Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients

Background: Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in peripapillary retinal nerve fiber layer (RNFL) thickness in patients with migraine. The aim of this study was to investigate the retinal nerve fiber layer (RNFL) thickness in patients with migraine.Methods: This cross-sectional study was conducted by including thirty patients diagnosed with migraine and thirty normal individuals. Patients were evaluated in groups including migraine with and without aura and controls. Retinal nerve fiber layer (RNFL) thickness was measured using stratus optical coherence tomography (OCT) and then was compared in case and control groups. All data were analyzed using SPSS software version 16.Results: RNFL thickness was significantly thinner in migraine patients compared to the control group. Symmetricity of RNFL showed significantly reduction in patients with migraine compared to standard value (95% vs 68%). Comparison of NRR area between patients and standard value showed significantly reduced values (P=0.0001). Mean value of optic disc area showed significantly reduced value compared to standard value about 2.35 m2 (P=0.0001).Conclusions: This study suggests that migraine leads to a reduction in the peripapillary RNFL thickness and to thinning in choroidal structures. These findings can be explained by a chronic ischemic insult related to migraine pathogenic mechanisms.

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“…9,10 It is noteworthy that RNFL is used as a simple test to evaluate headache progression over time.…”

Section: Discussionmentioning

confidence: 99%

Assessment of retinal nerve fiber layer thickness in migraine patients measured with optical coherence tomography

Khosravi

Shahraki²,

Moghaddam

2018

Int J Adv Med

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“…It has been shown that RNFL thinning occurs at different quadrants, and there are also studies regarding the relation between migraine and retrobulbar blood flow alterations. [15][16][17][18][19][20][21] According to Kara et al, 30 the retrobulbar circulation and flow haemodynamics in the left vertebral artery may be altered in both headache and headache-free periods in migraineurs without aura. Glenn et al 31 reported a case of complicated migraine due to bilateral retinal infarction.…”

Section: Discussionmentioning

confidence: 99%

“…2,[7][8][9][10][11][12][13][14] Also, there are studies supporting the ischaemic theory by focusing on the retinal nerve fibre layer (RNFL) thickness detected by optical coherence tomography (OCT) on migraine patients and studies demonstrating that the retina and cerebral structure of migraine patients are affected. [15][16][17][18][19][20][21] In the present study, we used OCT to determine whether RNFL thickness is related to the presence of cerebral WML in migraine patients. Thus, we aimed to evaluate an anatomical relationship of RNFL thickness to MRI findings in migraine patients.…”

Section: Introductionmentioning

confidence: 99%

Retinal Nerve Fibre Layer Thickness of Migraine Patients with or without White Matter Lesions

Şimşek

2016

Neuro-Ophthalmology

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The aim of this study was to determine whether retinal nerve fibre layer (RNFL) thickness is correlated with cerebral white matter lesions (WML) in migraine patients. Forty migraine and 40 healthy subjects were included in this study. The difference in RNFL thickness between the control and a migraine group with WML and a migraine group without WML were investigated using analysis of variance (ANOVA). A Tukey post hoc test was conducted to determine from which group the difference originated. Lower RNFL thicknesses were observed in the migraine patient group where WML was detected using magnetic resonance imaging (MRI), compared with the control group and with the migraine group with no WML. Statistically significant difference was found between the three groups in terms of RNFL thickness. Although there was a statistically significant difference between the control and the migraine group with WML detected with MRI, no statistically significant difference was found in terms of RNFL thickness between the control and the migraine group with no WML related to Tukey post hoc test. Moreover, there was a statistically significant difference between migraine patients with WML and patients without WML in terms of retinal nerve fibre layer thickness. The results indicate that reduction in RNFL detected via optical coherence tomography may be related to cerebral WML in migraine patients. Further studies by neurologists and ophthalmologists are necessary to determine the clinical relevance of the relation between RNFL and cerebral WML. ARTICLE HISTORY

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“…Today, modern technological OCT devices are employed for the in vivo quantitative measurement of the peripapillary RNFL, GCL, and choroid layer in various neuro-ophthalmological diseases. The reduction in RNFL thickness reflects the loss of ganglion cells and axons in migraine patients (4)(5)(6) . We expected the retina and optic nerve to be affected in recurrent migraine attacks with aura due to hypoperfusion.…”

Section: Introductionmentioning

confidence: 99%

“…Cerebral blood flow in the occipital hemisphere has been shown to diminish during migraine attacks, especially in migraine with aura. Hypoperfusion has been reported to affect the retina and the optic nerve, as well as result in ganglion cell loss (4) . The retinal nerve fiber layer (RNFL) contains the axons of the retinal ganglion cells.…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine

Colak¹,

Kantarcı²,

Tatar³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Espessuras da camada de fibras nervosas retinianas, complexo de células ganglionares e coroide na enxaqueca ABSTRACTPurpose: To evaluate the thicknesses of the peripapillary retinal nerve fiber layer (RNFL), ganglion cell complex (GCL), and choroid layer using spectral domain optical coherence tomography (SD-OCT) for investigating the effects of vascular changes on the eye and optic nerve in patients who have migraine with aura. Methods: Forty-five patients who had migraine with aura (migraine group) and 45 healthy individuals (control group) were enrolled in the study. Age, gender, duration after migraine diagnosis, intraocular pressure, and axial length measurements were recorded in each case. RNFL, GCL, and choroid layer thicknesses were measured using SD-OCT in all participants. Results: The mean age was 36.1 ± 6.7 (20-45) years in the migraine group and 35.7 ± 8.6 (19-45) years in the control group. There was no significant difference in the RNFL thicknesses of the temporal and nasal quadrants (p>0.05). The RNFL thicknesses of the superior and inferior quadrants were significantly lower in the migraine group compared with those in the control group (p=0.001, p<0.01, respectively). Measurements for the superior and inferior GCL were not significantly different between the groups (p>0.05). Subfoveal, temporal, and nasal choroidal thickness measurements at 500 µm, 1000 µm, and 1500 µm were significantly lower in the migraine group than in the control group (p=0.001; p<0.01, respectively). Conclusions:Compared with the controls, the RNFL and choroid layer were determined to be thinner in patients who had chronic migraine with aura. de 36,1 ± 6,7 (20-45) anos no grupo enxaqueca e 35,7 ± 8,6 (19-45) Keywords

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Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients

Abstract: The RNFL in the temporal quadrant was found to be thinner in migraine patients. In addition, we found a strong correlation between migraine severity and the RNFL average thickness parameters.

Cited by 93 publications

References 34 publications

Assessment of retinal nerve fiber layer thickness in migraine patients measured with optical coherence tomography

Assessment of retinal nerve fiber layer thickness in migraine patients measured with optical coherence tomography

Retinal Nerve Fibre Layer Thickness of Migraine Patients with or without White Matter Lesions

Retinal nerve fiber layer, ganglion cell complex, and choroidal thicknesses in migraine

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