Retinal Nerve Fiber Layer Thickness in Children With ADHD

Hergüner, Arzu; Alpfidan, İsmail; Yar, Ahmet; Erdoğan, Erkan; Metin, Özge; Sakarya, Yaşar; Hergüner, Sabri̇

doi:10.1177/1087054716664412

Cited by 24 publications

(40 citation statements)

References 40 publications

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“…Herguner et al have compared the RNFL thickness measurement results of 45 ADHD diagnosed children with a healthy group of 45 children; and they have found the RNFL thickness in the nasal quadrant of the ADHD diagnosed children to be significantly lower than the control group. Moreover, they have reported a negative correlation between the severeness of the symptoms and the RNFL thickness (27). In our study, although a thinning in the left and right eye average RNFL thickness detected in the patient group, it was not statistically significant.…”

Section: Discussioncontrasting

confidence: 77%

Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder (eng)

Bodur¹,

Açıkel²,

Yaşar³

2018

J Clin Psy

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Section: Discussioncontrasting

confidence: 77%

Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder (eng)

Bodur¹,

Açıkel²,

Yaşar³

2018

J Clin Psy

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“…Hergüner et al found that the ADHD group's macular thickness did not differ from age-matched controls, but the RNFL is reduced in the ADHD group. They also suggested that there was a negative correlation between RNFL thickness and ADHD symptom severity [20]. In parallel with the previous result, we found RNFL thickness was lower in the ADHD group than in the control group, but this difference was not statistically significant.…”

Section: Discussionsupporting

confidence: 89%

“…To the best of our knowledge, there are only two studies evaluated the RNFL and macular thickness of eyes of children and adolescents with ADHD which is a neurodevelopmental disorder. Hergüner et al found that the ADHD group's macular thickness did not differ from age-matched controls, but the RNFL thickness is reduced in the ADHD group [20]. In another study, children and adolescents with ADHD and Oppositional Defiant Disorder (ODD) accompanying ADHD compared to healthy controls, no significant difference was found in terms of RNFL but the ganglion cell layer of the retina was found to be thinner in ADHD and ADHD + ODD groups [21].…”

Section: Introductionmentioning

confidence: 96%

“…As a result of a meta-analysis of case-control studies related to this issue and performed in 2018, it was stated that RNFL can be used as a diagnostic tool in schizophrenia [16]. In addition to studies about schizophrenia, there are researches that ocular findings have been evaluated by using OCT in patients with Major depressive disorder, ADHD and Anorexia nervosa [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

Ayyıldız

2019

Psychiatry and Clinical Psychopharmacology

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AIM: We aimed to explore whether there is difference in terms of Retinal Nerve Fiber Layer (RNFL) thickness, macula thickness and anterior segment structures of the eye between children and adolescents with ADHD and healthy controls. METHOD: Children and adolescents aged 8-16 years who were admitted to the Child Psychiatry outpatient clinic of Ahi Evran University Hospital diagnosed with ADHD constituted the study group. Exclusion criteria included patients who had any systemic/ocular or psychiatric disorder other than ADHD and patients who had any psychopharmacological treatment. Participants in the control group were children and adolescents who applied to the outpatient clinic of Ophthalmology at the same hospital with no chronic medical or psychiatric disorder. Groups were compared in terms of central macular thickness, retinal nerve fibre layer thickness (RNFL), central corneal thickness, corneal diameter, mean corneal radius of curvature, anterior chamber depth, and axial length using Optical Coherence Tomography (OCT) and Optical Biometry. RESULTS: Data obtained from the measurements of 60 eyes of 30 patients with ADHD and 60 eyes of 30 patients of the control group were evaluated. Groups were similar in terms of age and gender. Corneal thickness (p = 0.001) and axial length (p = 0.04) values were significantly higher in ADHD group while the mean corneal curvature radius (p = 0.03) was significantly lower in ADHD group than in controls. No significant difference was observed between groups in terms of RNFL thickness, macular thickness, the corneal diameter, and anterior chamber depth measurements. CONCLUSION: In recent years, the use of OCT in neuropsychiatric diseases has increased the interest in identifying possible biomarkers and the elucidation of neurodegenerative and neurodevelopmental mechanisms that contribute to the nature of these diseases. Differences in the ophthalmic anatomical structures observed between healthy controls and cases with ADHD, which is a neurodevelopmental disorder, need to be supported by longitudinal studies with a larger sample and using OCT in connection with brain imaging.

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“…Moreover, Iseri et al have demonstrated a relationship between retinal pathology and cognitive impairment in an AD group [14]. As for ADHD, Hergüner reported lower RNFL thickness, but no difference in macular thickness [15].…”

Section: Introductionmentioning

confidence: 99%

Pilot Study: An Ocular Biomarker for Diagnosis of Attention Deficit Hyperactivity Disorder

Bae

Kim

Han

et al. 2019

Psychiatry Investig

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Objective Biomarkers of attention deficit hyperactivity disorder (ADHD) are crucial for early diagnosis and intervention, in which the identification of biomarkers in other areas of the body that represent the immature brain of children with ADHD is necessary. The present study aimed to find biomarkers of ADHD in the retina and assessed the relationship between macular thickness of the retina and cortical thickness of the brain in children with ADHD. Methods Twelve children with ADHD and 13 control children were recruited for the study. To find ocular markers of ADHD, we investigated the correlation between clinical symptoms of ADHD assessed with the Korean ADHD Rating Scale (K-ARS), cortical thickness of the brain, and macular thickness measured with the mean thickness from the Early Treatment Diabetic Retinopathy Study (ETDRS). Results Children with ADHD showed increased macular thicknesses quantified as an ETDRS ring in both eyes, compared to control subjects. Moreover, the right inner ETDRS ring had a positive correlation with K-ARS scores. The ADHD group had an increased ratio of thickness of the right frontal lobe to that of the parietal cortex, compared with the control group. There were positive correlations between the means of the inner ETDRS ring (right) and the left paracentral/right isthmus cingulate thicknesses in the control group. However, there were negative correlations between the means of the inner ETDRS ring (right) and the left frontal pole/right pars triangularis thicknesses in the ADHD group. The results of both groups were at the uncorrected level. Conclusion The different patterns of macular thickness might represent the immature cortical thickness of the brain in children with ADHD.

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Retinal Nerve Fiber Layer Thickness in Children With ADHD

Cited by 24 publications

References 40 publications

Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder (eng)

Evaluation of the ganglion cell layer thickness in children with attention deficit hyperactivity disorder and comorbid oppositional defiant disorder (eng)

Retinal nerve fiber layer, macular thickness and anterior segment measurements in attention deficit and hyperactivity disorder

Pilot Study: An Ocular Biomarker for Diagnosis of Attention Deficit Hyperactivity Disorder

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