RETRACTED ARTICLE: Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk

Wang, Yang; Men, Xiaojuan; Gu, Yongxue; Wang, Huidong; Xu, Zhicai

doi:10.1186/s12885-021-08571-4

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Its expression decreases in BC cases compared to normal breast tissue (El‐Tanani et al., 2008 ). Several studies and meta‐analyses reported that the polymorphisms of TCF7L2 are associated with BC predisposition (Burwinkel et al., 2006 ; J. Chen et al., 2013 ; Connor et al., 2012 ; Goode et al., 2009 ; Lu et al., 2015 ; Min et al., 2016 ; Naidu et al., 2012 ; F. Wang et al., 2015 ; Y. Wang et al., 2021 ; M. Zhang et al., 2018 ). TCF7L2 can cause effects such as proliferation and invasion in cancer cells by stimulating the transcription of miRNAs through the miR‐21 (Kang, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients

Çıldır,

Özmen,

Kul

et al. 2024

Veterinary Medicine & Sci

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BackgroundDNA repair mechanisms are essential for tumorigenesis and disruption of HR mechanism is an important predisposing factor of human breast cancers (BC). PALB2 is an important part of the HR. There are similarities between canine mammary tumours (CMT) and BCs. As its human counterpart, PALB2 mutations could be a predisposing factor of CMT.ObjectivesIn this study, we aimed to investigate the impacts of PALB2 variants on tumorigenesis and canine mammary tumor (CMT) malignancy.MethodsWe performed Sanger sequencing to detect germline mutations in the WD40 domain of the canine PALB2 gene in CMT patients. We conducted in silico analysis to investigate the variants, and compared the germline PALB2 mutations in humans that cause breast cancer (BC) with the variants detected in dogs with CMT.ResultsWe identified an intronic (c.3096+8C>G) variant, two exonic (p.A1050V and p.R1354R) variants, and a 3′ UTR variant (c.4071T>C). Of these, p.R1354R and c.4071T>C novel variants were identified for the first time in this study. We found that the p.A1050V mutation had a significant effect. However, we could not determine sufficient similarity due to the differences in nucleotide/amino acid sequences between two species. Nonetheless, possible variants of human sequences in the exact location as their dog counterparts are associated with several cancer types, implying that the variants could be crucial for tumorigenesis in dogs. Our results did not show any effect of the variants on tumor malignancy.ConclusionsThe current project is the first study investigating the relationship between the PALB2 gene WD40 domain and CMTs. Our findings will contribute to a better understanding of the pathogenic mechanism of the PALB2 gene in CMTs. In humans, variant positions in canines have been linked to cancer‐related phenotypes such as familial BC, endometrial tumor, and hereditary cancer predisposition syndrome. The results of bioinformatics analyses should be investigated through functional tests or case‐control studies.

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Section: Discussionmentioning

confidence: 99%

Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients

Çıldır,

Özmen,

Kul

et al. 2024

Veterinary Medicine & Sci

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show abstract

“…Recent studies have also confirmed its strong linkage to cancer. For example, the TCF7L2 gene polymorphism is closely associated with the onset of familial breast, colorectal, prostatic, and esophageal cancers [27][28][29][30][31]. However, the correlation of TCF7L2 with GC as well as its effect on the anoikis resistance of GC cells has rarely been reported.…”

Section: Ivyspringmentioning

confidence: 99%

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR

Zhang¹,

Wang²,

Su³

et al. 2022

Int. J. Biol. Sci.

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Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant metastasis is a critical factor in the prognosis of patients with GC. Understanding the mechanism of GC metastasis will help improve patient prognosis. Studies have confirmed that urokinase-type plasminogen activator receptor (PLAUR) promotes GC metastasis; however, its relationship with anoikis resistance and associated mechanisms remains unclear. In this study, we demonstrated that PLAUR promotes the anoikis resistance and metastasis of GC cells and identified transcription Factor 7 Like 2 (TCF7L2) as an important transcriptional regulator of PLAUR. We also revealed that TCF7L2 is highly expressed in GC and promotes the anoikis resistance and metastasis of GC cells. Moreover, we found that TCF7L2 transcription activates PLAUR. Finally, we confirmed that TCF7L2 is an independent risk factor for poor prognosis of patients with GC. Our results show that TCF7L2 and PLAUR are candidate targets for developing therapeutic strategies for GC metastasis.

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Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway

Tang,

Xu,

Wei

et al. 2024

Mol Med

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Background Hepatocellular carcinoma (HCC) is one of the most common malignant tumors of the digestive system, and the exact mechanism of HCC is still unclear. Transcription factor 7 like 2 (TCF7L2) plays a pivotal role in cell proliferation and stemness maintenance. However, the exact mechanism of TCF7L2 in HCC remains unclear. Methods Clinical samples and public databases were used to analyze the expression and prognosis of TCF7L2 in HCC. The function of TCF7L2 in HCC was studied in vitro and in vivo. ChIP and luciferase assays were used to explore the molecular mechanism of TCF7L2. The relationship between TCF7L2 and NEDD9 was verified in HCC clinical samples by tissue microarrays. Results The expression of TCF7L2 was upregulated in HCC, and high expression of TCF7L2 was associated with poor prognosis of HCC patients. Overexpression of TCF7L2 promoted the metastasis of HCC in vitro and in vivo, while Knockdown of TCF7L2 showed the opposite effect. Mechanically, TCF7L2 activated neural precursor cell expressed developmentally downregulated protein 9 (NEDD9) transcription by binding to the -1522/-1509 site of the NEDD9 promoter region, thereby increasing the phosphorylation levels of AKT and mTOR. The combination of TCF7L2 and NEDD9 could distinguish the survival of HCC patients. Conclusions This study demonstrated that TCF7L2 promotes HCC metastasis by activating AKT/mTOR pathway in a NEDD9-dependent manner, suggesting that potential of TCF7L2 and NEDD9 as prognostic markers and therapeutic targets for HCC.

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RETRACTED ARTICLE: Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk

Cited by 3 publications

References 27 publications

Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients

Genetic analysis of PALB2 gene WD40 domain in canine mammary tumour patients

TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR

Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway

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