RETRACTED ARTICLE: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice

Wu, Qiming; Shuang, E; Yamamoto, Kazushi; Tsuduki, Tsuyoshi

doi:10.1007/s10522-018-9777-1

Cited by 11 publications

(7 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We previously tested using a high-fat diet that contained a large amount of lard in a similar manner to this study and showed that the high-fat diet promoted aging (17). In this study, the carbohydrate-restricted diet accelerated aging more than the previous high-fat diet results.…”

Section: S69supporting

confidence: 52%

“…We recently used SAMP8 mice to examine the effects of a carbohydrate-restricted diet on the process of aging in mice, particularly skin senescence (17). All animal procedures were performed in accordance with the Animal Experiment Guidelines of Tohoku University, and the animal protocol was approved by the Animal Use Committee at Tohoku University (2017AgA-015) (Mizowaki et al, 2017; Iwagaki et al, 2018).…”

Section: Carbohydrate-restricted Diet Promotes Skin Agingmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Carbohydrate-Restricted Diets on the Skin Aging of Mice

Okouchi

Sakanoi

Tsuduki

2019

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

Low-carbohydrate, high-protein diets, known as carbohydrate-restricted diets, are in contrast to the carbohydrate-centric meals typical of the Japanese diet. Carbohydraterestricted diets were reported to reduce visceral fat, owing to which they have attracted attention and been widely implemented. If, as proposed, carbohydrate-restricted diets are effective in delaying senescence, then Japanese diets have a hidden potential to evolve further. However, long-term carbohydrate restriction in mice was reported to have a negative effect on the cardiovascular system, with shortening of lifespan due to activation of mechanistic target of rapamycin (mTOR). As a result, the safety of long-term adherence to carbohydraterestricted diets remains doubtful. Recently, we conducted a study using senescence-accelerated mouse-prone 8 (SAMP8) mice to examine the effects of a carbohydrate-restricted diet on aging and skin senescence, and to determine the effect of long-term carbohydrate restriction on the aging process in mice. Here, we discuss the safety of long-term carbohydrate restriction based on the findings obtained from animal studies.

show abstract

Section: S69supporting

confidence: 52%

Section: Carbohydrate-restricted Diet Promotes Skin Agingmentioning

confidence: 99%

The Effect of Carbohydrate-Restricted Diets on the Skin Aging of Mice

Okouchi

Sakanoi

Tsuduki

2019

J Nutr Sci Vitaminol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Details of the derivatization procedure and LC-MS/MS analysis of SCFAs were described by Zeng et al [12,26]. Serum GABA was determined using an ELISA kit (ImmuSmol SAS, Pessac, France) as described [12,27,28].…”

Section: Methodsmentioning

confidence: 99%

Simultaneous Intake of Euglena gracilis and Vegetables Exerts Synergistic Anti-Obesity and Anti-Inflammatory Effects by Modulating the Gut Microbiota in Diet-Induced Obese Mice

et al. 2019

Self Cite

View full text Add to dashboard Cite

We determined whether the anti-obesity effect provided by the consumption of Euglena gracilis (Euglena), which is rich in insoluble dietary fiber, could be enhanced by the co-consumption of vegetables with an abundance of soluble dietary fiber. Nine-week-old male C57BL/6J mice were divided into five groups as follows: group 1 received a normal diet, group 2 received a high-fat diet, and groups 3, 4, and 5 received high fat diets containing 0.3% paramylon, 1.0% Euglena, or 1.0% Euglena plus 0.3% vegetables (barley leaf, kale, and ashitaba), respectively. Mice were fed ad libitum until 18 weeks of age. Euglena intake significantly reduced visceral fat accumulation in obese mice, and co-consumption of vegetables enhanced this effect. Consumption of Euglena with vegetables reduced adipocyte area, suppressed the expression of genes related to fatty acid synthesis, upregulated genes related to adipocyte lipolysis, and suppressed serum markers of inflammation. Notably, we also observed an increase in the fraction of short-chain fatty acid-producing beneficial bacteria, a reduction in harmful bacteria that cause inflammation, and an increase in short-chain fatty acid production. Therefore, the co-consumption of vegetables enhanced the anti-obesity and anti-inflammatory effects of Euglena, likely by modulating the gut microbiota composition.

show abstract

“…SAMP8 strain shows neurodegenerative and cognitive deficits associated with Alzheimer’s disease, and abnormality in circadian rhythms along with a shorter lifespan [32–34]. A recent study has reported that SAMP8 mice, when fed with a carbohydrate-restricted diet, showed thinning of skin with an increase in senescence indicators and the mTOR activity [35]. Nevertheless, the existing reports regarding SAMP8 mice remain elusive regarding the age-related changes in the epidermis and its stem cells.…”

Section: Introductionmentioning

confidence: 99%

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis

et al. 2019

View full text Add to dashboard Cite

Delayed wound healing and reduced barrier function with an increased risk of cancer are characteristics of aged skin and one possible mechanism is misregulation or dysfunction of epidermal stem cells during aging. Recent studies have identified heterogeneous stem cell populations within the mouse interfollicular epidermis that are defined by territorial distribution and cell division frequency; however, it is unknown whether the individual stem cell populations undergo distinct aging processes. Here we provide comprehensive characterization of age-related changes in the mouse epidermis within the specific territories of slow-cycling and fast-dividing stem cells using old wild-type, senescence-accelerated mouse prone 1 (SAMP1) and SAMP8 mice. During aging, the epidermis exhibits structural changes such as irregular micro-undulations and overall thinning of the tissue. We also find that, in the old epidermis, proliferation is preferentially decreased in the region where fast-dividing stem cells reside whereas the lineage differentiation marker appears to be more affected in the slow-cycling stem cell region. Furthermore, SAMP8, but not SAMP1, exhibits precocious aging similar to that of aged wild-type mice, suggesting a potential use of this model for aging study of the epidermis and its stem cells. Taken together, our study reveals distinct aging processes governing the two epidermal stem cell populations and suggests a potential mechanism in differential responses of compartmentalized stem cells and their niches to aging.

show abstract

RETRACTED ARTICLE: Carbohydrate-restricted diet promotes skin senescence in senescence-accelerated prone mice

Cited by 11 publications

References 51 publications

The Effect of Carbohydrate-Restricted Diets on the Skin Aging of Mice

The Effect of Carbohydrate-Restricted Diets on the Skin Aging of Mice

Simultaneous Intake of Euglena gracilis and Vegetables Exerts Synergistic Anti-Obesity and Anti-Inflammatory Effects by Modulating the Gut Microbiota in Diet-Induced Obese Mice

Wild-type and SAMP8 mice show age-dependent changes in distinct stem cell compartments of the interfollicular epidermis

Contact Info

Product

Resources

About