Retinal microvasculature and optic disc alterations in non-pathological high myopia with optical coherence tomography angiography

Yaprak, Aslı Çetinkaya; Yaprak, Lütfiye

doi:10.1007/s00417-021-05216-x

Cited by 24 publications

(18 citation statements)

References 24 publications

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“…Some limitations existed in our study. First, similar to some other studies [13,34,35], magnification effects have not been corrected in our study and the actual values may be affected. According to the Littman and the modified Bennett formulae which has been adopted frequently to correct magnification effects in myopia-related studies, the actual area in vessel density measurement seemed to be smaller and closer to the fovea and the FAZ area seemed to be larger when they were compared to the original data, especially in moderate and HM [14,36].…”

Section: Discussionmentioning

confidence: 57%

“…Whether pathological myopia was included was not illustrated in He et al [30] or Qu et al [31] study. Yaprak and Yaprak [13] compared HM and control eyes, and both the RPCP density and RNFL thickness were significantly reduced in the HM group. The HM subjects in Yaprak’s study were all non-pathological.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, different imaging analysis methods have been used in previous studies, which may also contribute to the discrepancies [11, 12]. Currently, the number of studies assessing the retinal microvasculature of myopic eyes using OCTA is relatively small, and the conclusions are inconsistent [13, 14]. In addition, the peripapillary zone has seldom been evaluated in previous studies, while both the macular zone and the peripapillary area were analyzed in our study.…”

Section: Introductionmentioning

confidence: 95%

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The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

Yao

Xin

2022

Ophthalmic Res

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Objectives: To investigate the relationship between myopic severity and the retinal microvasculature based on quantitative variables using optical coherence tomography angiography (OCTA) and to identify OCTA indicators of microvascular network loss in myopia. Methods: This cross-sectional study included 123 eyes of 123 myopic subjects. The included eyes were divided into three groups according to the spherical equivalent (SE) and axial length (AL): low myopia (LM) (−3.00 D ≤ SE ≤ −0.50 D), moderate myopia (MM) (−6.00 D ≤ SE <−3.00 D) and high myopia (HM) (−9.00 D ≤ SE < −6.00 D or AL > 26 mm). All the eyes underwent OCTA scans. The densities and thicknesses of the macular and peripapillary zones, including the foveal avascular zone (FAZ) area, superficial vascular plexus (SVP) density, deep vascular plexus (DVP) density, ganglion cell complex (GCC) thickness, full retinal thickness, radial peripapillary capillary plexus (RPCP) density and retinal nerve fibre layer (RNFL) thickness, were automatically exported. Results: Compared to the LM or MM group, the HM group had a significantly reduced FAZ area (p < 0.05). In most sectors of the parafoveal and perifoveal areas, the HM group had significantly lower DVP density and higher retinal thickness than the LM and MM groups (all p < 0.05). However, significant differences among the three groups in only one or several sectors were observed with regard to SVP density, GCC thickness and RNFL thickness, and no significant differences among the three groups in any sector were noticed in RPCP density. Perifoveal DVP density and perifoveal full retinal thickness were positively associated with SE and negatively associated with AL in stepwise multiple linear regression analyses adjusted for sex and age. Conclusion: DVP density was closely related to myopic severity. Reduced perifoveal DVP density may serve as an indicator of microvascular network loss in myopia. OCTA may provide useful and crucial information for monitoring the progression of myopia.

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Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

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The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

Yao

Xin

2022

Ophthalmic Res

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“…(9)(10)(11) There are a series of retinal and choroidal complications surrounding the ONH, such as choroid neovascularization, optic disc tilted and rotation, and the parapapillary temporal crescent of chorioretinal atrophy. (12)(13)(14) Anisometropia is also associated with alterations in ONH morphology. (6, 15, 16) Serious anisometropia is always parallel with abnormal ocular development, leading to retinal and choroidal disorders, such as optic nerve hypoplasia (17) and unilateral extensive myelination.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the peripapillary structure and vasculature in patients with myopic anisometropia

Qiao

Cheng

Ruan

et al. 2022

Preprint

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Background To evaluate the interocular differences of the peripapillary structural and vascular parameters and that of association with axial length (AL) in participants with myopic anisometropia using swept-source optical coherence tomography (SS-OCT). Methods This prospective cross-sectional study included 88 eyes of 44 participants. Eyes were classified into the longer and the shorter eye group according to ALs. The β- and γ-parapapillary atrophy (PPA) areas, Bruch’s membrane opening distance (BMOD), border length (BL), and border tissue angle (BTA) were measured manually. MATLAB software determined peripapillary choroidal vascularity index (CVI) and choroidal thickness (CT) values in superior, nasal, inferior, and temporal. Results The interocular difference in spherical equivalent (SE) was highly correlated with that of the AL. The β- and γ-PPA areas, BMOD, and BL were greater in longer eyes. The mean and inferior peripapillary CVI and the mean, superior, and inferior peripapillary CT were lower in the longer eye group. The interocular difference in AL was significantly positively correlated with the γ-PPA area and BL and negatively correlated with the temporal CVI and mean, inferior, and temporal peripapillary CT. There was an independent correlation between the interocular differences in AL and the γ-PPA area, inferior and temporal peripapillary CT. Conclusions Significant differences between both groups were detected in most peripapillary parameters. The γ-PPA area, BL, and peripapillary CVI and CT were sensitively affected by the elongation of AL. The characteristics of peripapillary parameters may be useful in the prediction of AL elongation.

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“…Optical coherence tomography angiography (OCTA) is a relatively new non-invasive and time-efficient imaging technique that provides visualization of perfused vasculature of the choroid and retina [ 3 ]. With the use of OCTA software, various measurements, such as vessel density (VD) of the superficial and deep capillary plexuses (SCP and DCP), foveal avascular zone (FAZ), outer retina and choriocapillaris flow areas, subfoveal central macular thickness (CMT) and choroidal thickness can be evaluated easily [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography

Yaprak¹,

Yaprak²

2021

Cureus

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Introduction Being underweight (body-mass index < 18.50 kg/m 2 ) is associated with significantly higher morbidity than having normal weight. We aimed to investigate the changes in choroid and retinal capillary microcirculation with optical coherence tomography angiography in underweight female subjects compared with an age- and sex-matched population of healthy subjects. Methods This prospective, cross-sectional study included 48 eyes of 48 healthy female subjects, of whom 23 were underweight and 25 had normal weight. Optical coherence tomography angiography was used for the evaluation of retinal vessel density, foveal avascular zone, subfoveal central macular thickness, subfoveal choroidal thickness, and choriocapillaris flow area. Results The mean choriocapillaris flow area was statistically significantly higher in the underweight group (2.201 ± 0.11 mm 2 ) compared to the control group (2.111 ± 0.11 mm 2 ) (p=0.005). The subfoveal choroidal thickness was higher in the underweight group (340 ± 61.2 µm) compared to the control group (317 ± 20.8 µm) but the difference was not statistically significant (p=0.099). Similarly, no statistically significant difference was determined between the groups concerning the vessel density, subfoveal central macular thickness, and foveal avascular zone. Conclusions Being underweight is associated with a higher subfoveal choroidal thickness and choriocapillaris flow area, independent of additional factors, such as age, axial length, intraocular pressure, and major ocular diseases.

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Retinal microvasculature and optic disc alterations in non-pathological high myopia with optical coherence tomography angiography

Cited by 24 publications

References 24 publications

The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

The Deep Vascular Plexus Density Is Closely Related to Myopic Severity

Characteristics of the peripapillary structure and vasculature in patients with myopic anisometropia

Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography

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