Retinopathymentioning
confidence: 99%
“…Adult Drosophila (5–6 days old) were transferred for 10 days on either the standard food (5% sucrose, corresponding to 0.146 M) or the high-sucrose diet (35% w / v , 1.022 M), obtained changing sucrose independently while keeping the other components constant. As previously detailed [ 22 ], standard food of flies contained carbohydrates and protein/fat reservoir; supplemental sucrose increased carbohydrate energy at 90% of calories from carbohydrates (standard food: 72%). Where indicated, flies were reared on diets supplemented with Lisosan G. A preliminary dose–response of Lisosan G was tested in hyperglycemic Drosophila using 300, 100, and 10 µg/mL [ 34 ] for 10 days, evaluating general behaviors of flies and their response to light.…”
Section: Methodsmentioning
confidence: 98%
“…All experiments were performed with female and male adult D. melanogaster (Oregon-R strain from Bloomington Drosophila Stock Center, Indiana University Bloomington, IN, USA). As previously reported [ 20 , 22 , 35 ], flies were routinely raised on a standard cornmeal agar food (pH 5.5) at 25 °C with minor modifications. Fly food was prepared as follows: 100 g of yellow cornmeal, 100 g of brewer’s yeast, 8 g of agar, and 75 g of sucrose (5% w / v ) were mixed and dissolved by adding warm plain water to a final volume of 1.5 l, the hydration source of the flies.…”
Section: Methodsmentioning
confidence: 99%
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