Retinal Thickness Alterations in Patients with Migraine

Yurtoğulları, Şükran; Timur, İnci Elif Erbahçeci; Eyidoğan, Demet

doi:10.4274/tnd.2020.06791

Cited by 3 publications

(8 citation statements)

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“…On contrary, Reggio et al mentioned that more frequent migrainous attacks were associated with thinning of the RNFL [6]. Another author reported central macular thinning in migraine patient with aura who had frequent attacks [25].…”

Section: Discussionmentioning

confidence: 95%

“…In addition, Yurtoğullari and colleagues found that the thickness of temporal, inferotemporal pRNFL quadrants of the positive aura group, and both of the supero and inferotemporal pRNFL thickness of the negative aura group was thinner than the control group [25]. Similarly, Aksoy and his colleagues reported a remarkable difference in the thickness of temporal pRNFL quadrant compared to healthy control [26].…”

Section: Discussionmentioning

confidence: 99%

“…Although OCT-based measurements of RNFL thickness showed different results, most of the data revealed that there is affection of multiple quadrants based on heterogeneous pathophysiologic mechanism of migraine attributed mainly to the neurovascular theory with the activation of trigeminovascular system release of inflammatory and vasoactive neuropeptides from peripheral nerve endings extracranially at the eye causing inflammatory compromise and vasospasm of ophthalmic, retinal and posterior ciliary arteries with hypoperfusion and axon loss resulting in decreased RNFL diameter [24,25].…”

Section: Discussionmentioning

confidence: 99%

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The potential impact of migraine headache on retinal nerve fiber layer thickness

Mohamed

Hussein

Thabet

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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Background Migraine is a common, chronic, multifactorial neurovascular disorder. It may result in hypoperfusion of other areas other than the brain, as the eye. It may lead to change of the retinal nerve fiber layers (RNFL) thickness and axonal loss even up to severe damage of the eye structures, including the retina with frequent headache attacks. This study aimed to quantify the thickness of RNFL which gives a good idea about the condition of axons and loss of ganglion cells in migraine patients. Also, to detect if there is any correlation between these measurements and clinical characteristics of migraine. Results The RNFL thickness was significantly thinner in patients with migraine compared to healthy controls in all quadrants of retina in both sides (p value < 0.05). However, there was no significant difference in RNFL thickness in migraine patients with aura compared to patients without aura in all retinal quadrants in both sides (p value > 0.05). The headache intensity was negatively correlated with RNFL thickness in the inferior (r = − 0.342, P = 0.031) and nasal (r = − 0.349, P = 0.027) quadrants on LT side, also there was a significant positive correlation between RNFL thickness and both of nausea and tolerability in the RT superior quadrant (r = 0.467, P = 0.002); (r = 0.322, P = 0.043), respectively, but there was no significant correlation found between the RNFL thickness and disability, attacks duration, disease duration and frequency in all retinal quadrants on both sides (P > 0.05). Conclusion The main conclusion of our work was that RNFL thickness was significantly affected in migraine patients in comparison to healthy controls, but there were no significant impact of the migraine characteristics including aura, severity, frequency, or duration of headache attacks on RNFL thickness.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The potential impact of migraine headache on retinal nerve fiber layer thickness

Mohamed

Hussein

Thabet

et al. 2022

Egypt J Neurol Psychiatry Neurosurg

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“…Nineteen studies showed ganglion cell complex thinning in migraineurs (Güler et al, 2020). Compared to controls, both aura and non-aura migraineurs had thinner GCL (Ekinci et al, 2014;Reggio et al, 2017;Abdellatif and Fouad, 2018;Altunisik and Oren, 2021;Yurtoğulları et al, 2021), where chronicity and severity yielded greater GCL reduction (Abdellatif and Fouad, 2018). The presence of WMH did not influence this effect (Altunisik and Oren, 2021).…”

Section: Ganglion Cell Layer (Gcl)mentioning

confidence: 98%

“…Different peripapillary areas of the left and right eyes may have RNFL thinning in migraineurs compared to controls (Altunisik and Oren, 2021). In some studies, investigators found no differences between aura and non-aura migraineurs (Altunisik and Oren, 2021;Kanar et al, 2021;Yurtoğulları et al, 2021).…”

Section: Optic Nervementioning

confidence: 99%

Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review

Chaliha,

Vaccarezza,

Charng

et al. 2024

Front. Neurosci.

