Retinoids in Embryonic Development

Schubert, Michael; Gibert, Yann

doi:10.3390/biom10091278

Cited by 15 publications

(8 citation statements)

References 24 publications

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“…A recent study shows that the p450 related drug metabolism pathways can regulate the replication of plant virus in insect ( 57 ). In vertebrates, retinoids play key roles in the process of embryonic development and tissue regeneration ( 58 , 59 ). Retinoid system is also harbored by invertebrates ( 60 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

et al. 2022

Front. Immunol.

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Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese Sitobion miscanthi population, provisionally named “Sitobion miscanthi densovirus” (SmDV). Taxonomically, SmDV belongs to genus Hemiambidensovirus. In S. miscanthi, SmDV is hosted in diverse cells and can be horizontally transmitted via wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs.

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Section: Discussionmentioning

confidence: 99%

Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

et al. 2022

Front. Immunol.

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“…The effect of vitamin A on ASD still needs to be further clarified. The active metabolite of vitamin A is retinoic acid (RA), which activates retinoic acid receptors (RARs) and/or retinoid X receptors (RXRs) to regulate gene expression in many cells and tissues ( 33 , 34 ). In a mouse model, RA directly decreased inhibitory synaptic strength in the brain, resulting in excitation/inhibition imbalance ( 35 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Peripheral Blood Levels of Vitamin A and Autism Spectrum Disorder in Children: A Meta-Analysis

2021

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Vitamin A is an essential fat-soluble micronutrient that plays important roles in a surprisingly wide variety of biological processes from early growth and development to brain maintenance. Numerous clinical studies have been conducted to explore the relationship between peripheral vitamin A levels and autism spectrum disorder (ASD), but the results of these studies are controversial. Therefore, we assessed the association between peripheral vitamin A levels and ASD in the present meta-analysis. Relevant records were retrieved through the Embase, Web of Knowledge and PubMed databases up to 13 November 2020. Reference lists were also searched and analyzed. Hedges' g with its corresponding 95% confidence interval (CI) was used to assess the association between peripheral vitamin A levels and ASD. A fixed or random effects model was selected according to a heterogeneity test in overall and subgroup analyses. Five records (six studies) with 935 ASD children and 516 healthy children were included in the present study. Significantly decreased peripheral vitamin A concentrations were observed in ASD children compared with healthy children (Hedges' g = −0.600, 95% CI −1.153 to −0.048, P = 0.033). A similar result was also obtained after removing the studies identified by Galbraith plots. In addition, no obvious publication bias was found in the meta-analysis. The findings of our meta-analysis suggested decreased peripheral vitamin A levels in ASD children compared with healthy children. Further investigations into the effects of vitamin A on the development of ASD are warranted.

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“…In tunicates that have not secondarily lost the RAR gene, RAR-dependent RA signaling is implicated in neurogenesis as well as in tissue regeneration and bud development of budding tunicates [ 104 , 105 ]. The cephalochordate amphioxus is characterized by the most vertebrate-like RA signaling system of all invertebrates [ 99 , 106 ]. It has been demonstrated that the amphioxus RAR/RXR heterodimer can be activated by all- trans -RA, that HOX genes are directly regulated by RAR/RXR and that HOX-mediated RA signaling is essential for neurogenesis and axial patterning [ 107 ].…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

“…It has recently been proposed that this repressive activity of RAR within the RAR/RXR heterodimer could be modified by RXR-dependent ligand binding [ 50 , 102 ]. It thus remains elusive how RA controls development and neurogenesis in mollusks [ 50 , 55 , 56 , 99 , 106 ]. Similarly, although the genomes of most ecdysozoans do not encode a RAR gene, there are indications for active roles of RA signaling in ecdysozoans, for example, during nervous system regeneration and in tissue repair of insects [ 108 , 109 ].…”

Section: Retinoic Acid Receptor (Rar)-dependent Signaling Is Requimentioning

confidence: 99%

Nuclear Receptors and Development of Marine Invertebrates

Miglioli

Canesi

Gomes

et al. 2021

Genes

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Nuclear Receptors (NRs) are a superfamily of transcription factors specific to metazoans that have the unique ability to directly translate the message of a signaling molecule into a transcriptional response. In vertebrates, NRs are pivotal players in countless processes of both embryonic and adult physiology, with embryonic development being one of the most dynamic periods of NR activity. Accumulating evidence suggests that NR signaling is also a major regulator of development in marine invertebrates, although ligands and transactivation dynamics are not necessarily conserved with respect to vertebrates. The explosion of genome sequencing projects and the interpretation of the resulting data in a phylogenetic context allowed significant progress toward an understanding of NR superfamily evolution, both in terms of molecular activities and developmental functions. In this context, marine invertebrates have been crucial for characterizing the ancestral states of NR-ligand interactions, further strengthening the importance of these organisms in the field of evolutionary developmental biology.

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Retinoids in Embryonic Development

Abstract: Retinoids constitute a class of compounds chemically related to vitamin A [...]

Cited by 15 publications

References 24 publications

Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

Identification of a Novel Densovirus in Aphid, and Uncovering the Possible Antiviral Process During Its Infection

Association Between Peripheral Blood Levels of Vitamin A and Autism Spectrum Disorder in Children: A Meta-Analysis

Nuclear Receptors and Development of Marine Invertebrates

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