Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography

Leung, Christopher Kai-Shun; Cheung, Carol Y.; Weinreb, Robert N.; Qiu, Quanliang; Liu, Shu; Li, Haitao; Xu, Guihua; Fan, Ning; Huang, Lijie; Pang, Chi‐Pui; Lam, Dennis Shun Chiu

doi:10.1016/j.ophtha.2009.04.013

Cited by 467 publications

(276 citation statements)

References 15 publications

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“…In this study, significant correlation was found between visual field parameter pattern standard deviation and mean RNFL thickness in the normal hemifield, using time-domain and SD-OCT [17]. Despite higher resolution and faster scanning speed of SD-OCT, the strength of structure-function association is no different from time-domain OCT [5,17].…”

Section: Discussionmentioning

confidence: 61%

“…It has been shown that RNFL measurements with Cirrus SD-OCT and Topcon 3D OCT-1000 are lower than with Stratus time-domain OCT, indicating that these instruments should not be used interchangeably [4][5][6]. Direct comparison of RNFL thickness with other studies is difficult, because of different study populations, the criteria used for classifying healthy and glaucoma, and instruments with different thickness measurement algorithms.…”

Section: Discussionmentioning

confidence: 99%

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Correlation between nerve fibre layer thickness measured with spectral domain OCT and visual field in patients with different stages of glaucoma

Cvenkel

Kontestabile

2010

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Correlation between nerve fibre layer thickness measured with spectral domain OCT and visual field in patients with different stages of glaucoma

Cvenkel

Kontestabile

2010

Graefes Arch Clin Exp Ophthalmol

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“…The Cirrus HD-OCT used in this study is a commercially available device with a scan speed of 27,000 axial scans per second and an axial resolution of 5 µm [11]. After pupil dilation using tropicamide 1% and phenylephrine hydrochloride 2.5%, Cirrus HD-OCT was used to acquire 1 macular scan using the macular cube 512 × 128 scan protocol in each study eye.…”

Section: Methodsmentioning

confidence: 99%

Reproducibility and Repeatability of Ganglion Cell-Inner Plexiform Layer Thickness Measurements in Healthy Subjects

et al. 2014

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Purpose: To assess the reproducibility and repeatability of macular ganglion cell-inner plexiform layer (GC-IPL) thickness measurements in healthy subjects. Procedures: In this observational study, 60 healthy eyes were subjected to macular GC-IPL thickness measurements by means of Cirrus™ high-definition optical coherence tomography (Cirrus version 6.0; Carl Zeiss Meditec, Dublin, Calif., USA) by two examiners in two sessions. Average, minimum and 6 sectoral GC-IPL thicknesses were measured. Inter- and intraobserver reproducibility was tested and analyzed by means of the concordance correlation coefficient (CCC). The repeatability of measurements was assessed by the coefficient of repeatability (CR). Results: Mean age (±SD) was 29.63 (±5.1) years. The CRs for average GC-IPL thickness were 2.1 and 2.2 µm for the first and the second operator, respectively. Inter- and intraobserver CCCs ranged from 0.91 (95% CI: 0.89-0.93) to 0.98 (95% CI: 0.96-0.99) and from 0.92 (95% CI: 0.88-0.94) to 0.98 (95% CI: 0.97-0.99), respectively. Conclusions: GC-IPL thickness measurements in young healthy subjects showed excellent reproducibility and repeatability, especially for average and sectoral GC-IPL thickness measurements.

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“…38,39 The Stratus OCT has a rather poor performance in preperimetric glaucoma. 40,41 Differences in the RNFL configuration and thickness assessed by OCT were detected in eyes with OHT.…”

Section: 15mentioning

confidence: 99%

Imaging Technologies for the Diagnosis of Glaucoma

Bochmann¹,

Azuara‐Blanco²

2009

European Ophthalmic Review

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In this article we describe recent advances in imaging technologies that quantify the topography of the optic nerve head and retinal nerve fibre layer and their role in diagnosing glaucoma. These technologies include optical coherence tomography (OCT), scanning laser polarimetry (SLP, GDx) and confocal scanning laser ophthalmoscopy (CSLO, HRT). A review of recently published literature was carried out.The diagnostic performance of the different imaging devices is comparable and appears to be acceptable for the diagnosis of manifest glaucoma. The benefits of recent technological improvements need to be fully assessed. At the moment it is not clear which of the currently used imaging technologies is the most useful for diagnosis and management of glaucoma. KeywordsOptical coherence tomography, scanning laser polarimetrey, confocal scanning laser ophthalmoscopy ) and optical coherence tomography (OCT) (see Figure 1). They can be used to detect early structural damage by focusing on glaucoma-relevant structures of the ONH and surrounding tissues and using a normative database to determine the probability of glaucoma. Imaging of the ONH and the RNFL for detecting glaucoma progression is another important aspect of glaucoma management. However, in this review we will focus only on the role of imaging technologies in the diagnosis of glaucoma.We will provide a brief description of the recent advances, and review the current literature on the diagnostic performance for glaucoma of these imaging devices. Scanning Laser PolarimetrySLP is designed to provide objective assessment of the RNFL thickness with potential use for diagnosis and follow-up. SLP is based on the principle that polarised light passing through the birefringence RNFL undergoes a detectable phase shift, which is linearly related to RNFL thickness. 7 The result is a 2D map of retardation around the optic disc. The software provides a discriminating classifier of glaucoma/normality named nerve fibre indicator (NFI), which is fully automated. To detect change over time, regression analysis can be performed.The first GDx nerve fibre analyser contained a fixed compensating device to compensate for polarisation effects of cornea and lens.

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Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography

Cited by 467 publications

References 15 publications

Correlation between nerve fibre layer thickness measured with spectral domain OCT and visual field in patients with different stages of glaucoma

Correlation between nerve fibre layer thickness measured with spectral domain OCT and visual field in patients with different stages of glaucoma

Reproducibility and Repeatability of Ganglion Cell-Inner Plexiform Layer Thickness Measurements in Healthy Subjects

Imaging Technologies for the Diagnosis of Glaucoma

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