RETRACTED ARTICLE: Dopamine receptors in human platelets

Rícci, Alberto; Bronzetti, Elena; Mannino, F; Mignini, Fiorenzo; Morosetti, Carolina; Tayebati, Seyed Khosrow; Amenta, Francesco

doi:10.1007/s002100000339

Cited by 41 publications

(26 citation statements)

References 24 publications

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“…[33][34][35][36][37][38] Additionally, there are several blood coagulation pathways involving D 3 receptors systems, including the activation of platelet aggregation and the secretion of the procoagulant von Willebrand factor. 39,40 Hence, D 3 receptors blockade could also predispose the patient to the formation of acute thrombosis in stenotic coronary arteries, contributing to AMI.…”

Section: Discussionmentioning

confidence: 99%

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

et al. 2014

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R ecent evidence suggests that psychiatric patients may be at increased risk for cardiovascular events. Large community studies report that people with mental illnesses have a 2-to 5-fold greater risk of coronary heart disease and a 2-to 3-fold greater risk of cardiac mortality than the general population. [1][2][3] This increased risk might be explained by risk factors commonly noted in these patients, including smoking, obesity, and unhealthy lifestyles. 4-6 Clinical Perspective on p 243The association of risk for acute myocardial infarction (AMI) with antipsychotic treatment remains unclear because earlier analyses have methodological issues (eg, residual confounding and limited statistical power and external validity). 3,[7][8][9][10][11] If the link exists, more attention might be paid to monitoring drug safety, especially because of current increased use of antipsychotics and the widening range of disorders for which they are being indicated. 12This study tapped a large nationwide population-based data set to investigate the association between antipsychotic treatment and risk of AMI in patients with mental disorders. A casecrossover design was used to eliminate known or unknown within-subject time-invariant confounders while examining the acute effects of various antipsychotics on subsequent AMI Background-Antipsychotic medications have been increasingly and more widely prescribed despite continued uncertainty about their association with the incidence of acute myocardial infarction (AMI

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Section: Discussionmentioning

confidence: 99%

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

et al. 2014

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“…Activation of the G␣ s -coupled ␣ 2A adrenoreceptor is reported to inhibit platelet serotonin release (39). The expression of dopamine receptors (D 3 type) in platelets was recently published (40). Preloading of intact Tph1Ϫ/Ϫ platelets was performed with either serotonin or noradrenaline in the absence or presence of spiperone, which blocks 5HT 2A and D 2 -like receptors, BRL 44408, which interferes with ␣ 2A receptors, and GR 103691, antagonizing D 3 receptor-mediated effects at 100 nM each.…”

Section: Down-regulation Of Vmat2 By G␣ Q Does Not Involve Plasmamentioning

confidence: 99%

The Vesicular Monoamine Content Regulates VMAT2 Activity through Gαq in Mouse Platelets

Höltje

Winter

Walther

et al. 2003

Journal of Biological Chemistry

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Variations in the neurotransmitter content of secretory vesicles enable neurons to adapt to network changes. Vesicular content may be modulated by vesicle-associated Go 2 , which down-regulates the activity of the vesicular monoamine transmitter transporters VMAT1 in neuroendocrine cells and VMAT2 in neurons. Blood platelets resemble serotonergic neurons with respect to transmitter storage and release. In streptolysin O-permeabilized platelets, VMAT2 activity is also downregulated by the G protein activator guanosine 5-(␤ i ␥-imido)triphosphate (GMppNp). Using serotonindepleted platelets from peripheral tryptophan hydroxylase knockout (Tph1؊/؊) mice, we show here that the vesicular filling initiates the G protein-mediated downregulation of VMAT2 activity. GMppNp did not influence VMAT2 activity in naive platelets from Tph1؊/؊ mice. GMppNp-mediated inhibition could be reconstituted, however, when preloading Tph1؊/؊ platelets with serotonin or noradrenaline. G␣ q mediates the down-regulation of VMAT2 activity as revealed from uptake studies performed with platelets from G␣ q deletion mutants. Serotonergic, noradrenergic, as well as thromboxane A 2 receptors are not directly involved in the down-regulation of VMAT2 activity. It is concluded that in platelets the vesicle itself regulates transmitter transporter activity via its content and vesicle-associated G␣ q .

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“…Human platelets, a mammalian cell model Human platelets have long been thought to lack D 2 receptors [143], which are the primary target for antipsychotic drugs. However, it has recently been reported that human platelets contain D 2 -like receptors that mediate potentiation of ADP-induced aggregation [149].…”

Section: Human Plateletsmentioning

confidence: 99%

An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes?

et al. 2010

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Patients respond differently to psychotropic drugs, and this is currently a controversial theme among psychiatrists. The effects of 16 psychotropics on cell membrane parameters have been reported. These drugs belong to three major groups used in therapeutic psychiatry: antipsychotics, antidepressants, and anxiolytic/hypnotics. Human platelets, lacking dopamine (D 2 ) receptors (proposed targets of most psychotropics), have been used as a cell model. Here we discuss the effects of these drugs on three metabolic phenomena and also results from Langmuir experiments. Diazepam, in contrast to the remaining drugs, had negligible effects on metabolic phenomena and had no effects in Langmuir experiments. Psychotropic drugs may work through intercalation in membrane phospholipids. It is possible that the fluidity of membranes, rich in essential fatty acids, the content being influenced by diet, could be a contributing factor to the action of psychotropics. This might in turn explain the observed major differences in therapeutic response among patients.

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RETRACTED ARTICLE: Dopamine receptors in human platelets

Cited by 41 publications

References 24 publications

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

Association Between Antipsychotic Use and Risk of Acute Myocardial Infarction

The Vesicular Monoamine Content Regulates VMAT2 Activity through Gαq in Mouse Platelets

An intercalation mechanism as a mode of action exerted by psychotropic drugs: results of altered phospholipid substrate availabilities in membranes?

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