Retinal Nerve Fiber Layer Thickness in Normals Measured by Spectral Domain OCT

Bendschneider, D; Tornow, Ralf P.; Horn, Folkert K.; Laemmer, Robert; Roessler, C. W.; Juenemann, Anselm; Kruse, Friedrich E.; Mardin, Christian Y.

doi:10.1097/ijg.0b013e3181c4b0c7

Cited by 184 publications

(159 citation statements)

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“…Refractive error and age at examination are some of the well-known confounding factors in the interpretation of peripapillary RNFL thickness. [32][33][34][35][36][37][38] In addition, we performed correlation analysis between various baseline factors and peripapillary RNFL thicknesses in multiple sectors separately. As there was a difference in the pattern of RNFL distribution according to different sectors, it would be more accurate to analyze RNFL thickness in each sector separately.…”

Section: Variablementioning

confidence: 99%

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

2015

Eye

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Purpose To compare retinal nerve fiber layer (RNFL) thickness profiles between preterm and full-term children and to investigate factors affecting the RNFL distribution in preterm children.Methods We performed Spectral domain optical coherence tomography (SD-OCT) peripapillary RNFL circular scan centered on the optic disc in 50 premature and 58 full-term children. RNFL thickness profiles were compared between preterm and fullterm children using a linear regression model. Among preterm patients in this study, 20 patients previously received laser treatment for severe retinopathy of prematurity (ROP).Results Global average, nasal, and superior disc RNFL thickness profiles were significantly smaller in preterm children (92.70 ± 16.57 μm, 56.02 ± 17.04 μm, and 108.74 ± 27.36 μm, respectively) compared with full-term children (101.63 ± 9.21 μm, P = 0.006, 69.14 ± 14.15 μm, Po0.001, and superior, 129.11 ± 18.14 μm, Po0.001, respectively). Multivariable analysis revealed that ROP stage was inversely correlated with nasal RNFL thickness (P = 0.010).Conclusions Our SD-OCT data demonstrate decreased global average, nasal, and superior disc RNFL thicknesses in preterm children. ROP stage was inversely correlated with nasal RNFL thickness. Further studies are needed to better understand the association between these structural changes and visual functions in preterm children.

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Section: Variablementioning

confidence: 99%

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

2015

Eye

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“…The light source of the SDOCT is a super luminescent diode with a wavelength of 870 nm. Infrared images and OCT scans (40,000 A-Scan/sec) of the dual laser scanning systems are acquired simultaneously (10) . Three consecutive circular B-scan (3.4-mm diameter, 768 A-scans) centered at the optic disc were performed in one visit by the same operator.…”

Section: Oct Measurementsmentioning

confidence: 99%

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

Toscano¹,

Ávila²,

Chalita³

2012

Arq. Bras. Oftalmol.

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Purpose: To evaluate the reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurements in normal eyes and eyes with glaucoma using spectral domain optical coherence tomography (SDOCT). Methods: One eye of 79 normal and 72 glaucoma patients was analyzed. All patients underwent a complete ophthalmological examination, including visual acuity testing; intraocular pressure, slit-lamp examination, indirect ophthalmoscopy; and the glaucoma group underwent achromatic perimetry with the 24-2 SITA Fast Humphrey Field Analyzer. All patients' eyes were scanned using the spectral domain optical coherence tomography -Spectralis ® and one of them was cho sen randomly. Three con secutive circular B-scan centered at the optic disc were performed in one visit. Results: The intraclass correlation coefficient (ICC), coefficient of variation and test-retest variability for the mean retinal nerve fiber layer thickness were respectively: 0.94, 2.56% and 4.85 µm for the normal group and 0.93, 4.65% and 6.61 µm for the glaucomatous group. The intraclass correlation coefficient for retinal nerve fiber layer thickness in all quadrants were all excellent in both groups, with the superior quadrant having the highest ICCs (0.964) in glaucomatous eyes and nasal quadrant measurements having the lowest (0.800), but still excellent in eyes without glaucoma. The coefficient of variation was between 2.56% -8.74% and between 4.65% -11.44% in normal and glaucomatous group respectively. The test-retest variability was between 4.85 µm and 11.51 µm in the normal group and between 6.61 µm and 14.24 µm in the glaucomatous group. The measurements in glaucomatous eyes were more variable than normal eyes. Conclusions: Spectral domain optical coherence tomography showed excellent reproducibility with regard to retinal nerve fiber layer thickness measurements in normal and glaucomatous eyes.Keywords: Diagnostic techniques, ophthalmological; Glaucoma/diagnosis; Tomography, optical coherence/methods; Retinal ganglion cells; Optic nerve/pathology; Nerve fibers; Reproducibility of results RESUMO Objetivo: Avaliar a reprodutibilidade da medida da espessura da camada de fibras nervosas da retina (CFNR) em olhos sem e com glaucoma utilizando-se tomografia de coerência óptica de domínio espectral (spectral domain OCT -SDOCT

