Retinal sensitivity measurement over drusen using scanning laser ophthalmoscope microperimetry

Y, Takamine; Shiraki, Kunihiko; Moriwaki, Mitsuyasu; Yasunari, Takaharu; Miki, Tokuhiko

doi:10.1007/s004170050079

Cited by 25 publications

(16 citation statements)

References 11 publications

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“…[8][9][10][11] In contrast, other studies reported no difference in sensitivity between drusen and nondrusen areas.…”

Section: Resultsmentioning

confidence: 88%

“…[3][4][5][6][7] Functional loss due to AMD was previously demonstrated by findings of reduced visual field sensitivity in retinal locations with drusen compared with nondrusen locations, using scanning laser ophthalmoscope (SLO) perimetry and microperimetry. [8][9][10][11] In contrast, other studies reported no difference in sensitivity between drusen and nondrusen areas. 12 Optical coherence tomography (OCT) is a noninvasive imaging technique that provides cross-sectional images of retinal layer structure, useful for visualization of pathology.…”

Section: Resultsmentioning

confidence: 88%

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4379 The Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

Acton¹

2012

SciVee

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PURPOSE. To quantify and compare the structural and functional changes in subjects with early age-related macular degeneration (AMD), using spectral-domain optical coherence tomography (SD-OCT) and microperimetry.METHODS. Twenty-one eyes of 21 subjects with early AMD were examined. MP-1 10-2 visual fields (VFs) and SD-OCT line and detail volume scans were acquired. The thicknesses of the outer segment (OS; distance between inner segment ellipsoid band and upper retinal pigment epithelium [RPE] border) and RPE layers and elevation of the RPE from Bruch's membrane were measured using a computer-aided manual segmentation technique. Thickness values were compared with those for 15 controls, and values at locations with VF total deviation defects were compared with values at nondefect locations at equivalent eccentricities. RESULTS.Sixteen of 21 eyes with AMD had VF defects. Compared with controls, line scans showed significant thinning of the OS layer (P ¼ 0.006) and thickening and elevation of the RPE (P ¼ 0.037, P ¼ 0.002). The OS layer was significantly thinner in locations with VF defects compared with locations without defects (P ¼ 0.003). There was a negligible difference between the retinal layer thickness values of the 5 eyes without VF defects and the values of normal controls.CONCLUSIONS. In early AMD, when VF defects were present, there was significant thinning of the OS layer and thickening and elevation of the RPE. OS layer thinning was significantly associated with decreased visual sensitivity, consistent with known photoreceptor loss in early AMD. For AMD subjects without VF defects, thickness values were normal. The results highlight the clinical utility of both SD-OCT retinal layer quantification and VF testing in early AMD. (Invest Ophthalmol Vis Sci. 2012;53:7618-7624) DOI:10.1167/iovs.12-10361 A ge-related macular degeneration (AMD) is the third leading cause of blindness worldwide, accounting for 8.7% of blindness in the global population.1 Due to the increase in the average lifespan of the elderly population, it is expected that 17.8 million individuals in the United States will be affected by 2050.2 In view of the relevance of AMD as a public health issue, it is important to understand the changes that occur in the early stages of disease, which may lead to improved future intervention strategies.There has been recent interest in the use of fundus perimetry, also known as microperimetry, as an outcome measure in clinical trials of macular disease.3-7 Functional loss due to AMD was previously demonstrated by findings of reduced visual field sensitivity in retinal locations with drusen compared with nondrusen locations, using scanning laser ophthalmoscope (SLO) perimetry and microperimetry. [8][9][10][11] In contrast, other studies reported no difference in sensitivity between drusen and nondrusen areas. 12Optical coherence tomography (OCT) is a noninvasive imaging technique that provides cross-sectional images of retinal layer structure, useful for visualization of pathology. Spectral-domain O...

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“…[8][9][10][11] In contrast, other studies reported no difference in sensitivity between drusen and nondrusen areas.…”

Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 88%

4379 The Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

Acton¹

2012

SciVee

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“…Entretanto, a sensibilidade macular parece ser a mesma em áreas com e sem drusas (17) . Não foi observada diferença de sensibilidade sobre drusas moles, entretanto encontrou-se diferença de sensibilidade retiniana na área de drusas grandes utilizando o ORL (21) . Tais autores definiram drusas moles como aquelas com margens mal definidas e drusas grandes como aquelas com margens bem definidas, ambas acima de 125 µm.…”

Section: Discussionunclassified

“…Esses autores provavelmente utilizaram áreas de atrofia nesse grupo de drusas grandes, pelas características anatômicas descritas e pelo resultado de escotomas absolutos (zero dB), encontrados em algumas áreas, demostrando atrofia retiniana nesse local. Estas importantes diferenças na metodologia e na interpretação dos resultados utilizados por outros autores (21) podem justificar a diferença de seus resultados em relação aos encontrados neste estudo. Há também relatos de diminuição da sensibilidade em olhos com drusas, porém esse grupo, reconhecendo a limitação do método de perimetria utilizado (Humphrey 10-2), não sugeriu a correlação direta das drusas com a diminuição de sensibilidade, preferindo atribuir tal diminuição a um processo difuso que acomete EPR e retina sensorial.…”

Section: Discussionunclassified

Avaliação da perimetria macular em pacientes com degeneração macular relacionada à idade por meio do oftalmoscópio de rastreamento a laser

Moraes¹,

Elsner²,

Kunze³

et al. 2007

Arq. Bras. Oftalmol.

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“…No change was noted over areas of soft drusen, nor was any correlation found between drusen size and severity of sensitivity loss. 109 Vujosevic and colleagues used this device to demonstrate a decrease in retinal sensitivity in patients with increased FAF signal in the junctional zone surrounding GA. 110 This suggested that LF accumulation in RPE cells surrounding areas of GA resulted in a functional deficit. 71 This supports a previously mentioned observation that the accumulation of LF in the junctional zone precedes the expansion of GA. 65 With the introduction of the MP-1 (Nidek Technologies, Gamagori, Japan), MP was automated and designed to test identical points on the retina during baseline and follow-up testing.…”

Section: Microperimetrymentioning

confidence: 99%

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

Scripsema¹,

Rosen²

2012

US Ophthalmic Review

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Recent advances in retinal imaging have improved the evaluation and prognostication of age-related macular degeneration. The development and modification of the scanning laser ophthalmoscope (SLO) has played a pivotal role in our understanding of the disease. SLO has led to improved methods of visualizing characteristics of the disease, such as drusen and alterations in autofluorescence, and also provided a platform for the quantification of structural and functional changes occurring as a result of the disease process. This article provides a review of the current literature on the impact and clinical utility of SLO devices for infrared viewing, fundus autofluorescence, microperimetry, and as integraded multimodal imaging systems such as optical coherence tomography and SLO.

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Retinal sensitivity measurement over drusen using scanning laser ophthalmoscope microperimetry

Abstract: Large drusen may influence retinal sensitivity and function.

Cited by 25 publications

References 11 publications

4379 The Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

4379 The Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration

Avaliação da perimetria macular em pacientes com degeneração macular relacionada à idade por meio do oftalmoscópio de rastreamento a laser

Scanning Laser Ophthalmoscope in the Management of Age-related Macular Degeneration

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