Retinal nerve fiber layer thickness in Indian eyes with optical coherence tomography

Malik, Abdul Majeed; Singh, Manpreet; Arya, SK; Sood, Sunandan; Ichhpujani, Parul

doi:10.3126/nepjoph.v4i1.5852

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…Increasing age is associated with a decline in RNFL thickness. This is in keeping with findings of other studies in North America,[620] Latin America,[19] Germany,[2122] India,[121223] Iran,[24] and Japan. [13252627] Lower RNFL values in older patients may not be due to a pathological cause.…”

Section: Discussionsupporting

confidence: 92%

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Retinal nerve fiber layer thickness measurements of normal Northern Nigerian adults using optical coherence tomography

2016

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Objective:To assess retinal nerve fiber layer (RNFL) thickness measurements of normal Northern Nigerian adults using optical coherence tomography (OCT).Subjects and Methods:The OCT procedure was carried out with the Carl Zeiss Stratus OCT Model 3000 software version 4.0 (Carl Zeiss Meditec AG, Jena, Germany). The fast RNFL scan protocol was used to obtain RNFL thickness measurements. Student's t-test was used to compare mean RNFL thickness values. P ≤ 0.05 was considered as statistically significant. Average RNFL thickness was correlated with age.Results:Two hundred and twenty eyes of 110 subjects aged 18–51 years were examined. The average RNFL thickness was 104.17 ± 10.71 μm. The mean values for the RNFL thickness were 129.15 ± 16.87 μm, 135.34 ± 20.40 μm, 85.10 ± 23.60 μm, and 67.19 ± 13.27 μm for the inferior, superior, nasal, and temporal quadrants, respectively. A statistically significant difference was found between males and females for the mean RNFL thickness (t = 3.30, P = 0.001) and for the mean superior and inferior RNFL thickness. There was a statistically significant difference between right and left eyes (t = 3.73, P = 0.001) for the mean RNFL thickness. A negative correlation was found between RNFL thickness and age (r = −0.313, P = 0.002).Conclusion:Normal RNFL thickness measurements in healthy Nigerian adults are presented. The RNFL was found to be thicker in females and in right eyes. The values were comparable to those of the Indian population but higher than some Caucasian values.

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Section: Discussionsupporting

confidence: 92%

“…Average RNFL thickness of subjects in this study was found to be similar to that of Indians[121112] and Japanese. [13] Lower mean RNFL thickness values were obtained in similar studies carried out in California,[14] New England,[15] and Italy.…”

Section: Discussionsupporting

confidence: 65%

Retinal nerve fiber layer thickness measurements of normal Northern Nigerian adults using optical coherence tomography

2016

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“…The mean global RNFL thickness of Indian participants (102 µm) in this study was comparable to four studies 35,36,37,38 in India involving Indian participants (101 µm -105 µm). Furthermore, the mean RNFL thickness for Indian participants in the present study was similar to means reported in other Asian populations: 102 µm -104 µm in Japanese 39,40 and 101 µm in Asians.…”

Section: Figuresupporting

confidence: 79%

Retinal nerve fibre layer thickness of black and Indian myopic students at the University of KwaZulu-Natal

Murugan

Golodza

Pillay

et al. 2015

African Vision and Eye Health

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Aim: To compare retinal nerve fibre layer (RNFL) thickness in black and Indian myopic students at the University of KwaZulu-Natal.Method: Eighty (40 black and 40 Indian) participants of both genders and aged between 19 and 24 years (mean and standard deviation: 21 ± 1.7 years) were included in the study. Refractive errors were assessed with the Nidek AR-310A auto-refractor and via subjective refraction. RNFL thicknesses were then measured using the iVue-100 optical coherence tomography device. Axial lengths were measured with the Nidek US-500 A-scan ultrasound device. Data were analysed by descriptive statistics, t-tests, Pearson’s correlation coefficients and regression analysis.Results: The mean myopic spherical equivalent was significantly more negative amongst the Indian (-2.42 D ± 2.22 D) than amongst the black (-1.48 D ± 1.13 D) (p = 0.02) participants.The mean axial length was greater amongst the black (23.35 mm ± 0.74 mm) than amongst the Indian (23.18 mm ± 0.87 mm) participants but the difference was not significant. In the total sample (n = 80), the average global RNFL thickness ranged from 87 μm to 123 μm (105 μm ±9 μm). Mean global RNFL thickness was slightly greater amongst black (108 μm ± 7 μm) than amongst Indian (102 μm ± 9 μm) (p = 0.00) participants. Mean global RNFL thickness was similar for male (106 μm ± 7 μm) and female (105 μm ± 10 μm) (p = 0.79) participants.A positive and significant association between myopic spherical equivalent and global RNFL thickness was found for the total sample (r = 0.36, p = 0.00) and for Indians (r = 0.33, p = 0.04)but not for the black (r = 0.25, p = 0.13) participants. There was a negative and significant correlation between axial length and global RNFL thickness amongst the Indian participants (r = -0.34, p = 0.03) but not amongst the total sample (r = -0.12, p = 0.30) or the black (r = 0.06, p = 0.73) participants.Conclusion: The findings suggest that racial differences in RNFL thickness need to be considered in the clinical examination and screening for glaucoma and other optic nerve pathologies amongst black and Indian people. Additionally, the possible influences ofrefractive error and axial length should be considered when evaluating RNFL thickness.

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“…The ganglion cells-inner plexiform layer thickness is reduced with age. 30,52 Our observation that there is an overall decrease in ganglion cell complex thickness with age in diabetes [27][28][29] could represent a similar phenomenon and this effect of aging may be accelerated in diabetes.…”

Section: Likely Pathogenesismentioning

confidence: 73%

“…For instance, inner retinal thickness is reported to be inversely correlated with prolonged duration of diabetes 14 and higher glycaemic levels, 24 while both are related to the development and progression of neuropathy 25 and retinopathy. 26 In individuals without diabetes, retinal nerve fibre layer 27,28 and ganglion cell complex 29,30 thicknesses are reduced with higher axial lengths, 27,30 in Hispanic and Caucasian adult eyes compared to Asian adult eyes 27 and in females compared to males. 30 Our study took into account a number of potentially confounding factors, namely, diabetic retinopathy, age, sex, type of diabetes, duration of diabetes and HbA 1c levels.…”

mentioning

confidence: 99%

Focal loss volume of ganglion cell complex in diabetic neuropathy

Srinivasan

Pritchard

Sampson

et al. 2016

Clinical and Experimental Optometry

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Retinal nerve fiber layer thickness in Indian eyes with optical coherence tomography

Abstract: Introduction: Measuring the thickness of the retinal nerve fiber layer is a potential method of recognizing axon loss prior to the visual field abnormality.

Cited by 9 publications

References 11 publications

Retinal nerve fiber layer thickness measurements of normal Northern Nigerian adults using optical coherence tomography

Retinal nerve fiber layer thickness measurements of normal Northern Nigerian adults using optical coherence tomography

Retinal nerve fibre layer thickness of black and Indian myopic students at the University of KwaZulu-Natal

Focal loss volume of ganglion cell complex in diabetic neuropathy

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