RETRACTED ARTICLE: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

Abstract

ObjectiveTo investigate the clinicopathological features of collecting duct carcinoma (CDC) and improve its diagnosis and treatment.MethodsA retrospective analysis was performed with clinical data including follow-up results of five patients with CDC.ResultsA total of 5 cases, including 4 males and 1 female, were included in this analysis with the average age 54 years (range 42 to 65). Patients mainly suffered from lumbar pain, hematuria, abdominal mass and low grade fever. Four patients underwent radical nephrectomy while another received palliative nephrectomy. Lymph node metastasis occurred in 3 cases and renal hilum fat metastasis happened to 2 other cases. Tumors was located in the renal medulla and presented invasive growth. They had a tubulopapillary architecture with the hobnail-shaped cells protruding into the glandular lumen, and were accompanied by interstitial fibrosis and dysplasia of epithelial cells in collecting ducts adjacent to the tumors. One tumor was staged at AJCC II, two at AJCC III and two at AJCC IV. Postoperative interferon immunotherapy was applied in 2 cases. Patients were followed up for 5 to 18 months and the average survival time was 10 months.ConclusionThe CDC exhibits special clinicopathological features, high degree of malignancy and poor prognosis. The diagnosis depends on the histopathological examination. Early detection and early surgical treatment are still the main methods to improve the prognosis of patients with CDC.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3702794279387989

Cystic low-grade collecting duct renal carcinoma with liver compression — A challenging diagnosis and therapy: A case report

“…Current relevant literature is dominated mostly by case reports from small institutional cohort studies (Table 1 )[ 3 , 11 , 17 - 27 ]. The reported survival rate is controversial, being mostly reported as a median survival of 13-22 mo after diagnosis[ 5 , 9 ]. The overall survival rate at 1 year and 3 years, for all stages, is reported to be 69% and 45%, respectively[ 2 , 5 ].…”

“…The reported survival rate is controversial, being mostly reported as a median survival of 13-22 mo after diagnosis[ 5 , 9 ]. The overall survival rate at 1 year and 3 years, for all stages, is reported to be 69% and 45%, respectively[ 2 , 5 ]. A survival benefit of 4-5 mo only, is predicted with chemo-radiotherapy[ 9 ].…”

“…Suspicion of CDC should be confirmed by Hematoxylin-Eosin staining and positivity for UEA I and a large spectrum of keratins, such CKHMW, CK AE1/AE3, CK7, and CK19, associated with positivity for CD15. CDC is negative for CD10, CK20 and villin and might display vimentin and HER-2 expression[ 1 , 3 , 5 , 6 ]. HER-2 positivity, which was not identified in this case, is considered an indicator of poor prognosis[ 10 ].…”

Retraction Note: Collecting duct carcinoma of the kidney: a clinicopathological study of five cases

“…The Publisher and Editor regretfully retract this article [1] because the peer-review process was inappropriately influenced and compromised. As a result, the scientific integrity of the article cannot be guaranteed.…”

Medical image of the week: metastatic collecting duct carcinoma

“…The patient is currently getting outpatient chemotherapy. Collecting duct carcinoma of the kidney is an unusual variant of renal cell carcinoma and accounts for about 1% of all renal cell carcinomas (1). This variant has a poor prognosis and frequently metastasizes to the lung and liver.…”