Retinoic acid embryopathy

Mondal, Dodul; Shenoy, Sreekanth R; Mishra, Santisena

doi:10.4103/ijabmr.ijabmr_469_16

Cited by 25 publications

(26 citation statements)

References 5 publications

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“…Retinoic acid (RA) or tretinoin is an oxidative metabolite of vitamin A that exists in two isoforms: cis and trans . A group of birth defects called retinoic acid embryopathy (RAE) result from the oral administration of 13‐ cis ‐RA . Studies have described an RAE consisting of craniofacial, cardiac, thymic, and central nervous system abnormalities .…”

Section: Introductionmentioning

confidence: 99%

The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver

Barandeh

Mahabadi

Azadbakht

et al. 2019

J of Cellular Biochemistry

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Background: Retinoic acid (RA) is a synthetic vitamin derivative. It exerts toxic and teratogenic effects on the development of embryonic organs in dose-and time-dependent manners in mice. Curcumin is a compound obtained from rhizomes of turmeric (Curcuma longa) and has protective effects on teratogenic agents. The current study examined the effects of curcumin on embryos treated with RA. Methods: A total of 24 female NMRI mice (8-week-old pregnant mice) were investigated in the current study. All of them were treated for 10 days during days 15 to 50 of pregnancy. In the first group, the animals were fed with normal diets (control); in the second group, with 60 mg/kg all-trans RA; in the third group, with 10 mg/kg curcumin; and in the fourth group, with RA and curcumin in their diets. The animals were killed by cervical dislocation at the 18th day of pregnancy and embryos were separated from the uteruses. The embryo weight and crown rump (CR) length were measured, and the SPSS software was used to analyze data.Results: There was a significant increase in the lengths of CR and weights of embryos after using curcumin, but RA had no effect on the length of CR and weight of embryos at a dose of 60 mg/kg. Morphometric assay of liver tissue was performed, and data analysis indicated that there were significant differences between groups in terms of morphometric parameters of liver tissue. Therefore, RA increased the cell number and sinusoid diameter and decreased the cell areas in the embryonic liver tissue. However, curcumin decreased these side effects of RA on the embryonic liver tissue. Conclusion:The results indicated that curcumin could decrease the toxic and teratogenic effects of RA in mouse embryos. K E Y W O R D Scurcumin, morphometric, mouse embryo, retinoic acid

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Section: Introductionmentioning

confidence: 99%

The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver

Barandeh

Mahabadi

Azadbakht

et al. 2019

J of Cellular Biochemistry

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“…Isotretinoin, 13-cis-retinoic acid, has been extensively prescribed for the systemic treatment of severe acne (Layton et al, 2006). However, isotretinoin can cause depression and an increased rate of birth defects if taken during pregnancy (Mondal et al, 2017). Thus, the drug is highly regulated by the US Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

The Anti-Inflammatory Activities of Propionibacterium acnes CAMP Factor-Targeted Acne Vaccines

Wang

Hata

Tong

et al. 2018

Journal of Investigative Dermatology

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Inflammatory acne vulgaris afflicts hundreds of millions of people globally. Propionibacterium acnes, an opportunistic skin bacterium, has been linked to the pathogenesis of acne vulgaris. Our results show that a secretory Christie-Atkins-Munch-Petersen (CAMP) factor of P. acnes is up-regulated in anaerobic cultures. Mutation of CAMP factor significantly diminishes P. acnes colonization and inflammation in mice, demonstrating the essential role of CAMP factor in the cytotoxicity of P. acnes. Vaccination of mice with CAMP factor considerably reduced the growth of P. acnes and production of MIP-2, a murine counterpart of human IL-8. Acne lesions were collected from patients to establish an ex vivo acne model for validation of the efficacy of CAMP factor antibodies in the neutralization of the acne inflammatory response. The P. acnes CAMP factor and two proinflammatory cytokines (IL-8 and IL-1β) were expressed at higher levels in acne lesions than those in nonlesional skin. Incubation of ex vivo acne explants with monoclonal antibodies to CAMP factor markedly attenuated the amounts of IL-8 and IL-1β. Our work using an ex vivo acne model shows that P. acnes CAMP factor is an essential source of inflammation in acne vulgaris.

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“…Although topical retinoids (Vitamin A derivatives) have been on the market for about half a century, data regarding their use and/or exposure in pregnancy are limited. Nevertheless, malformations in the central nervous system (holoprosencephaly, (Wals et al, ), the cranium, the face, the heart and the thymus of infants of topical‐retinoid‐exposed pregnant women have been reported in individual case reports (Lammer et al, ; Mondal, S, & Mishra, ). Additionally, as mentioned before, RA has been shown to be critical for NC formation (Williams & Bohnsack, ).…”

Section: Chemical Agentsmentioning

confidence: 99%

“…Vitamin A embryopathy, a condition caused by in utero exposure to Vitamin A, is characterized by small deformed ears, mandibular hypoplasia, cleft palate and cardiac abnormalities. In effect, this disease has been shown to affect NC development (Mondal et al, ; Mulder et al, ). Additionally, treatment with Isotretinoin impaired normal craniofacial morphogenesis (Makori et al, ) and increased NCCs apoptosis via upregulation of the pro‐apoptotic transcription factor p53.…”

Section: Chemical Agentsmentioning

confidence: 99%

The role of teratogens in neural crest development

Cerrizuela

Vega-Lopez

Aybar

2020

Birth Defects Research

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The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate and the epidermis. They give rise to the neurons and glia of the peripheral nervous system, melanocytes, chondrocytes, smooth muscle cells, odontoblasts and neuroendocrine cells, among others. Neurocristopathies are a class of congenital diseases resulting from the abnormal induction, specification, migration, differentiation or death of NC cells (NCCs) during embryonic development and have an important medical and societal impact. In general, congenital defects affect an appreciable percentage of newborns worldwide. Some of these defects are caused by teratogens, which are agents that negatively impact the formation of tissues and organs during development. In this review, we will discuss the teratogens linked to the development of many birth defects, with a strong focus on those that specifically affect the development of the NC, thereby producing neurocristopathies.Although increasing attention is being paid to the effect of teratogens on embryonic development in general, there is a strong need to critically evaluate the specific role of these agents in NC development. Therefore, increased understanding of the role of these factors in NC development will contribute to the planning of strategies aimed at the prevention and treatment of human neurocristopathies, whose etiology was previously not considered.

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Retinoic acid embryopathy

Cited by 25 publications

References 5 publications

The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver

The protective effects of curcumin on cytotoxic and teratogenic activity of retinoic acid in mouse embryonic liver

The Anti-Inflammatory Activities of Propionibacterium acnes CAMP Factor-Targeted Acne Vaccines

The role of teratogens in neural crest development

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