Retinal Thickness Analysis in Subjects with Different Refractive Conditions

Abstract

Purpose: The aim of the present study is to evaluate a measure of retinal thinning at the posterior pole in eyes with increasing axial myopia. Methods: 129 eyes of 79 healthy persons with different refractive conditions were examined using a commercially available prototype of retinal thickness analyzer. Results: Increasing myopia has been found to be accompanied by bulbus elongation, and calculation of the values obtained with the instrument revealed a significant decrease in retinal thickness at the posterior pole in eyes with increasing axial myopia, i.e. 4.8 μm/spherical equivalent in the foveolar region and 6.6 μm/spherical equivalent in the other areas of the posterior pole. Conclusion: Our data show retinal thinning at the posterior pole in myopic eyes based for the very first time on in vivo measurements. Furthermore, our findings might influence measurement data for other purposes, if the degree of myopia is not taken into account.

Clinical applications and new developments of optical coherence tomography: an evidence‐based review

“…The axial elongation that accompanies myopia has been reported to produce retinal stretching, 100–102 thinning, 103 reduced retinal cell density and enlarged photoreceptor inner segments 104 . OCT has been used in a research setting to investigate the potential anatomical changes secondary to axial elongation that occurs in myopia.…”

Pre‐treatment choroidal thickness is not predictive of susceptibility to form‐deprivation myopia in chickens

“…Myopic human eyes typically exhibit a thinner retina, choroid and sclera than emmetropic or hyperopic eyes 1–5 . Animal studies suggest that the thinning of these posterior segment layers results from mechanical stretching, creep, active matrix remodelling and/or fluid movement out of the relevant layer 6–12 .…”

“…Myopic human eyes typically exhibit a thinner retina, choroid and sclera than emmetropic or hyperopic eyes. [1][2][3][4][5] Animal studies suggest that the thinning of these posterior segment layers results from mechanical stretching, creep, active matrix remodelling and/or fluid movement out of the relevant layer. [6][7][8][9][10][11][12] Interestingly, the choroid not only becomes thinner in eyes developing myopia, it also tends to become thicker in eyes developing hyperopia (for example, in the eye of a juvenile animal raised wearing a plus powered spectacle lens).…”

Instruments in Biotechnology and Medicine

“…For a continuous retinal thickness map an interpolation is necessary, but focal defects in retinal thickness or disc topography could be overlooked [105]. Furthermore, the image is adversely affected by media opacities [135]. A fluorescent dye is injected into a vein in the patients arm.…”