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Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which measures retinal thickness, and optical coherence tomography angiography (OCTA), which measures vessel density. We searched the databases Google Scholar, ProQuest, Scopus, and Web of Science for studies in English using OCT and OCTA in migraineurs, using the search terms “optical coherence tomography,” “OCT,” “optical coherence tomography angiography,” “OCTA” and “migraine.” We found 73 primary studies, 11 reviews, and 8 meta-analyses pertaining to OCT and OCTA findings in migraineurs. They showed that migraineurs had reduced retinal thickness (via OCT), retinal vessel density, and greater foveal avascular zone area (via OCTA) than controls. OCTA changes reflect a perfusion compromise occurring in migraineurs as opposed to in healthy controls. OCT and OCTA deficits were worse in migraine-with-aura and chronic migraine than in migraine-without-aura and episodic migraine. Certain areas of the eye, such as the fovea, may be more vulnerable to these perfusion changes than other parts. Direct comparison between study findings is difficult because of the heterogeneity between the studies in terms of both methodology and analysis. Moreover, as almost all case–control studies were cross-sectional, more longitudinal cohort studies are needed to determine cause and effect between migraine pathophysiology and OCT/OCTA findings. Current evidence suggests both OCT and OCTA may serve as retinal markers for migraineurs, and further research in this field will hopefully enable us to better understand the vascular changes associated with migraine, perhaps also providing a new diagnostic and therapeutic biomarker.

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Clinical Characteristics of Migraine and Their Association With the Retinal Nerve Fiber Layer Thickness

Shukla,

Mishra,

Shukla

et al. 2024

Cureus

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Background: Migraine is characterized by recurrent episodes of unilateral, pulsating headaches. At the cerebral and ocular levels, it is recognized that the vascular narrowing and loss of blood flow are transient; however, the chronic nature of migraine may result in long-term functional and structural changes in these structures. It could result in axonal loss and an alteration in the thickness of the retinal nerve fiber layers (RNFL). This study aimed to measure the RNFL thickness, which provides a useful indication of the state of the axons and the loss of ganglion cells in migraine patients, and to find out if RNFL thickness and the clinical features of migraine are correlated.Materials and methods: Sixty patients with migraine and 60 age-gender-matched controls were recruited. A complete neurological and ophthalmological examination was performed, and spectral-domain optical coherence tomography (SD-OCT) was done to measure RNFL.Results: All quadrants of the retina on both sides showed non-statistically significant differences in RNFL thickness between migraine patients and controls (p-value >0.05). Furthermore, in all retinal quadrants on both sides, there was no statistically significant difference in RNFL thickness between migraine patients with aura and those without aura (p-value >0.05). Significant correlations were found between the duration of migraine disease and the superior RNFL thickness of both eyes, as well as the inferior RNFL in the right eye. There was also a significant correlation between the headache attack duration and RNFL thickness of the superior retina (p<0.05), Conclusion: Our key finding was that when comparing migraine patients to controls, RNFL thickness did not significantly change; however, the duration of migraine disease did significantly affect RNFL thickness.

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Retinal Thickness Alterations in Patients with Migraine

Cited by 3 publications

References 0 publications

The potential impact of migraine headache on retinal nerve fiber layer thickness

The potential impact of migraine headache on retinal nerve fiber layer thickness

Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review

Clinical Characteristics of Migraine and Their Association With the Retinal Nerve Fiber Layer Thickness

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