Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases

Zabetian-Targhi, Fateme; Mahmoudi, Mohammad Jafar; Rezaei, Nima; Mahmoudi, Maryam

doi:10.3945/an.115.008292

Cited by 109 publications

(107 citation statements)

References 118 publications

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“…RBP4 is secreted by the liver and the adipose tissue (it is both a hepatokine and an adipokine), and higher blood levels have been linked to insulin resistance, diabetes mellitus, and coronary artery disease in some reports 48, 49, 50, 51. We observed that circulating RBP4 levels were positively associated with LVMI and LAD.…”

Section: Discussionmentioning

confidence: 59%

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Jeinsen

Short

Xanthakis

et al. 2018

JAHA

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BackgroundAdipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity‐associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community‐based sample.Methods and ResultsWe evaluated 3514 Framingham Heart Study participants (mean age 40 years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid–binding protein 4, retinol‐binding protein 4, fetuin‐A, and adiponectin. We used multivariable linear regression, adjusting for known correlates (including weight), to relate adipokine concentrations (independent variables) to the following echocardiographic measures (dependent variables): left ventricular mass index, left atrial diameter in end systole, fractional shortening, and E/e′. In multivariable‐adjusted analysis, left ventricular mass index was inversely related to circulating leptin and fatty acid–binding protein 4 concentrations but positively related to retinol‐binding protein 4 and leptin receptor levels (P≤0.002 for all). Left atrial end‐systolic dimension was inversely related to leptin but positively related to retinol‐binding protein 4 concentrations (P≤0.0001). E/e′ was inversely related to leptin receptor levels (P=0.0002). We observed effect modification by body weight for select associations (leptin receptor and fatty acid–binding protein 4 with left ventricular mass index, and leptin with left atrial diameter in end systole; P<0.05 for interactions). Fractional shortening was not associated with any of the adipokines. No echocardiographic trait was associated with fetuin‐A or adiponectin concentrations.ConclusionsIn our cross‐sectional study of a large, young to middle‐aged, relatively healthy community‐based sample, key indices of subclinical cardiac remodeling were associated with higher or lower circulating concentrations of prohypertrophic and antihypertrophic adipokines in a context‐specific manner. These observations may offer insights into the pathogenesis of the cardiomyopathy of obesity.

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Section: Discussionmentioning

confidence: 59%

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Jeinsen

Short

Xanthakis

et al. 2018

JAHA

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“…Feng et al 21 showed that RBP4 correlated positively with carotid atherosclerosis in patients with type 2 diabetes mellitus and could be used as an early predictor of CVD. Higher circulating RBP4 concentrations were also observed in subjects with high-grade carotid stenosis, infl ammatory dilated cardiomyopathy, coronary artery disease and advanced heart failure as compared with control subjects 9 . Even though RBP4 has been proposed as an emerging cardiometabolic risk factor in adults 10,22 , there are discrepancies regarding some of the possible metabolic roles of RBP4 in children and adolescents [23][24][25][26] .…”

Section: Discussionmentioning

confidence: 94%

“…Moreover, RBP4 has been recently proposed as an emerging risk factor of atherosclerotic disease in adults 9,10 . It is well established that insulin resistance and compensatory hyperinsulinemia are the main risk factors of CVD, eventually leading to plaque formation and development of atherosclerosis, through which the prominent role of RBP4 as a modulator of atherosclerosis in hyperinsulinemia may be explained 11 .…”

Section: Introductionmentioning

confidence: 99%

The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls

Klisić

Kavarić

Bjelaković

et al. 2017

acc

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SUMMARY -Retinol-binding protein 4 (RBP4) is an emerging risk factor for atherosclerotic disease in adults. However, to our knowledge, there are no studies examining the relationship between RBP4 and cardiovascular risk in young population. Th erefore, we aimed to estimate this potential relationship in overweight/obese adolescent girls. Seventy overweight/obese adolescent girls, mean age 17.6±1.20 years, were included. Anthropometric and biochemical parameters were measured. Cardiovascular risk score (CVRS) was calculated by adding points for each risk factor (e.g., sex, high-density lipoprotein cholesterol (HDL-c), non-HDL-c, smoking, blood pressure and fasting glycemia). According to the risk status, we divided adolescent girls into low, medium and high risk groups (-2≤ CVRS ≤1, 2≤ CVRS ≤4 and CVRS ≥5, respectively). We found signifi cantly higher RBP4 in the high risk group as compared with low risk group (p<0.001). However, multiple linear regression analysis showed waist circumference (beta=0.257, p=0.031) to be the only independent predictor of higher cardiovascular risk (adjusted R 2 =0.342, p<0.001). In conclusion, RBP4 may be associated with higher cardiovascular risk in overweight/obese adolescent girls, but this association is mediated by abdominal obesity.

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“…Very little RBP originates from adipose tissue. RBP-4 is a novel adipokine and a negative acute phase reactant (5). The high concentration of RBP-4 plays a role in the progression of IR through immunity and inflammatory mechanisms in adipose and vascular tissues.…”

Section: Introductionmentioning

confidence: 99%

The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

Tabak

Şimşek

Erdenen³

et al. 2017

Arch. Endocrinol. Metab.

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Objective: We wanted to investigate whether there is a relationship between circulating irisin, retinol binding protein-4 (RBP-4), adiponectin and proinflammatory mediators implicated in the development of insulin resistance (IR) in metabolic syndrome (MetS). Subjects and methods: In 180 individuals, including controls and patients with MetS, we measured fasting plasma insulin, high sensitivity C-reactive protein (hsCRP), pentraxin-3 (PTX-3), interleukin-33 (IL-33), irisin, RBP-4, and adiponectin using ELISA kits. Results: While fasting plasma hsCRP, PTX-3, IL-33, irisin, RBP-4 concentrations were higher, adiponectin levels were lower in patients with MetS than in controls. A correlation analysis revealed that plasma irisin levels were positively associated with MetS components such as waist circumference and waist-hip ratio, low density lipoprotein (LDL) and markers of systemic inflammation such as PTX-3, hsCRP, uric acid, and RBP-4. Adiponectin levels were negatively associated with waist circumference, waist-hip ratio, PTX-3 and LDL. Conclusions: Although the precise mechanisms are still unclear, irisin, RBP-4, adiponectin and PTX-3 are hallmarks of the MetS, which is related to low-grade inflammation. It is conceivable that irisin and adiponectin might contribute to the development of MetS and may also represent novel MetS components. Future clinical studies are needed to confirm and extend these data. Arch Endocrinol Metab. 2017;61(6):515-23

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Retinol Binding Protein 4 in Relation to Diet, Inflammation, Immunity, and Cardiovascular Diseases

Cited by 109 publications

References 118 publications

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community‐Based Cohort

The Association Between Retinol-Binding Protein 4 and Cardiovascular Risk Score is Mediated by Waist Circumference in Overweight/Obese Adolescent Girls

The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

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