Retinal detachment presumably associated with topiramate

Dey, KK; Das, Sanghamitra; Mishra, Amit V.; Guha, GS

doi:10.4103/0028-3886.42005

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…Two cases in the neurology literature report retinal detachments associated with the usage of topiramate for one year or more in two individuals. 7 Each patient sought ophthalmic evaluation after the onset of symptoms of flashes. One patient was treated with laser retinopexy and the other with encircling scleral buckle.…”

Section: Discussionmentioning

confidence: 99%

Topiramate-induced macular neurosensory retinal detachment

Rosenberg¹,

Maguire

Benevento

2017

American Journal of Ophthalmology Case Reports

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PurposeTo present a previously unreported retinal side-effect from topiramate use in two cases.ObservationsMacular neurosensory retinal detachments were seen in two patients shortly after beginning oral topiramate. The macular detachments resolved shortly after discontinuing this medication.Conclusions and importanceAs these two cases represent the first reports of topiramate-induced macular neurosensory retinal detachment, clinicians should be aware of this potential ocular side effect when administering this medication.

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Section: Discussionmentioning

confidence: 99%

Topiramate-induced macular neurosensory retinal detachment

Rosenberg¹,

Maguire

Benevento

2017

American Journal of Ophthalmology Case Reports

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“…In another report on two cases, authors attributed the evolution of rhegmatogenous retinal detachment to long-term administration of TPM (in one case 18 months and in another case 12 months) 75. In both cases, the presenting symptom was flashing.…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 97%

Topiramate and the vision: a systematic review

Abtahi¹,

Abtahi²,

Fazel³

et al. 2012

OPTH

101

106

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Background and purposeTopiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue.MethodsFor the time period 1996–2011, a PubMed search was made for the studies concerning the adverse/beneficial effects of TPM on vision. Overall, 404 citations out of a total of 2756 TPM-related studies were examined for relevance.ResultsA total of 74 relevant studies were reviewed, 65 of which comprise small observational studies describing the ophthalmic side effects of TPM in 84 patients. Of these patients, 66 were affected by ciliochoroidal effusion syndrome as the cardinal ocular side effect of TPM (17 cases of myopic shift and 49 cases of angle closure glaucoma). A comprehensive statistical analysis is provided on these 66 subjects. Other rare side effects of TPM on the vision were also reviewed, including massive choroidal effusion, ocular inflammatory reactions, visual field defects, probable effects on retina, cornea, and sclera, and neuroophthalmologic complications. In addition, a framework is provided to classify these results.DiscussionDue to the expanding spectrum of indications for the administration of TPM, neurologists and psychiatrists should be aware of its diverse ocular side effects. In conclusion, ocular complications following this drug should be taken seriously and be subjected to ophthalmic counseling.

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“…A delayed ocular side effect due to topiramate is well known and can occur even after taking a single tablet. 4 Dey et al 5 presented two patients who developed rhegmatogenous retinal detachments (RRDs) while on topiramate and had flashes. However, the association seems to be not substantiated 6 as one of the cases had lattice, and the RRDs most likely happened secondary to posterior vitreous detachment which may not be related to topiramate use.…”

Section: Discussionmentioning

confidence: 99%