Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Vieira, Lina; Silva, Nuno Filipe Aguiar; Santos, Arnaldo; Anjos, Rita; Pinto, Luís Abegão; Vicente, André; Borges, Bárbara; Ferreira, Joana Tavares; Amado, Duarte; Cunha, João Paulo

doi:10.1097/wno.0000000000000229

Cited by 36 publications

(24 citation statements)

References 27 publications

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“…Viera et al 15 reported a 34% to 40% decrease in the thickness of the retinal ganglion cell layer (compared with a control group) in eight patients with EMB-induced and nutritional optic neuropathy. 15 In the present longitudinal analysis, we also observed initial cpRNFL swelling within 3 months after symptom onset. Initial decrease of GCIPL, reflecting early axonal damage caused primarily by EMB toxicity, was more remarkable in inner locations than in outer locations.…”

Section: Discussionmentioning

confidence: 98%

“…Early GCIPL loss, which refers to primary axonal loss in some optic neuropathies, was previously reported. 14,15 Balducci et al 14 detected damage to the GCIPL starting 6 weeks before visual loss in Leber's hereditary optic neuropathy (LHON). Viera et al 15 reported a 34% to 40% decrease in the thickness of the retinal ganglion cell layer (compared with a control group) in eight patients with EMB-induced and nutritional optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Balducci et al 14 detected damage to the GCIPL starting 6 weeks before visual loss in Leber's hereditary optic neuropathy (LHON). Viera et al 15 reported a 34% to 40% decrease in the thickness of the retinal ganglion cell layer (compared with a control group) in eight patients with EMB-induced and nutritional optic neuropathy. 15 In the present longitudinal analysis, we also observed initial cpRNFL swelling within 3 months after symptom onset.…”

Section: Discussionmentioning

confidence: 99%

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Ganglion Cell Layer and Inner Plexiform Layer as Predictors of Vision Recovery in Ethambutol-Induced Optic Neuropathy: A Longitudinal OCT Analysis

Lee

Choi

Park

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Ganglion Cell Layer and Inner Plexiform Layer as Predictors of Vision Recovery in Ethambutol-Induced Optic Neuropathy: A Longitudinal OCT Analysis

Lee

Choi

Park

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…SD-OCT analysis of the GCL is expanding in the neuro-ophthalmological field, 8 with the study of diseases such as non-arteritic ischaemic optic neuropathy, 9,10 optic neuritis, [11][12][13][14] papilloedema due to idiopathic intracranial hypertension 15 and toxic and nutritional optic neuropathy. 16 The purpose of this study is to evaluate the macular GCL and peripapillary RNFL thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions.…”

Section: Introductionmentioning

confidence: 99%

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Anjos

Vieira

Costa

et al. 2016

Neuro-Ophthalmology

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The purpose of this study is to evaluate the macular ganglion cell layer (GCL) and peripapillary retinal nerve fibre layer (RNFL) thickness in patients with unilateral posterior cerebral artery (PCA) ischaemic lesions using spectral-domain optical coherence tomography (SD-OCT). A prospective, case-control study of patients with unilateral PCA lesion was conducted in the neuro-ophthalmology clinic of Centro Hospitalar Lisboa Central. Macular and peripapillary SD-OCT scans were performed in both eyes of each patient. Twelve patients with PCA lesions (stroke group) and 12 healthy normal controls were included in this study. Peripapillary RNFL comparison between both eyes of the same subject in the stroke group found a thinning in the superior-temporal (p = 0.008) and inferior-temporal (p = 0.023) sectors of the ipsilateral eye and nasal sector (p = 0.003) of the contralateral eye. Macular GCL thickness comparison showed a reduction temporally in the ipsilateral eye (p = 0.004) and nasally in the contralateral eye (p = 0.002). Peripapillary RNFL thickness was significantly reduced in both eyes of patients with PCA compared with controls, affecting all sectors in the contralateral eye and predominantly temporal sectors in the ipsilateral eye. A statistically significant decrease in macular GCL thickness was found in both hemiretinas of both eyes of stroke patients when compared with controls (p < 0.05). This study shows that TRD may play a role in the physiopathology of lesions of the posterior visual pathway. ARTICLE HISTORY