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“…Budenz et al (2007) showed the decay per decade to be 2.0 microns. Similarly, Bendschneider et al (2010) reported the decrease in the RNFL thickness to be 1.90 microns per decade. Closer home, Mansooriet et al (2012) has also shown a negative correlation of the RNFL with age where the average RNFL thinning was 0.116 microns per year.…”

Section: Resultsmentioning

confidence: 99%

“…The mean thickness of the RNFL seen in our study was 102.64 μm which is comparable to the other studies done in other Asian countries (103.0 to 108.4 μm) (Choi et al, 2005;Hsu et al, 2008;Sony et al, 2004). However, the studies from western populations showed the mean RNFL thickness to be lower (85.8 -99.36 μm) than in Asian populations (Bendschneider et al, 2010;Bowd et al, 2000;Lopez-Pena et al, 2011). The differences in the RNFL thickness among Asians, coloured people and Western populations may have racial causes or may be dependent upon some physical phenomena.…”

Section: Resultsmentioning

confidence: 99%

“…RNFL thinning is also seen in myopia (Budenz et al, 2007;Hougaard et al, 2006) and in old age (Lee et al, 2000;Sony et al, 2004). RNFL thickness may show a racial variation as well (Bendschneider, 2010;Poinoosawmy et al, 1997;Repka et al, 1989;Sony et al, 2004;Tsai et al, 1995). According to Zeimer, quantitative detection of glaucomatous damage at the posterior pole by retinal thickness mapping may provide a unique method for the detection and monitoring of early glaucomatous tissue loss (Zeimer et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

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Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

et al. 2014

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Objective: To determine the normal values for peripapillary retinal nerve fibre layer thickness (RNFL) measured by spectral domain optical coherence tomography (SD-OCT) in a healthy Nepalese population and to compare the RNFL thicknesses between the genders and among the various age groups. Material and methods: One hundred and fifty six eyes of 156 healthy Nepalese subjects (66 males and 88 females) of various age groups were enrolled in this observational, cross-sectional, hospital-based study. The peripapillary RNFL of the randomly chosen eye of each subject was imaged with a high resolution SD-OCT (Spectralis HRA+OCT, Heidelberg Engineering). The RNFL thickness was measured around the optic nerve head using 16 automatically averaged, consecutive, circular B scans with a 3.4 mm diameter and compared between the genders and among the various age groups. Results: The mean age of the subjects was 38.94 ± 17.00 years (range -14 to 76 years). The average peripapillary RNFL was found to be 102.64 ± 9.56 μm (95 % CI 97.01 -101.93). The mean ± SD peripapillary RNFL measurements at the superior, nasal, inferior and temporal sectors in the study population were 129.51 ± 15.09 μm, 76.55 ± 12.02 μm, 134.53 ± 17.19 μm and 70.74 ± 15.53 μm respectively. The average RNFL thickness was 99.47 ± 10.18 μm in the male whereas it was 105.09 ± 8.31 μm in the female participants. The RNFL decreased by 2.26 μm per age perdecade. Conclusion: The Average RNFL thickness is 102.64 ± 9.56 μm in the Nepalese population. Gender and age related variation in the RNFL can serve as a useful guideline in the diagnosis of glaucoma in our population.

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Retinal Nerve Fiber Layer Thickness in Normals Measured by Spectral Domain OCT

Cited by 184 publications

References 34 publications

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

Retinal nerve fiber layer thickness in prematurity is correlated with stage of retinopathy of prematurity

Reproducibility of peripapillary retinal nerve fiber layer thickness measurements using Spectral Domain OCT in Brazilian patients

Retinal nerve fibre layer thickness in a healthy Nepalese population by spectral domain optical coherence tomography

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