Retinal nerve fibre layer thickness measurements in childhood glaucoma: the role of scanning laser polarimetry and optical coherence tomography

Lever, M. J.; Halfwassen, Christian; Unterlauft, Jan Darius; Bechrakis, Nikolaos E.; Manthey, Anke; Böhm, Michael

doi:10.1007/s00417-021-05276-z

Cited by 4 publications

(2 citation statements)

References 37 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 7 8 9 ] Lever et al . [ 26 ] reported that parapapillary RNFL thickness was decreased in the superior, nasal, and inferior quadrants of childhood glaucoma patients compared to healthy controls. Srinivasan et al .…”

Section: Discussionmentioning

confidence: 99%

Evaluation of visual field changes with retinal nerve fiber layer thickness in primary congenital glaucoma

Naik

Sihota

Mahalingam

et al. 2022

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

Purpose: To evaluate visual field changes in primary congenital glaucoma (PCG) with retinal nerve fiber layer thickness on optical coherence tomography. Methods: In this cross-sectional, observational study, consecutive PCG children who underwent combined trabeculotomy with trabeculectomy and on regular follow-up were enrolled. All patients were aged over four years and co-operative for RNFL OCT and visual field examination. Perimetry was done on Humphrey visual field (HVF) analyzer using 30-2 and 10-2 SITA standard algorithms as appropriate. If a reliable automated perimetry was not feasible, kinetic perimetry was done. The following were noted at baseline and every follow-up: age, sex, visual acuity, intraocular pressure (IOP), cup–disc ratio (CDR), corneal diameters, refraction, any topical antiglaucoma medications, surgeries underwent, age at surgery and duration between surgery and final examination. Results: Forty-eight eyes of 34 children operated for PCG and 19 eyes of 17 controls were analyzed. A statistically significant thinner average RNFL thickness of 87.2 ± 28 μm was noted in PCG eyes as compared to controls with 100.6 ± 7.2 μm ( P = 0.04). The mean cup–disc area ratio on OCT in PCG eyes was 0.43 ± 0.2 (0.02–0.93) and in control eyes was 0.23 ± 0.07 (0.1–0.4) ( P < 0.001). On RNFL OCT, there was significant focal RNFL loss in temporal superior ( P = 0.003), nasal inferior ( P = 0.037) and temporal inferior ( P < 0.001) quadrants compared to controls. Among PCG eyes, 20/48 eyes (41.7%), had definitive, reproducible glaucomatous VF defects. Mean baseline IOP in PCG eyes with VF defect was 28.7 ± 5.7 mmHg and in eyes with normal VF was 24.6 ± 5.9 mmHg ( P = 0.03). On univariate regression analysis, higher baseline IOP was significantly associated with both RNFL loss (odds ratio (OR): −2.17) and VF defects (OR: 3.35). Fluctuation in follow-up IOP (OR: 3.33) was also significantly associated with the presence of VF defects. On multivariable regression analysis maximum, IOP was significantly associated with RNFL loss and VF defects. Conclusion: Peripapillary RNFL thickness could be used to identify PCG eyes having visual field loss and possibly poor visual function from PCG eyes without visual field defects. Baseline and follow-up IOP, significantly correlated with RNFL thickness in PCG eyes.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of visual field changes with retinal nerve fiber layer thickness in primary congenital glaucoma

Naik

Sihota

Mahalingam

et al. 2022

Indian Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Литературные данные об изменениях параметров ОКТ при ПВГ и возможности их использования для диагностики и оценки прогрессирования ГОН противоречивы и основаны на небольшом клиническом материале [7][8][9][10][11].…”

unclassified

Optical coherence tomography in the diagnosis of glaucomatous optical neuropathy in children with primary congenital glaucoma

Katargina,

Arestova,

Demchenko

et al. 2023

Rossijskij oftalʹmologičeskij žurnal

View full text Add to dashboard Cite

Purpose: to analyze morphometric, clinical and functional manifestations of glaucomatous optical neuropathy in congenital childhood glaucoma (CG).Material and methods. We examined 103 children (163 eyes) with (CG), including 54 children (86 eyes) with primary congenital glaucoma (PCG) aged 1 month to 17 years. In addition to the regular ophthalmological examination, we performed optical coherence tomography of the optic nerve head (ONH), flash visual evoked potentials, total and rhythmic electroretinogram, oscillatory potentials (OP), echobiometry of the eye axial length.Results. The thickness of the retinal nerve fiber layer peripapillary (pRNFL) ranged from 32 to 120 μm, averaging 71.67 ± 18.2 μm. The thinning was detected in 83.0% of cases, primarily in the temporal sectors (90.6%). As the condition progressed, a tendency to progressive thinning of the RNFL was detected. The minimum rim width (BMO-MRW) ranged from 87 to 336 μm and was reduced in most children (14 out of 16, 87.5%). A strong inverse correlation of the neuroretinal rim with the depth (r = -0.69) and the width (r = -0.93) of the excavation was detected. Also, a strong direct correlation was established between the minimum neuroretinal rim width reduction and the thickness of the BMO-MRW and pRNFL (r = 0.79), as well as the upper and lower temporal sectors (r = 0.81 and r = 0.88, respectively). The thickness of the ganglion cell (GC) layer varied from 8 to 23 μm and averaged 14.64 ± 4.89 μm, with a reduction recorded in most cases (64.7%). All patients showed a decrease in oscillatory potentials (OP) by 40% or more (6.31 ± 2.33) as compared to the control group (20.24 ± 6.28). Thinning of the RNFL was registered in these eyes in 90.6% of cases averagely (p < 0.05) and in the upper and the lower temporal sectors (p < 0.05).Conclusion. RNFL thickness, the minimal width of the BMO-MRW and the OP are the most sensitive criteria to assess the degree of glaucomatous optic neuropathy in children with PСG. The study of the GC layer thickness can serve as an additional diagnostic criterion of assessing the state of the ONH.

show abstract

Impact of social determinants of health on follow-up adherence, testing completion, and outcomes among pediatric glaucoma patients at a tertiary care center

Heckenlaible,

Attzs,

Kraus

2024

Journal of American Association for Pediatric Ophthalmology and

View full text Add to dashboard Cite

Retinal nerve fibre layer thickness measurements in childhood glaucoma: the role of scanning laser polarimetry and optical coherence tomography

Cited by 4 publications

References 37 publications

Evaluation of visual field changes with retinal nerve fiber layer thickness in primary congenital glaucoma

Evaluation of visual field changes with retinal nerve fiber layer thickness in primary congenital glaucoma

Optical coherence tomography in the diagnosis of glaucomatous optical neuropathy in children with primary congenital glaucoma

Impact of social determinants of health on follow-up adherence, testing completion, and outcomes among pediatric glaucoma patients at a tertiary care center

Contact Info

Product

Resources

About