RETRACTED ARTICLE: Cerium oxide nanoparticle-loaded polyvinyl alcohol nanogels delivery for wound healing care systems on surgery

Abstract

This study was designed to establish the composition of wound bandages based on Cerium nanoparticle (CeNP)-loaded polyvinyl alcohol (PVA) nanogels. The CeNP nanogel (Ce-nGel) was fabricated by the fructose-mediated reduction of Cerium oxide solutions within the PVA matrix. The influences of different experimental limitations on PVA nanogel formations were examined. The nanogel particle sizes were evaluated by transmission electron microscopy and determined to range from $10 to 50 nm. Additionally, glycerol was added to the Ce-nGels, and the resulting compositions (Ce-nGel-Glu) were coated on cotton fabrics to generate the wound bandaging composite. The cumulative drug release profile of the Cerium from the bandage was found to be $38% of the total loading after two days. Additionally, antibacterial efficacy was developed for Gam positive and negative microorganisms. Moreover, we examined in vivo healing of skin wounds formed in mouse models over 24 days. In contrast to the untreated wounds, rapid healing was perceived in the Ce-nGel-Glu-treated wound with less damage. These findings indicate that Ce-nGel-Glu-based bandaging materials could be a potential candidate for wound healing applications in the future.

Local Drug Delivery Strategies towards Wound Healing

“…Nanofibre scaffolds hold great promise for wound healing. These scaffolds are used in the treatment of diabetic ulcers, skin rejuvenation, wound dressings to encourage healing, and haemostasis [ 147 , 148 ]. Nanofibres keep the wound area moist while it heals because of their capacity to hold more moisture within their structures.…”

Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements

“…The anti-bacterial activities are attributed to the production of ROS, inhibitory enzymes, damaging effects on bacterial DNA, and biofilms breaking ability to inhibit the bacterial growth [ 110 ]. In addition, other materials such as cerium, nitric oxide (NO) nanoparticles, bioactive glass, and carbon-based nanoparticles with intrinsic bioactivity have been utilized for chronic wound management [ 111 ]. However, toxicity that was induced by metal-based nanotherapeutics should be considered beforehand otherwise it’s in vivo applications would be restricted.…”

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

“…These nanogels were loaded with the antibiotic gemifloxacin. The nanogels were electrosprayed to be immobilized on the nanofiber mat, obtaining a hybrid release system in which the drug is encapsulated with the aim of being used as an antibacterial for wound dressing with a constant and controlled release of the drug [ 68 , 69 , 97 ].…”

“…Materials such as polyvinylpyrrolidone are used for their biocompatibility in the electrodynamic method to create nanomaterials. This polymer can be mixed with other biomaterials, for example, PCL, in such a way that nanofibers can be developed for healing tissues, helping to dress wounds and supporting their healing [ 97 , 98 ].…”