RETRACTED ARTICLE: Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study

Khattab, Sherif; Mohsen, Iman Abdel; Foutouh, Ismail Aboul; Ashmawi, H S; Mohsen, Marwa; Wely, Madelon van; Veen, Fulco van der; Youssef, Mohamed Ahmed

doi:10.3109/09513590.2010.540600

Cited by 64 publications

(55 citation statements)

References 26 publications

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“…Of the 25 trials included for this review, there were four randomised controlled trials (RCTs) [10][11][12][13], one clinical trial [14], four retrospective cohort studies [15][16][17][18], and sixteen prospective cohort studies [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34]. These studies were conducted globally with a large number originating from USA.…”

Section: Resultsmentioning

confidence: 99%

“…Four of these showed a statistically significant decrease in PIH with the use of metformin throughout pregnancy compared to PCOS and normal populations [15,20,21,23], while one showed an increase in PIH compared to a normal population [26].…”

Section: Pregnancy Induced Hypertension (Pih)mentioning

confidence: 99%

“…Thirteen studies assessed the relationship between metformin and GDM in women with PCOS, with nine showing that continuing metformin throughout pregnancy reduced GDM [10,15,[20][21][22][23]30,32,33]. However, two showed no change [12,31] and two showed increased risk compared to normal populations [16,26].…”

Section: Gestational Diabetes Mellitus (Gdm)mentioning

confidence: 99%

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Use of metformin during pregnancy for women with polycystic ovary syndrome

Fan¹

2013

OJOG

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Objective: The purpose of this article is to review the literature assessing foetal and maternal pregnancy outcomes in women with PCOS who used metformin during pregnancy. Study Design: A literature search was conducted using MEDLINE, with analysis of 25 studies that recorded neonatal and maternal outcomes in women who used metformin during pregnancy. The outcomes assessed in this review include congenital deformities, miscarriages, preterm labour, gestational diabetes (GDM) and pregnancy induced hypertension (PIH). Results: We found that the use of metformin throughout pregnancy correlated with decreased rates of preterm labour, GDM and PIH. Conflicting evidence exists over whether metformin use during pregnancy reduced miscarriage rates. The use of metformin during pregnancy did not increase teratogenicity risks. Conclusion: The use of metformin throughout pregnancy is associated with decreased rates of preterm labour, GDM, and PIH. However, more randomised controls involving larger numbers of participants are required for more definitive results.

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Section: Resultsmentioning

confidence: 99%

Section: Pregnancy Induced Hypertension (Pih)mentioning

confidence: 99%

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Use of metformin during pregnancy for women with polycystic ovary syndrome

Fan¹

2013

OJOG

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“…In the presence of PCOS and a preexisting state of increased insulin resistance accompanying the syndrome, hyperglycemia seems to be induced more easily. The high pre-conception insulin resistance might have a deleterious additive effect on pancreatic beta cells, which are incapable of coping with the additive physiological insulin resistance of pregnancy (Khattab et al, 2011), thereby leading to an increased incidence of GDM (Toulis et al, 2009). …”

Section: Preexisting Insulin Resistancementioning

confidence: 99%

The Impact of Polycystic Ovarian Syndrome on Gestational Diabetes

Aust¹,

Ott²

2011

Gestational Diabetes

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“…It also reduces insulin resistance and insulin secretion, thus decreasing the secretory demands imposed on pancreatic beta-cells by insulin resistance and pregnancy. 15 Likewise, in the study by De Leo (metformin 1700 mg-3g/day) 7 and Khattab (metformin 1-2g/day), 30 resulted in a reduction in gestational diabetes among those who were treated with metformin than among those normal pregnant controls [(0 versus 13%, p <0.005) and (OR=0.17, 95% CI 0.07,0.37) respectively]. However, given the lack of data from well-designed, prospective clinical trials, metformin is currently not indicated for the prevention of GDM.…”

Section: Introductionmentioning

confidence: 97%

The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

Uyking-Naranjo

Consencino

Mirasol

et al. 2013

JAFES

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Objective.To determine the effect of metformin on maternal and neonatal outcome among pregnant Filipino women with polycystic ovary syndrome (PCOS).Methodology.This is a retrospective cohort study of PCOS women who were on metformin treatment prior to achieving pregnancy. The women were divided into two groups: women who continued metformin during pregnancy and women who discontinued metformin at the time the pregnancy was confirmed. Determination of the effect of metformin on pregnancy outcomes were analyzed using chi-square test. Multivariate regression analysis was used to determine the factors related to spontaneous abortion.Result. A total of 101 women continued metformin during pregnancy while 60 women discontinued metformin. Women who continued metformin had lower rates of first trimester spontaneous abortion compared to those who discontinued metformin (5% versus 36.2%, p<0.001). There was no significant difference in gestational diabetes between those who continued and discontinued metformin during pregnancy (19.0% versus 32.6%, p=0.07). Logistic regression analysis showed that only metformin during pregnancy has a protective effect on abortion (OR=0.168; 95% CI 0.048,0.592; p=0.005). The differences in neonatal outcomes between the two groups did not achieve statistical significance.Conclusion. In Filipino women with PCOS, continuous use of metformin during pregnancy reduces the rate of first trimester spontaneous abortion.

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RETRACTED ARTICLE: Can metformin reduce the incidence of gestational diabetes mellitus in pregnant women with polycystic ovary syndrome? Prospective cohort study

Abstract: Metformin is a promising medication for the prevention or reduction of the incidence of GDM and pre-eclampsia in PCOS women.

Cited by 64 publications

References 26 publications

Use of metformin during pregnancy for women with polycystic ovary syndrome

Use of metformin during pregnancy for women with polycystic ovary syndrome

The Impact of Polycystic Ovarian Syndrome on Gestational Diabetes

The Effect of Metformin on Pregnancy Outcome Among Filipino Women with Polycystic Ovary Syndrome

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