RETRACTED: A Randomized, Double-Blind, Placebo-Controlled Study Assessing the Anti-inflammatory Effects of Ketamine in Cardiac Surgical Patients

Bartoc, Cristian; Frumento, Robert J.; Jalbout, Maya I.; Bennett‐Guerrero, Elliott; Du, Evelyn; Nishanian, Ervant

doi:10.1053/j.jvca.2005.12.005

Cited by 73 publications

(58 citation statements)

References 26 publications

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“…11 17 -20 Even a small dose of ketamine administered during induction of anaesthesia significantly attenuated the increase in IL-6 and CRP in cardiac surgical patients undergoing CPB. 11 Therefore, to assess the anti-inflammatory effects of ketamine in OPCAB, we measured CRP, IL-6, and TNF-a, which are all well-established markers of systemic inflammation. In the current trial, ketamine did not significantly affect the pro-inflammatory mediators' serum concentrations and leucocyte counts.…”

Section: Discussionmentioning

confidence: 99%

“…11 Since antiinflammatory effect of ketamine is dose-related, 26 higher dose of ketamine could have attenuated inflammatory reactions in OPCAB. It should be considered that a larger dose of ketamine can elicit adverse haemodynamic modifications towards an increase in myocardial oxygen consumption, 27 since ketamine produces a dose-related increase in cardiovascular stimulation.…”

Section: Discussionmentioning

confidence: 99%

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Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

Cho¹,

Shim

Choi³

et al. 2009

British Journal of Anaesthesia

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

Cho¹,

Shim

Choi³

et al. 2009

British Journal of Anaesthesia

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“…8,9,22 The inflammation period, which is an important risk factor for organ dysfunction following major surgeries, is known to be among AKI pathogeneses. 2,3 The study was based on these premises and it was observed that 1-3 mgkg À1 ketamine infusion during surgery was not better than remifentanil infusion in terms of kidney functions.…”

Section: Discussionmentioning

confidence: 99%

A comparison of the effects of ketamine and remifentanil on renal functions in coronary artery bypass graft surgery

et al. 2015

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We have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-C levels, and creatinine and/or cystatin-C-based eGFR equations in terms of acute kidney injury in coronary artery bypass graft (CABG) surgery. Using a simple randomization method (coin tossing), patients were divided into the two groups and not-blinded to the anesthetist. Remifentanil-midazolam-propofol or ketamine-midazolam-propofol-based anesthetic regimen was chosen. Different eGFR formulas using creatinine (MDRD, CKD-EPI, Cockrauft Gault); cystatin-C (eGFR1, eGFR2) or a combination of creatinine and cystatin-C (eGFR 3) were used to calculate estimated glomerular filtration rates (eGFRs). Highsensitive troponin T was used to determine if ketamine use in coronary surgery contributed to myocardial cell damage. Thirty-seven patients were included in the study (remifentanil group ¼ 19, ketamine Group ¼ 18). Urea, creatinine, cystatin-C levels were comparable between the groups in all the measurement times and also postoperative day 2 samples showed statistically higher results compared to baseline (p50.001). Effects of ketamine and remifentanil on renal functions were found similar. Creatinine and cystatin-C-based eGFR equations resulted similar in our study. Reversible stage 1 acute kidney injury (AKI) was observed on postoperative day 2 in seven patients from the remifentanil group and six patients from the ketamine group. Hs-troponin T was found to be higher in postoperative day 1 samples; there were no significant difference between the groups. Our results indicated that patients who have normal renal functions undergoing on-pump coronary bypass surgery, effects of ketamine and remifentanil on renal functions in terms of AKI were found to be similar.

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“…Anaesthesia and surgery cause immune system impairment expressed as excessive pro-inflammatory responses leading to exacerbated pain, poor wound healing, psychological stress coupled with complications such as sepsis or acute respiratory distress syndrome (ARDS) [1][2][3][4] . Post-operative pain management remains a challenge even in advanced health systems like the USA, where 50-70% patients experience post-operative pain 5 .…”

Section: Introductionmentioning

confidence: 99%

Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial

Luggya¹,

Roche²,

Ssemogerere³

et al. 2017

Afr H. Sci.

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Background: Surgery and Anesthesia cause an excessive pro-inflammatory response. Mulago Hospital is faced with staff shortage making post-operative pain management difficult.Interleukin-6 (IL-6) drives inflammatory pain, endothelial cell dysfunction and fibrogenesis. Ketamine is cheap and, readily available. We hypothesized that its attenuation of serum IL-6 was a surrogate for clinical benefit. Materials and methods: Institutional Review Board's approval was sought and RCT was registered at clinical trials.gov (identifier number: NCT01339065). Consenting patients were randomized to receive pre-incision intravenous ketamine -0.5mg/kg or 0.9% saline placebo in weighted dosing. Blood samples were collected and laboratory analyzed at baseline, post-operatively in PACU, 24 and 48 hours respectively. Results: We recruited 39 patients of whom 18 were randomized to the ketamine arm and 21 in the placebo arm with follow up at 24 and 48 hours. Serum IL-6 and IL-1β levels were analyzed using ELIZA assay of pre-coated micro wells. Ketamine suppressed serum IL-6 at PACU with reduced increase at 24 hours. There was no reaction in 98% of IL-1β assayed. Conclusion: Low-dose ketamine attenuated early serum IL-6 levels due to surgical response with reduced 24 hour increase, but the difference was not statistically significant and we recommend more studies. Sci. 2017;17(2): 500-507. https://dx.doi. org/10.4314/ahs.v17i2.25

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RETRACTED: A Randomized, Double-Blind, Placebo-Controlled Study Assessing the Anti-inflammatory Effects of Ketamine in Cardiac Surgical Patients

Cited by 73 publications

References 26 publications

Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

Effect of low-dose ketamine on inflammatory response in off-pump coronary artery bypass graft surgery

A comparison of the effects of ketamine and remifentanil on renal functions in coronary artery bypass graft surgery

Effect of low-dose ketamine on post-operative serum IL-6 production among elective surgical patients: a randomized clinical trial

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