Retinal neovascularization and its regression on doxycycline in epidemic retinitis

Reddy, S. Rama; Agarwal, Komal; Agarwal, Hitesh; Janis, Amelia

doi:10.4103/ijo.ijo_802_20

Indian J Ophthalmol

2020

DOI: 10.4103/ijo.ijo_802_20

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Retinal neovascularization and its regression on doxycycline in epidemic retinitis

S. Rama Reddy

Komal Agarwal

Hitesh Agarwal

et al.

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Cited by 5 publications

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“…One would opt for anti-VEGF in the presence of retinal neovascularization, but very recently regression of neovascularization with mere oral doxycycline has also been reported. 5 Thus, use of anti-VEGF for severe macular edema or even for early retinal neovascularization without vitreous hemorrhages may not be always required in epidemic retinitis. To critically evaluate the role of anti-VEGF in epidemic retinitis, larger randomized controlled trials are needed.…”

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confidence: 99%

Response to ‘Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis’

et al. 2021

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mentioning

confidence: 99%

Response to ‘Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis’

et al. 2021

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Treatment Outcomes of Presumed Rickettsial Retinitis: Evidence from OCTA Based Quantitative Analysis

Baharani¹,

Reddy

2023

Ocular Immunology and Inflammation

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Epidemic retinitis - Factors associated with poor visual outcomes

Kawali

Sanjay²,

Mahendradas³

et al. 2022

Indian Journal of Ophthalmology

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Purpose: To identify factors other than macular edema and retinitis location responsible for poor visual outcomes in epidemic retinitis (ER). Methods: A retrospective, observational, comparative study. Eyes with corrected distant visual acuity (CDVA) 20/200 or worse at resolution formed Group A. Eyes with central macular thickness (CMT) 600 μm or worse and retinitis within 1500 μm to foveal center at the presentation, but improved to CDVA 20/200 or better at the resolution formed Group B. The patient’s history, clinical presentation, imaging, and treatment outcomes were studied and the factors responsible for the final visual outcomes were compared in both groups. Results: Groups A and B included 25 eyes each. The mean CDVA at the presentation was 20/400 (range: 20/125–20000) and 20/320 (range: 20/80–20000), and mean CMT at the presentation was 948.5 μm (range: 520–1553) and 912.2 μm (range: 615–1250) in Groups A and B, respectively. All eyes except 1 (Group A) had retinitis lesions within 1500 μm of foveal center. The mean CDVA at the resolution was 20/400 (range: 20/200–20/20000) and 20/40 (range: 20/20–20/80) in Groups A and B, respectively. Older age, male gender, diabetic status, delayed presentation, poor presenting CDVA, bilaterality, presence of keratic precipitates, disk pallor, retinal thinning, and subfoveal deposits had a statistically significant association, whereas the absence of skin rash, ellipsoid zone loss, negative WIDAL, Weil-Felix test, and delayed doxycycline therapy or use of steroids without doxycycline had a statistically insignificant association with poor visual outcomes. Conclusion: Apart from presenting CMT and location of retinitis, multiple demographic, clinical, and imaging factors can be implicated for poor visual outcomes.

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Retinal neovascularization and its regression on doxycycline in epidemic retinitis

Cited by 5 publications

References 6 publications

Response to ‘Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis’

Response to ‘Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis’

Treatment Outcomes of Presumed Rickettsial Retinitis: Evidence from OCTA Based Quantitative Analysis

Epidemic retinitis - Factors associated with poor visual outcomes

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