Retinal Nerve Fiber Layer Thickness is Associated with Episodic Memory Deficit in Mild Cognitive Impairment Patients

Shen, Yuan; Liu, Liang; Cheng, Yan; Feng, Wei; Shi, Zhenwei; Zhu, Yikang; Wu, Wei; Li, Chunbo

doi:10.2174/1567205011666140131114418

Cited by 42 publications

(64 citation statements)

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“…A recent study has found significant reduction of RNFL thickness in AD patients compared to healthy individuals (14). The result of a current study suggested that RNFL could serve as a biomarker of mild cognitive impairment and AD (15).…”

Section: Discussionsupporting

confidence: 58%

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Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

Güneş¹,

Demirci²,

Tök³

et al. 2015

Turk J Med Sci

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Background/aim: To evaluate the retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) and to compare the results with those of healthy controls.Materials and methods: Forty patients (mean age: 75.02 ± 6.34 years; 23 women) with untreated AD and 40 age-, sex-, and educationmatched healthy patients were examined in this case-control prospective study. All patients underwent detailed ophthalmic and neurological examination. The Mini Mental State Examination (MMSE) was performed and RNFL thickness was measured using spectral-domain optical coherence tomography. The association between RNFL and MMSE score was also assessed. Results:The average RNFL thickness was 84 ± 7.0 µm in AD patients and 107 ± 6.3 µm in healthy subjects (P < 0.001). The mean MMSE score was 21.9 ± 2.13 in AD patients. There was no significant correlation between the RNFL thickness and MMSE score. Conclusion:Patients with AD had reduced RNFL thickness in all quadrants compared with the control group. This finding suggests that RNFL thickness analysis may be useful in the early diagnosis of AD.

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Section: Discussionsupporting

confidence: 58%

“…Recent OCT studies have described a loss of the RNFL thickness in patients with AD (9)(10)(11)(12)(13)(14)(15).…”

mentioning

confidence: 99%

Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

Güneş¹,

Demirci²,

Tök³

et al. 2015

Turk J Med Sci

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“…Other studies have shown a significant correlation between RNFL thickness and MMSE scores in patients with MCI and AD 86 and RNFL thickness has been significantly associated with other cognitive domains including reaction times. 87 However, the findings are not universal: both an inverse association 88 and no association 89 between RNFL and cognitive test scores have been reported. A large-scale population-based study 90 showed that better cognitive performance was significantly associated with a thicker RNFL (r 2 = 0.028, P = 0.03) in healthy young individuals without any cognitive impairment, but there were no significant associations found in older participants.…”

Section: The Rnfl In Admentioning

confidence: 97%

How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis?

Jones-Odeh

Hammond

2015

Eye

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Glaucoma is a neurodegenerative disorder with established relationships with ocular structures such as the retinal nerve fibre layer (RNFL) and the ganglion cell layer (GCL). Ocular imaging techniques such as optical coherence tomography (OCT) allow for quantitative measurement of these structures. OCT has been used in the monitoring of glaucoma, as well as investigating other neurodegenerative conditions such as Alzheimer's disease (AD) and multiple sclerosis (MS). In this review, we highlight the association between these disorders and ocular structures (RNFL and GCL), examining their usefulness as biomarkers of neurodegeneration. The average RNFL thickness loss in patients with AD is 11 μm, and 7 μm in MS patients. Most of the studies investigating these changes are cross-sectional. Further longitudinal studies are required to assess sensitivity and specificity of these potential ocular biomarkers to neurodegenerative disease progression. Eye (2015Eye ( ) 29, 1270Eye ( -1284 doi:10.1038/eye.2015; published online 4 September 2015 IntroductionGlaucoma is a neurodegenerative optic neuropathy manifesting with progressive retinal ganglion cell (RGC) and axonal loss, which can result in visual field defects and blindness because of permanent cellular and neuronal damage. Subjective clinical examination of the optic nerve head (ONH) allows for assessment and monitoring of the structural changes associated with glaucoma. However, objective detection of defects in the peripapillary retinal nerve fibre layer (RNFL) by ophthalmoscopy is difficult. The relationship between glaucoma progression and the structural changes observed at the ONH, RGC layer, and RNFL in glaucoma is well established. [1][2][3][4] Early diagnosis and treatment of glaucoma is vital to maintain visual field, as loss of RGCs is irreversible, 5 and even before any detectable visual field defects, there is a substantial loss of RGCs. Morphological abnormalities can develop 3-5 years before any functional loss is detected. 6 Since the introduction of ocular imaging techniques such as optical coherence tomography (OCT), peripapillary RNFL thickness measurements have been used for the detection and monitoring of glaucoma. 7,8 However, the use of OCT has extended beyond RNFL measurements for glaucoma, and has also been used in the investigation of other neurodegenerative disorders such as Alzheimer's disease (AD) 9-11 and multiple sclerosis (MS). [12][13][14] In addition, given the similarities of brain and retinal foetal angiogenesis, 15,16 retinal microvasculature has also been investigated as a biomarker of changes in cerebral vasculature and cognitive decline. [17][18][19] In this review, we examine the relationships between glaucoma, neurodegenerative disease, and cognitive impairment, and the use of RNFL thickness and RGC loss as potential ocular biomarkers for neurodegenerative disorders such as AD and MS. We review the strength of associations between RNFL and RGC and Eye (2015Eye ( ) 29, 1270Eye ( -1284Eye ( © 2015 Macmillan Publis...

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“…Several studies have used OCT to examine the RNFL in subjects with a clinical diagnosis of MCI [17–26]. Ascaso et al.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis

Knoll

Simonett

Volpe

et al. 2016

Alz & Dem Diag Ass & Dis Mo

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IntroductionRetinal structural changes in subjects with mild cognitive impairment (MCI) remain a subject of controversy.MethodsWe investigated the correlation between optical coherence tomography (OCT) of the retinal sublayers, including the retinal nerve fiber layer (RNFL), and cognitive function in subjects with amnestic MCI and compared the OCT findings with matched controls. We also performed a meta-analysis of the world literature using a random-effects model.ResultsWe found no statistically significant differences in OCT between amnestic MCI (aMCI) and controls. In aMCI subjects, we found an inverse relationship between RNFL thickness and two cognitive tests (delayed story recall and a word-list learning test and the word-list test). The meta-analysis revealed a statistically significant decrease in RNFL thickness in MCI subjects.DiscussionThe inverse relationship between cognitive testing and RNFL thickness suggests that retinal involvement may include paradoxically increased thickness of the RNFL, which could suggest gliotic reactive changes.

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Retinal Nerve Fiber Layer Thickness is Associated with Episodic Memory Deficit in Mild Cognitive Impairment Patients

Cited by 42 publications

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Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

Evaluation of retinal nerve fiber layer thickness in Alzheimer disease usingspectral-domain optical coherence tomography

How strong is the relationship between glaucoma, the retinal nerve fibre layer, and neurodegenerative diseases such as Alzheimer’s disease and multiple sclerosis?

Retinal nerve fiber layer thickness in amnestic mild cognitive impairment: Case‐control study and meta‐analysis

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