Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome

Sagiv, Oded; Fishelson-Arev, Tagil; Buckman, Gila; Mathalone, Nurit; J, Wolfson; Segev, Eitan; Peled, Ron; Lavi, Idit; Geyer, Orna

doi:10.1111/ceo.12145

Cited by 41 publications

(35 citation statements)

References 24 publications

(39 reference statements)

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“…Of these 19 articles, 4 contained no useful data for meta-analysis, and 5 only investigated macular fovea thickness or choroidal thickness, and so they were not suitable for inclusion. The remaining 10 case-controlled studies were included in the final meta-analysis [6,7,8,11,17,18,19,20,21,22]. …”

Section: Resultsmentioning

confidence: 99%

“…Four studies were performed in Turkey [11,17,20,22], 3 in Spain [8,18,19], and 1 each in Taiwan [7], China [21], and Israel [6]. The mean age of the patients ranged from 40 to 67 years, and the percentage of men ranged from 40 to 95%.…”

Section: Resultsmentioning

confidence: 99%

“…Although RNFL thickness decreases with age [4], a number of studies have found that RNFL thickness is significantly decreased not only in glaucomatous neuropathy [5], but also in other neurological disorders such as the above [1,2,3]. Recent studies have reported that RNFL changes also occur in obstructive sleep apnea/hypopnea syndrome (OSAHS) [6,7]. This condition is characterized by recurrent partial or complete upper airway obstruction and a decrease in oxygen saturation during sleep.…”

Section: Introductionmentioning

confidence: 99%

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Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Mei

Feng

et al. 2016

Ophthalmic Res

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Purpose: To evaluate and compare changes in retinal nerve fiber layer (RNFL) thickness in patients with obstructive sleep apnea/hypopnea syndrome (OSAHS). Methods: The Cochrane Library, Medline, and Embase were screened using our key words. Results were carefully reviewed to ensure that the included studies met the inclusion/exclusion criteria, and the quality of the studies was assessed using the Newcastle-Ottawa Scale. All included studies categorized patients with OSAHS into 3 groups (mild, moderate, and severe), and measured average and 4-quadrant (temporal, superior, nasal, and inferior) RNFL thickness. All studies included a healthy control group. The weighted mean differences and 95% confidence intervals were calculated for the continuous outcomes. Results: Ten case-control studies were included in the meta-analysis, consisting of a total of 811 OSAHS group and 868 healthy eyes. A meta-analysis of the data showed that the average RNFL thicknesses in the mild, moderate, and severe OSAHS groups were significantly decreased compared to healthy controls. Additionally, RNFL thickness was significantly reduced in all but the temporal quadrant in the moderate and severe OSAHS groups when compared to healthy controls. Conclusions: On the basis of these results, we suggest that peripapillary RNFL thickness as measured by optical coherence tomography could be a useful tool to monitor and assess the severity of OSAHS in patients. Further studies are required in order to differentiate these RNFL changes from glaucomatous changes. This has not been properly examined in any of the studies we were able to identify.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Mei

Feng

et al. 2016

Ophthalmic Res

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“…Several studies have found that the RNFL thickness levels in patients with obstructive sleep apnea syndrome are decreased compared with control subjects. 49,50 Different polysomnography parameters are also associated with the RNFL thickness in patients with normal-tension glaucoma or normal-tension glaucoma with obstructive sleep apnea syndrome. One hypothesis is that the chronic low oxygen saturation index can damage the retinal tissue, leading to RNFL thinning.…”

Section: Discussionmentioning

confidence: 99%

Intrinsically Photosensitive Retinal Ganglion Cell Activity Is Associated with Decreased Sleep Quality in Patients with Glaucoma

Gracitelli¹,

Duque-Chica²,

Roizenblatt³

et al. 2015

Ophthalmology

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“…However, foveal thickness and total macular volume were not correlated. Sagiv et al [25] reported that the RNFL thickness is reduced in the superior and inferior quadrants of patients with advanced OSA syndrome. The reduction was less than 5.2 µm, however, which is a small difference and may be due to the variability of spectral domain OCT [25,26,27,28].…”

Section: Discussionmentioning

confidence: 99%

Macular Retinal Ganglion Cell Layer Thickness Is Not Reduced in Patients with Obstructive Sleep Apnea

et al. 2016

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Purpose: To evaluate macular ganglion cell layer (GCL) and ganglion cell-inner plexiform layer (GCIPL) thicknesses in patients with obstructive sleep apnea (OSA) syndrome. Methods: 73 OSA patients and 67 age-matched controls were consecutively and prospectively enrolled. All participants underwent at least one reliable standard automated perimetry (SAP) and were imaged with spectral-domain optical coherence tomography (OCT) using two different devices. The OCT parameters were compared between groups, and Pearson correlations between main indices of SAP and OCT parameters were calculated. Results: The pattern standard deviation of SAP was higher in the OSA group (p = 0.001). Mean GCIPL thickness was 82.99 ± 10.30 and 80.78 ± 12.15 µm in the control and OSA groups, respectively (p = 0.25), and GCL thickness was 44.93 ± 11.42 µm in the control group and 48.81 ± 10.85 µm in OSA individuals (p = 0.47). Pearson correlations between the GCIPL-GCL measurements and the main indices of SAP were not significant. Conclusions: Neither GCIPL nor GCL thickness were reduced in OSA subjects compared with healthy individuals. Retinal sensitivity evaluated with SAP was however decreased in OSA patients.

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Retinal nerve fibre layer thickness measurements by optical coherence tomography in patients with sleep apnoea syndrome

Cited by 41 publications

References 24 publications

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Changes in Retinal Nerve Fiber Layer Thickness in Obstructive Sleep Apnea/Hypopnea Syndrome: A Meta-Analysis

Intrinsically Photosensitive Retinal Ganglion Cell Activity Is Associated with Decreased Sleep Quality in Patients with Glaucoma

Macular Retinal Ganglion Cell Layer Thickness Is Not Reduced in Patients with Obstructive Sleep Apnea

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