Retinal Nerve Fibre Layer Measurements in Normal Eyes in Zaria Using Optical Coherence Tomography

Mahmud-Ajeigbe, Fatima A; Abdulrahman, H; Rafindadi, Abdulkadir L; Abah, ER

doi:10.4103/2384-5147.157430

Cited by 4 publications

(5 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All measured values showed a significant reduction in thickness with aging. This was also in keeping with other reports on the subject [ 13 , 14 , 17 , 18 , 28 , 29 ]. Gender did not show any effect on the thickness of any measured parameter.…”

Section: Discussionsupporting

confidence: 92%

“…The RNFL values in our report were also thicker than reports from the northern part of the country [17,18]. The reports from northern Nigeria reported significant intra-eye RNFL thickness variability, which was absent in our report [17].…”

Section: Discussioncontrasting

confidence: 72%

“…Other reports using the Spectralis SD-OCT demonstrated this difference among eyes in India, Nepal, and Brazil [ 14 - 16 ]. Using the Stratus SD-OCT, Sani et al [ 17 ] and Mahmud-Ajeigbe et al [ 18 ] demonstrated that the RNFL thickness in Northern Nigerian eyes was similar to Japanese [ 19 ] measurements but thicker than the reports from Italy [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Unfortunately, these measurements are few or do not exist, especially in Nigeria. While the studies by Sani et al [ 17 ] and Mahmoud-Ajeigbe et al [ 18 ] provided RNFL values in Nigerian eyes using the Stratus SD-OCT, no other study has attempted to document the normative OCT values of Nigerians. To the best of our knowledge, this is the first study in Nigeria to provide normative values of the RNFL, GCL, and GCC of normal Nigerian eyes using the Topcon SD-OCT.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optical Coherence Tomography Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurements in Normal Southern Nigerian Eyes

Obasuyi¹,

Osuji²,

Ifijen³

et al. 2022

Cureus

View full text Add to dashboard Cite

IntroductionGlaucoma is the leading cause of irreversible blindness worldwide. It is more severe in people with African heritage, and intraocular pressure remains the only modifiable risk factor in managing glaucoma. Attempts to improve the diagnosis and monitoring of glaucoma are ongoing. One of those attempts is the development of optical coherence tomography (OCT). However, there is a theoretical possibility of a delayed or wrong diagnosis of glaucoma using the OCT because of racial, age, and sex differences in the RNFL (retina nerve fibre layer), GCL (ganglion cell layer), and GCL+IPL (ganglion cell layer and inner plexiform layer) thickness. ObjectiveThis study aims to provide the measurements of RNFL, GCL, and GCL+IPL in normal eyes of southern Nigerian patients and specifically to evaluate the relationship of these measurements to gender, age, intraeye variability, and the Topcon SD-OCT normative database. MethodThree hundred and four eyes of 152 patients who had normal OCT scans using the 6x6 RNFL (four sectors) and Macula scans of the Topcon OCT-1 3D Maestro OCT machine were included for analysis. Parametric tests were used to interrogate the relationship between normally distributed parameters and gender, age, and the Topcon reference database. Non-parametric tests were used for non-normally distributed data. ResultsThe male-to-female ratio was 1:1, and ages ranged between 18 and 71 for both genders. The average RNFL values were 111.49 ± 10.44 (right eye -RE) and 111.96 ± 9.66 (left eye -LE). For the GCL, average values were 66. 23 ± 4.4 (RE) and 66.34 ± 4.19 (LE). GCL+IPL values were 104.02 ± 6.71 (RE) and 103.89 ± 6.66 (LE). There was no difference between genders (X 2 = 56.467; df = 46; p = 0.160), and RNFL, GCL, and GCL+IPL values showed a significant reduction as the age of the respondents increased. There was a significant difference between RNFL, GCL, and GCL+IPL values and the Topcon reference database, p < 0.001. ConclusionSignificant differences exist between the Southern Nigerian eyes' RNFL, GCL, and GCL+ IPL values and the Topcon OCT-1 3D Maestro reference database. While randomised control trials and extensive multi-centre studies have not been conducted to determine the possible effects of these differences between measured values and reference databases of the OCTs, they need to be considered while diagnosing and managing glaucoma with the OCT.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Optical Coherence Tomography Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurements in Normal Southern Nigerian Eyes

Obasuyi¹,

Osuji²,

Ifijen³

et al. 2022

Cureus

View full text Add to dashboard Cite

show abstract

“…Retinal nerve fiber layer images were acquired by taking three circular 3.4 mm diameter scans, centered on the optic disc. 14 The mean of these was used to express RNFLT in four quadrants (temporal, superior, inferior, and nasal). The thicknesses of the quadrants were automatically calculated by the OCT device software.…”

Section: Methodsmentioning

confidence: 99%

<p>Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study</p>

Eslami¹,

Ghiasian²,

Khanlarzade³

et al. 2020

View full text Add to dashboard Cite

Background: Optic neuritis (ON) is an inflammatory demyelinating lesion in the optic nerve, which is strongly associated with multiple sclerosis (MS). Optical coherence tomography (OCT) is a noninvasive technique for the evaluation of the retinal layers. Our aim was to examine OCT metrics including retinal nerve fiber layer thickness (RNFLT), and total macular volume (TMV), in MS subtypes and their relationship with duration, first manifestation, and severity of disease. Material and Methods: In this cross-sectional study, patients with a definite diagnosis of MS underwent complete ophthalmic and neurologic examination. OCT parameters including TMV and RNFLT were compared between MS subtypes and different first manifestations of MS. Their relationships were also studied with the duration and severity of disease based on the Expanded Disability Status Scale (EDSS) score. Results: A total of 240 eyes were examined in 120 enrolled MS patients. The differences in RNFLT were not analytically meaningful between the subtypes of MS, but the differences in TMV values were statistically significant between the subtypes of MS (P: 0.39 and P: 0.04, respectively). The differences between RNFLT and TMV of eyes with and without ON were statistically significant between these two groups (P<0.001 and P<0.001). There was also an inverse correlation between EDSS disability score and RNFLT and TMV values (P: 0.00, r: −0.33 and P: 0.034, r: −0.11, respectively) and a significant inverse correlation between the duration of MS and RNFLT (P: 0.00, r: −0.47). The differences in RNFLT and TMV values were analytically meaningful between the categories of first manifestations of MS (P: 0.000 and P: 0.027, respectively). Conclusion: RNFLT and TMV represent noninvasive parameters for assessment of neuroaxonal degeneration in the anterior visual pathway that correlate with the severity and duration of multiple sclerosis. The lowest RNFLT and TMV values were also seen in the perceptual category between the first manifestations of MS. Therefore, they may be useful in the evaluation of MS patients.

show abstract

Retinal nerve fibre layer thickness in a normal black South African population

Ismail

Ally

Alli

2019

Eye

View full text Add to dashboard Cite

Retinal Nerve Fibre Layer Measurements in Normal Eyes in Zaria Using Optical Coherence Tomography

Cited by 4 publications

References 1 publication

Optical Coherence Tomography Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurements in Normal Southern Nigerian Eyes

Optical Coherence Tomography Retinal Nerve Fibre Layer and Ganglion Cell Complex Measurements in Normal Southern Nigerian Eyes

<p>Retinal Nerve Fiber Layer Thickness and Total Macular Volume in Multiple Sclerosis Subtypes and Their Relationship with Severity of Disease, a Cross-Sectional Study</p>

Retinal nerve fibre layer thickness in a normal black South African population

Contact Info

Product

Resources

About