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“…Retinal ganglion cell (RGC) layer thinning occurs earlier than retinal nerve fibre layer (RNFL) thinning after acute optic neuropathies, and quantification of the macular RGC layer thickness may provide more valuable information on neuronal damage than RNFL thickness does [29]. Toxic optic neuropathies are primarily due to injury of the RGC layer [30]. This suggests that ganglion cell toxicity plays an important role in the development of toxic optic neuropathy.…”

Section: Discussionmentioning

confidence: 99%

Choroidal thickness, ganglion cell complex, and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

Bölükbaşı

Gürsel

Çakir

et al. 2019

Preprint

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Background To evaluate choroidal thickness, ganglion cell complex (GCC) and photoreceptor outer segment length were measured in patients with breast cancer undergoing tamoxifen therapy, using spectral-domain optical coherence tomography (SD-OCT); results were compared with those for normal eyes. Methods Forty-four patients with breast cancer, undergoing tamoxifen therapy, and 41 healthy controls were included in this prospective, comparative study. All participants underwent a complete ophthalmologic evaluation and SD-OCT. Subfoveal, nasal (nasal distance to fovea 500, 1000, 1500 μm), and temporal (temporal distance to fovea 500, 1000, 1500 μm) choroidal thickness measurements were performed using the enhanced depth imaging mode of SD-OCT. Using an Early Treatment Diagnostic Retinopathy Study (ETDRS) circle at the macular level, the automated retinal segmentation software was applied to determine the thickness of the GCC. The photoreceptor outer segment (PROS) length was determined manually, as the distance from the inner surface of the ellipsoid zone to the inner surface of retina pigment epithelium. Results The mean choroidal thickness was statistically greater in the tamoxifen group than controls in all quadrants ( p < 0.001 for all quadrants). Of all tamoxifen users (44 eyes of 44 patients), 33 eyes (75%) had UCP. Pachychoroid pigment epitheliopathy (PPE) was detected in five tamoxifen-group patients (11.3%). Patients with PPE in one eye had UCP in the fellow eye. Central serous chorioretinopathy findings were observed in one patient. Tamoxifen users had statistically lower GCC thickness in all inner rings of the ETDRS inlay and in the nasal outer ring only ( p = 0.027, 0.002, 0.002, 0.001, and 0.030, respectively). No statistically significant difference in mean subfoveal PROS length was found between the groups. Conclusions SD-OCT provides valuable information for identifying structural changes and evaluating ocular findings in patients receiving tamoxifen therapy. Increased choroidal thickness, PPE and thinning GCC were detected in tamoxifen users. These OCT findings may be an early indicator of retinal toxicity for patients undergoing tamoxifen therapy in the follow-up period. Keywords tamoxifen retinopathy, choroidal thickness, ganglion cell complex, PROS, spectral-domain optical coherence tomography

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Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Abstract: Decreased RGL thickness and volume detected in this study support a mechanism of RGL toxicity. RGL analysis may contribute to the diagnosis and management of toxic and nutritional optic neuropathies.

Cited by 36 publications

References 27 publications

Ganglion Cell Layer and Inner Plexiform Layer as Predictors of Vision Recovery in Ethambutol-Induced Optic Neuropathy: A Longitudinal OCT Analysis

Ganglion Cell Layer and Inner Plexiform Layer as Predictors of Vision Recovery in Ethambutol-Induced Optic Neuropathy: A Longitudinal OCT Analysis

Macular Ganglion Cell Layer and Peripapillary Retinal Nerve Fibre Layer Thickness in Patients with Unilateral Posterior Cerebral Artery Ischaemic Lesion: An Optical Coherence Tomography Study

Choroidal thickness, ganglion cell complex, and photoreceptor outer segment length evaluation in patients receiving tamoxifen therapy by spectral domain optical coherence tomography

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